OR2AG1 Olfactory Receptor
| Gene Symbol | OR2AG11 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | AG |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-79, HsOR11.4.2, ORL3281, ORL3387 |
| External Ids | HGNC: 15142 GeneBank: AB065823, AF399618, BK004295, NM_001004489 ORDB: ORL3281, ORL3387 |
| Build #39 labels | OR2AG1, OR2AG3 |
| Chromosomal location | 11:6,785,038-6,785,985 (+) |
| Cluster | 11@7 |
| Synteny | CLIC#24 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs11826041) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2AG2 | 87.03% | 316 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2AG1D | 83% | 309 |
| Dog | OR2AG1C | 81% | 315 |
| Dog | OR2AG2C | 81% | 315 |
| Mouse | Or2ag1 | 83% | 316 |
| Mouse | Or2ag2 | 80% | 316 |
| Mouse | Or2ag2b | 80% | 316 |
| Rat | Or2ag1 | 83% | 316 |
| Cow | OR2AG1E | 83% | 310 |
| Cow | OR2AG2 | 83% | 310 |
| Cow | OR2AG1FP | 83% | 309 |
| Orang | OR2AG2 | 87% | 316 |
| Horse | OR2AG2 | 82% | 314 |
| Chimp | OR2AG2 | 87% | 316 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC151143 |
| GNF Atlas2 | gnf1h10947_at |
Sequence information
| Nucleotide sequence |
ATGGAGCTCTGGAACTTCACCTTGGGAAGTGGCTTCATTTTGGTGGGGATTCTGAATGAC AGTGGGTCTCCTGAACTGCTCTGTGCTACAATTACAATCCTATACTTGTTGGCCCTGATC AGCAATGGCCTACTGCTCCTGGCTATCACCATGGAAGCCCGGCTCCACATGCCCATGTAC CTCCTGCTTGGGCAGCTCTCTCTCATGGACCTCCTGTTCACATCTGTTGTCACTCCCAAG GCCCTTGCGGACTTTCTGCGCAGAGAAAACACCATCTCCTTTGGAGGCTGTGCCCTTCAG ATGTTCCTGGCACTGACAATGGGTGGTGCTGAGGACCTCCTACTGGCCTTCATGGCCTAT GACAGGTATGTGGCCATTTGTCATCCTCTGACATACATGACCCTCATGAGCTCAAGAGCC TGCTGGCTCATGGTGGCCACGTCCTGGATCCTGGCATCCCTAAGTGCCCTAATATATACC GTGTATACCATGCACTATCCCTTCTGCAGGGCCCAGGAGATCAGGCATCTTCTCTGTGAG ATCCCACACTTGCTGAAGGTGGCCTGTGCTGATACCTCCAGATATGAGCTCATGGTATAT GTGATGGGTGTGACCTTCCTGATTCCCTCTCTTGCTGCTATACTGGCCTCCTATACACAA ATTCTACTCACTGTGCTCCATATGCCATCAAATGAGGGGAGGAAGAAAGCCCTTGTCACC TGCTCTTCCCACCTGACTGTGGTTGGGATGTTCTATGGAGCTGCCACATTCATGTATGTC TTGCCCAGTTCCTTCCACAGCACCAGACAAGACAACATCATCTCTGTTTTCTACACAATT GTCACTCCAGCCCTGAATCCACTCATCTACAGCCTGAGGAATAAGGAGGTCATGCGGGCC TTGAGGAGGGTCCTGGGAAAATACATGCTGCCAGCACACTCCACGCTC |
| Conceptual translation |
MELWNFTLGSGFILVGILNDSGSPELLCATITILYLLALISNGLLLLAITMEARLHMPMY LLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGGAEDLLLAFMAY DRYVAICHPLTYMTLMSSRACWLMVATSWILASLSALIYTVYTMHYPFCRAQEIRHLLCE IPHLLKVACADTSRYELMVYVMGVTFLIPSLAAILASYTQILLTVLHMPSNEGRKKALVT CSSHLTVVGMFYGAATFMYVLPSSFHSTRQDNIISVFYTIVTPALNPLIYSLRNKEVMRA LRRVLGKYMLPAHSTL Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 6,806,816 | 6,806,816 | NS | A/C | H/P | rs74057920 (DbSNP) |
| 11 | 6,806,393 | 6,806,393 | NS | A/G | N/S | rs11826041 (DbSNP) |
| 11 | 6,806,671 | 6,806,671 | NS | C/G | L/V | rs74057919 (DbSNP) |
| 11 | 6,806,827 | 6,806,827 | NS | T/G | L/V | rs2659880 (DbSNP) |
| 11 | 6,807,163 | 6,807,163 | SYN | A/C/G | R/R | rs2659879 (DbSNP) |
| 11 | 6,806,610 | 6,806,610 | SYN | A/G | L/L | rs74057918 (DbSNP) |
| 11 | 6,806,496 | 6,806,496 | SYN | C/T | V/V | rs11041022 (DbSNP) |
| 11 | 6,807,216 | 6,807,216 | SYN | C/T | L/L | rs74057921 (DbSNP) |
| 11 | 6,785,596 | 6,785,596 | NS | G/T | V/L | 1000GP (CEU, CHBJPT) |
| 11 | 100 | -100 | NS | A/G | N/S | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | / | L/L | 1000GP (YRI) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| N42S | Q65H | L114P | L135V | C141S | H183P | V187L | I221N | P262T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | N | Q | L | L | C | H | V | I | P | 72.81 | 0.121 |
| 2 | N | Q | L | L | C | H | L | I | P | 20.74 | 0.118 |
| 3 | S | Q | P | L | C | H | V | I | P | 2.15 | 1.000 |
| 4 | N | Q | L | V | C | P | L | I | P | 1.61 | 0.118 |
| 5 | S | Q | P | L | C | H | V | I | T | 1.08 | 1.000 |
| 6 | S | H | P | L | C | H | V | I | P | 0.46 | 1.000 |
| 7 | N | Q | L | L | S | H | V | I | P | 0.46 | 0.121 |
| 8 | S | Q | L | L | C | H | V | I | P | 0.23 | 1.000 |
| 9 | N | Q | L | L | C | H | V | N | P | 0.23 | 0.121 |
| 10 | N | Q | P | L | C | H | L | I | P | 0.15 | 0.266 |
| 11 | N | Q | L | L | C | P | L | I | P | 0.08 | 0.118 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2AG1.aApr07-unspliced | main_exon | CDS | chr11 | 6,785,038 | 6,785,985 | + |
| 3UTR | chr11 | 6,785,985 | 6,785,988 | + | ||