OR11L1 Olfactory Receptor
| Gene Symbol | OR11L11 (View this gene in GeneCards) |
| Family | 11 |
| Subfamily | L |
| Pseudogene | No |
| CORP pseudogene probability score | 0.21 (functional) |
| Aliases | OR1-50, HsOR1.5.14, ORL3009 |
| External Ids | HGNC: 14998 GeneBank: AB065646, BK004461, NM_001001959 ORDB: ORL3009 |
| Build #39 labels | OR11L1 |
| Chromosomal location | 1:247,840,931-247,841,896 (-) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR10C1 | 50.99% | 304 |
| OR11G2 | 51.16% | 301 |
| OR6B1 | 50.66% | 304 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR11L2 | 78% | 320 |
| Mouse | Or11l3 | 79% | 311 |
| Rat | Or11l3 | 76% | 317 |
| Cow | OR11G2B | 52% | 303 |
| Orang | OR6B1 | 51% | 304 |
| Horse | OR11L4P | 79% | 311 |
| Horse | OR11L1P | 80% | 251 |
| Chimp | OR11G2 | 52% | 302 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | AB529291 |
| GNF Atlas2 | gnf1h10833_at |
Sequence information
| Nucleotide sequence |
ATGGAGCCCCAAAATACCTCCACTGTGACTAACTTTCAGCTGTTAGGATTCCAGAACCTT CTTGAATGGCAGGCCCTGCTCTTTGTCATTTTCCTGCTCATCTACTGCCTGACCATTATA GGGAATGTTGTCATCATCACCGTGGTGAGCCAGGGCCTGCGACTGCACTCCCCTATGTAC ATGTTCCTCCAGCATCTCTCCTTTCTGGAGGTCTGGTACACGTCCACCACTGTGCCCCTT CTCCTAGCCAACCTGCTGTCCTGGGGCCAAGCCATCTCCTTCTCTGCCTGCATGGCACAG CTCTACTTCTTCGTATTCCTCGGCGCCACCGAGTGCTTTCTCCTGGCCTTCATGGCCTAT GACCGTTACCTGGCCATCTGCAGCCCACTCCGCTACCCCTTCCTCATGCATCGTGGGCTC TGTGCCAGGTTGGTGGTGGTCTCCTGGTGCACAGGGGTCAGCACAGGCTTTCTGCCTTCC CTGATGATTTCCAGGTTGGACTTCTGTGGGCGCAATCAGATTAACCATTTCTTCTGCGAC CTCCCGCCACTCATGCAGCTCTCCTGTTCCAGAGTTTATATCACCGAGGTGACCATCTTC ATCCTGTCAATTGCCGTGCTGTGCATTTGTTTTTTTCTGACACTGGGGCCCTATGTTTTC ATTGTGTCCTCCATATTGAGAATCCCTTCCACCTCTGGCCGGAGAAAGACCTTTTCCACA TGTGGCTCCCACCTGGCTGTTGTCACTCTCTACTACGGGACCATGATCTCCATGTATGTG TGTCCCAGTCCCCACCTGTTGCCTGAAATCAACAAGATCATTTCTGTCTTCTACACTGTG GTCACACCACTGCTGAACCCAGTTATCTACAGCTTGAGGAACAAAGACTTCAAAGAAGCT GTTAGAAAGGTCATGAGAAGGAAATGTGGTATTCTATGGAGTACAAGTAAAAGGAAGTTC CTTTAT |
| Conceptual translation |
MEPQNTSTVTNFQLLGFQNLLEWQALLFVIFLLIYCLTIIGNVVIITVVSQGLRLHSPMY MFLQHLSFLEVWYTSTTVPLLLANLLSWGQAISFSACMAQLYFFVFLGATECFLLAFMAY DRYLAICSPLRYPFLMHRGLCARLVVVSWCTGVSTGFLPSLMISRLDFCGRNQINHFFCD LPPLMQLSCSRVYITEVTIFILSIAVLCICFFLTLGPYVFIVSSILRIPSTSGRRKTFST CGSHLAVVTLYYGTMISMYVCPSPHLLPEINKIISVFYTVVTPLLNPVIYSLRNKDFKEA VRKVMRRKCGILWSTSKRKFLY Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 248,004,687 | 248,004,687 | NS | C/G | R/P | rs10888255 (DbSNP) |
| 1 | 248,004,848 | 248,004,848 | NS | C/G | L/F | rs4607924 (DbSNP) |
| 1 | 248,004,775 | 248,004,775 | NS | C/T | A/T | rs10888256 (DbSNP) |
| 1 | 248,004,877 | 248,004,877 | NS | C/T | G/S | rs10888257 (DbSNP) |
| 1 | 248,004,389 | 248,004,389 | SYN | A/G | I/I | rs72761012 (DbSNP) |
| 1 | 248,004,614 | 248,004,614 | SYN | A/G | T/T | rs6667389 (DbSNP) |
| 1 | 248,004,296 | 248,004,296 | SYN | A/G | V/V | rs6681483 (DbSNP) |
| 1 | 248,004,884 | 248,004,884 | SYN | C/T | V/V | rs1339845 (DbSNP) |
| 1 | 248,004,662 | 248,004,662 | SYN | G/A | C/C | rs61748724 (DbSNP) |
| 1 | 247,841,015 | 247,841,015 | NS | G/C | N/K | 1000GP (CEU) |
| 1 | 247,841,546 | 247,841,546 | NS | G/C | F/L | 1000GP (CEU, CHBJPT) |
| 1 | 247,841,385 | 247,841,385 | NS | C/G | R/P | 1000GP (CEU) |
| 1 | 247,841,575 | 247,841,575 | NS | C/T | G/S | 1000GP (CEU) |
| 1 | 247,841,473 | 247,841,473 | NS | C/T | A/T | 1000GP (CEU, CHBJPT) |
| 1 | 247,841,312 | 247,841,312 | SYN | G/A | T/T | 1000GP (CEU, CHBJPT) |
| 1 | 247,840,994 | 247,840,994 | SYN | A/G | V/V | 1000GP (CEU) |
| 1 | 247,841,582 | 247,841,582 | SYN | T/C | V/V | 1000GP (CEU) |
| 1 | 100 | -100 | SYN | A/G | V/V | 1000GP (YRI, YRI, YRI, YRI) |
| 1 | 100 | -100 | NS | C/G | R/P | 1000GP (YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| N294K | R171P | A142T | F117L | G108S | G52D | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | N | P | T | L | S | G | 87.71 | 0.418 |
| 2 | N | R | A | F | G | G | 9.68 | 0.418 |
| 3 | N | R | T | L | G | D | 1.92 | 0.418 |
| 4 | N | R | T | L | S | G | 0.15 | 0.418 |
| 5 | N | R | T | L | S | D | 0.15 | 0.418 |
| 6 | N | P | A | F | G | G | 0.15 | 0.418 |
| 7 | N | P | A | L | S | G | 0.08 | 0.418 |
| 8 | K | P | T | L | S | G | 0.08 | 0.418 |
| 9 | N | R | T | F | G | G | 0.08 | 0.418 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR11L1.aApr07-unspliced | main_exon | 3UTR | chr1 | 247,840,928 | 247,840,931 | - |
| CDS | chr1 | 247,840,931 | 247,841,896 | - | ||