OR1S1 Olfactory Receptor
| Gene Symbol | OR1S11 (View this gene in GeneCards) |
| Family | 1 |
| Subfamily | S |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-232, OST034, HsOR11.12.10, ORL3315 |
| External Ids | HGNC: 8227 GeneBank: AB065493, BK004299, NM_001004458 ORDB: ORL3315 |
| Build #39 labels | OR1S1 |
| Chromosomal location | 11:58,214,784-58,215,719 (+) |
| Cluster | 11@58 |
| Synteny | CLIC#27 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs1966834) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR1S2 | 91.67% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR1S1P | 81% | 312 |
| Mouse | Or1s2 | 81% | 308 |
| Rat | Or1s2 | 78% | 308 |
| Cow | OR1S7 | 75% | 308 |
| Orang | OR1S2 | 93% | 312 |
| Horse | OR1S2 | 83% | 308 |
| Horse | OR1S1B | 81% | 308 |
| Chimp | OR1S2P | 91% | 312 |
Expression evidences
| Source | Accession |
|---|---|
| GNF Atlas2 | gnf1h05452_s_at |
Sequence information
| Nucleotide sequence |
ATGCATCAAGGAAACCAAACCACCATCACTGAATTCATTCTCCTGGGATTTTTCAAGCAG GATGAGCATCAAAACCTCCTCTTTGTGCTTTTCTTGGGTATGTACCTGGTCACTGTGATT GGGAACGGGCTCATCATTGTGGCTATCAGCTTGGATACGTACCTTCATACCCCCATGTAT CTCTTCCTTGCCAATCTATCCTTTGCTGATATTTCCTCCATTTCCAACTCAGTCCCCAAA ATGCTGGTGAATATTCAAACCAAGAGTCAATCCATCTCTTATGAGAGCTGCATCACACAG ATGTACTTTTCTATTGTGTTTGTCGTCATTGACAATTTGCTCTTGGGGACCATGGCCTAT GACCACTTTGTGGCGATCTGCCACCCTCTGAATTATACAATTCTCATGCGGCCCAGGTTC GGCATTTTGCTCACAGTCATCTCATGGTTCCTCAGTAATATTATTGCTCTGACACACACC CTTCTGCTCATTCAATTGCTCTTCTGTAACCACAACACTCTCCCACACTTCTTCTGTGAC TTGGCCCCTCTGCTCAAACTGTCCTGTTCAGATACATTGATCAATGAGCTTGTGTTGTTT ATTGTGGGTTTATCAGTTATCATCTTCCCCTTTACACTCAGCTTCTTTTCCTATGTCTGC ATCATCAGAGCTGTCCTGAGAGTATCTTCCACACAGGGAAAGTGGAAAGCCTTCTCCACT TGTGGCTCTCACCTGACAGTTGTATTACTGTTCTACGGAACCATTGTAGGCGTGTACTTT TTCCCCTCCTCCACTCACCCTGAGGACACTGATAAGATTGGTGCTGTCCTATTCACTGTG GTGACACCCATGATAAACCCCTTCATCTACAGCTTGAGGAATAAGGATATGAAAGGTGCC CTGAGAAAGCTCATCAATAGAAAAATTTCTTCCCTT |
| Conceptual translation |
MHQGNQTTITEFILLGFFKQDEHQNLLFVLFLGMYLVTVIGNGLIIVAISLDTYLHTPMY LFLANLSFADISSISNSVPKMLVNIQTKSQSISYESCITQMYFSIVFVVIDNLLLGTMAY DHFVAICHPLNYTILMRPRFGILLTVISWFLSNIIALTHTLLLIQLLFCNHNTLPHFFCD LAPLLKLSCSDTLINELVLFIVGLSVIIFPFTLSFFSYVCIIRAVLRVSSTQGKWKAFST CGSHLTVVLLFYGTIVGVYFFPSSTHPEDTDKIGAVLFTVVTPMINPFIYSLRNKDMKGA LRKLINRKISSL Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | NS | A/G | Q/R | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | G/T | L/L | 1000GP (YRI) |
| 11 | 57,982,584 | 57,982,584 | NS | T/C | I/T | rs1966835 (DbSNP) |
| 11 | 57,982,620 | 57,982,620 | NS | G/A | R/H | rs1966834 (DbSNP) |
| 11 | 57,982,726 | 57,982,726 | SYN | T/G | L/L | rs1993089 (DbSNP) |
| 11 | 57,982,750 | 57,982,750 | SYN | A/G | Q/Q | rs61746527 (DbSNP) |
| 11 | 57,982,763 | 57,982,763 | NS | G/A | D/N | rs1993088 (DbSNP) |
| 11 | 57,982,832 | 57,982,832 | NS | A/T | M/L | rs2867400 (DbSNP) |
| 11 | 57,982,896 | 57,982,896 | NS | T/G | I/S | rs2903566 (DbSNP) |
| 11 | 57,983,162 | 57,983,162 | NS | A/G | K/E | rs7103026 (DbSNP) |
| 11 | 58,215,112 | 58,215,112 | NS | T/C | I/T | 1000GP (CEU) |
| 11 | 58,215,148 | 58,215,148 | NS | A/G | H/R | 1000GP (CEU, CHBJPT) |
| 11 | 58,215,204 | 58,215,204 | NS | G/A | G/S | 1000GP (CEU) |
| 11 | 58,215,254 | 58,215,254 | SYN | G/T | L/L | 1000GP (CEU) |
| 11 | 58,215,291 | 58,215,291 | NS | A/G | N/D | 1000GP (CEU, CHBJPT) |
| 11 | 58,215,360 | 58,215,360 | NS | T/A | L/M | 1000GP (CEU) |
| 11 | 58,215,424 | 58,215,424 | NS | G/T | S/I | 1000GP (CEU, CHBJPT) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 210 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| Q103R | I123T | H135R | C140Y | G154S | N183D | S227I | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Q | I | H | C | G | N | S | 49.16 | 0.497 |
| 2 | Q | T | R | C | G | D | I | 45.08 | 0.497 |
| 3 | Q | T | R | C | G | N | I | 3.99 | 0.497 |
| 4 | Q | I | H | Y | G | N | S | 0.69 | 0.497 |
| 5 | R | I | H | C | G | N | S | 0.46 | 0.497 |
| 6 | Q | T | H | C | G | N | S | 0.23 | 0.497 |
| 7 | Q | I | H | C | G | N | I | 0.23 | 0.497 |
| 8 | Q | T | R | C | G | D | S | 0.08 | 0.497 |
| 9 | Q | T | R | C | S | D | I | 0.08 | 0.497 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR1S1.aApr07-unspliced | main_exon | 5UTR | chr11 | 58,214,745 | 58,214,784 | + |
| CDS | chr11 | 58,214,784 | 58,215,719 | + | ||
| 3UTR | chr11 | 58,215,719 | 58,215,722 | + | ||