OR2F2 Olfactory Receptor
| Gene Symbol | OR2F21 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | F |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR7-1, OR7-6, WUGSC:H_DJ0669B10.1, HsOR7.6.6, ORL3179 |
| External Ids | HGNC: 8247 GeneBank: BK004214, NM_001004685 ORDB: ORL3179 |
| Build #39 labels | OR2F2 |
| Chromosomal location | 7:143,935,233-143,936,183 (+) |
| Cluster | 7@144 |
| Synteny | CLIC#16 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2F1 | 90.22% | 317 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2F1C | 84% | 317 |
| Dog | OR2F1D | 84% | 317 |
| Dog | OR2F1 | 84% | 317 |
| Mouse | Or2f2 | 85% | 315 |
| Mouse | Or2f1 | 84% | 317 |
| Mouse | Or2f1b | 83% | 317 |
| Rat | Or2f2 | 86% | 315 |
| Cow | OR2F2B | 87% | 317 |
| Cow | OR2F1 | 86% | 316 |
| Orang | OR2F2P | 94% | 317 |
| Horse | OR2F1 | 85% | 317 |
| Horse | OR2F1F | 83% | 317 |
| Horse | OR2F1H | 82% | 317 |
| Horse | OR2F1G | 84% | 285 |
| Chimp | OR2F1 | 91% | 317 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136813 |
| GNF Atlas2 | 217302_at |
Sequence information
| Nucleotide sequence |
ATGGAAATAGATAACCAGACGTGGGTGAGAGAATTTATTCTCCTTGGCTTATCCAGTGAC TGGTGCACTCAGATATCCCTGTTTTCCCTGTTCTTGGTCACATACCTCATGACAGTGCTG GGGAACTGTCTCATTGTCCTTCTGATCAGACTGGACAGCCGACTCCACACTCCCATGTAT TTCTTTCTCACCAACCTCTCCCTTGTCGATGTCTCCTATGCCACAAGCGTAGTCCCCCAG CTGCTGGCACATTTTCTTGCAGAACATAAAGCCATCCCATTCCAGAGCTGTGCAGCCCAG TTATTTTTCTCCCTGGCCTTGGGTGGGATTGAGTTTGTTCTCCTGGCAGTGATGGCCTAT GACCGCCATGTGGCTGTGTCTGACCGCCTGCGATACTCGGCCATCATGCATGGAGGGCTG TGTGCTAGGTTGGCCATCACATCCTGGGTCAGTGGCTCCATCAACTCTCTTGTGCAGACT GCTATCACCTTTCAGCTGCCCATGTGCACTAACAAGTTTATTGATCACATATCCTGTGAA CTCCTAGCTGTGGTCAGGCTGGCTTGTGTGGACACCTCCTCCAATGAGGCTGCCATCATG GTGTCTAGCATTGTTCTTCTGATGACACCTTTCTGCCTGGTTCTGTTGTCCTACATCCGG ATCATCTCCACCATCCTAAAGATCCAGTCCAGAGAAGGAAGAAAGAAAGCCTTCCACACG TGTGCCTCTCACCTCACGGTGGTTGCCCTGTGCTACGGCACAACGATTTTCACTTACATC CAGCCCCACTCTGGTCCCTCAGTCCTTCAAGAGAAGCTGATCTCTGTCTTCTATGCCATT GTTATGCCTCTGCTGAACCCTGTGATTTATAGTCTAAGGAATAAAGAGGTGAAGGGGGCC TGGCATAAACTATTAGAGAAATTCTCTGGGTTAACATCCAAGCTGGGAACT |
| Conceptual translation |
MEIDNQTWVREFILLGLSSDWCTQISLFSLFLVTYLMTVLGNCLIVLLIRLDSRLHTPMY FFLTNLSLVDVSYATSVVPQLLAHFLAEHKAIPFQSCAAQLFFSLALGGIEFVLLAVMAY DRHVAVSDRLRYSAIMHGGLCARLAITSWVSGSINSLVQTAITFQLPMCTNKFIDHISCE LLAVVRLACVDTSSNEAAIMVSSIVLLMTPFCLVLLSYIRIISTILKIQSREGRKKAFHT CASHLTVVALCYGTTIFTYIQPHSGPSVLQEKLISVFYAIVMPLLNPVIYSLRNKEVKGA WHKLLEKFSGLTSKLGT Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 7 | 143,632,577 | 143,632,576 | Ins(1) | -/T | rs34820838 (DbSNP) | |
| 7 | 143,632,833 | 143,632,833 | NS | A/G | T/A | rs13229174 (DbSNP) |
| 7 | 143,632,717 | 143,632,717 | NS | A/G | Q/R | rs61739648 (DbSNP) |
| 7 | 143,632,984 | 143,632,984 | NS | A/G | Q/R | rs61740239 (DbSNP) |
| 7 | 143,632,359 | 143,632,359 | NS | A/T | I/F | rs60344499 (DbSNP) |
| 7 | 143,632,618 | 143,632,618 | NS | C/T | A/V | rs2240359 (DbSNP) |
| 7 | 143,632,983 | 143,632,983 | NS | C/T | R/W | rs61746066 (DbSNP) |
| 7 | 143,633,157 | 143,633,157 | NS | C/T | H/Y | rs13235235 (DbSNP) |
| 7 | 143,633,013 | 143,633,013 | NS | G/T | A/S | rs4286866 (DbSNP) |
| 7 | 143,935,740 | 143,935,740 | NS | A/G | T/A | 1000GP (CEU) |
| 7 | 143,936,064 | 143,936,064 | NS | T/C | Y/H | 1000GP (CEU) |
| 7 | 143,935,891 | 143,935,891 | NS | G/A | R/Q | 1000GP (CEU) |
| 7 | 143,935,890 | 143,935,890 | NS | C/T | R/W | 1000GP (CHBJPT) |
| 7 | 100 | -100 | NS | A/G | T/A | 1000GP (YRI, YRI, YRI, YRI) |
| 7 | 100 | -100 | SYN | G/T | L/L | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 7 | 143,615,165 | 143,744,519 | CopyNumber | Variation_0110 (DGV) |
| 7 | 143,438,261 | 143,655,784 | CopyNumber | Variation_0725 (DGV), Variation_2109 (DGV) |
| 7 | 143,147,775 | 144,368,638 | CopyNumber | Variation_3708 (DGV) |
| 7 | 143,208,034 | 143,736,035 | CopyNumber | Variation_5247 (DGV) |
| 7 | 143,572,286 | 143,866,532 | CopyNumber | Variation_8581 (DGV) |
| 7 | 143,217,296 | 144,074,520 | CopyNumber | Variation_32962 (DGV) |
| 7 | 143,545,719 | 143,874,190 | CopyNumber | Variation_53583 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R131Q | T170A | R220W | R220Q | Y278H | % Freq | CORP | |
|---|---|---|---|---|---|---|---|
| 1 | R | T | R | R | Y | 80.18 | 0.507 |
| 2 | R | A | R | R | H | 10.52 | 0.507 |
| 3 | R | T | R | R | H | 6.07 | 0.507 |
| 4 | R | T | R | Q | Y | 2.46 | 0.507 |
| 5 | Q | T | R | R | Y | 0.23 | 0.507 |
| 6 | R | T | W | R | Y | 0.23 | 0.507 |
| 7 | R | T | W | R | H | 0.23 | 0.507 |
| 8 | Q | T | R | Q | Y | 0.08 | 0.507 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2F2.aApr07-unspliced | main_exon | CDS | chr7 | 143,935,233 | 143,936,183 | + |
| 3UTR | chr7 | 143,936,183 | 143,936,186 | + | ||