OR2H2 Olfactory Receptor
| Gene Symbol | OR2H21 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | H |
| Pseudogene | No |
| CORP pseudogene probability score | 0.17 (functional) |
| Aliases | hs6M1-12, OR6-36, AC006137-A, dJ271M21.2, HsOR6.3.26, ORL4124 |
| External Ids | HGNC: 8253 GeneBank: AB065965, AF211939-AF211942, AF399631, BC069146, BK004225, NM_007160 ORDB: ORL4124 |
| Build #39 labels | OR2H2 |
| Chromosomal location | 6:29,587,945-29,588,880 (+) |
| Cluster | 6@29 |
| Synteny | CLIC#12 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2H1 | 86.86% | 312 |
| OR2H5P | 88.78% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2H9P | 71% | 311 |
| Mouse | Or2h2 | 88% | 307 |
| Rat | Or2h2 | 88% | 307 |
| Cow | OR2H1D | 84% | 312 |
| Cow | OR2H1 | 83% | 306 |
| Orang | OR2H2P | 95% | 312 |
| Horse | OR2H1 | 87% | 306 |
| Horse | OR2H1F | 85% | 306 |
| Chimp | OR2H2P | 82% | 359 |
| Chimp | OR2H1 | 84% | 312 |
| Chimp | OR2H1DP | 84% | 271 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | DB306652 |
| mRNA | BC069146 |
| GNF Atlas2 | 208573_s_at |
| GNF Atlas2 | 217081_at |
Sequence information
| Nucleotide sequence |
ATGGTTAACCAAAGCTCCACACCGGGCTTCCTCCTTCTGGGCTTCTCTGAACACCCAGGG CTGGAAAGGACTCTCTTCGTGGTTGTCTTCACTTCCTACCTCCTAACCCTAGTGGGCAAC ACACTCATCATCCTGCTGTCTGCGCTGGACCCCAAGCTCCACTCTCCAATGTACTTTTTC CTCTCCAACCTCTCCTTCTTGGACCTCTGTTTCACCACGAGTTGTGTTCCCCAAATGCTG GTCAACCTCTGGGGCCCAAAGAAGACCATCAGCTTCCTGGACTGCTCTGTCCAGATCTTC ATCTTCCTGTCCCTGGGGACAACTGAGTGCATCCTCTTGACAGTGATGGCTTTTGATCGC TACGTGGCTGTCTGCCAGCCCCTCCACTATGCCACCATCATCCACCCCCGCCTGTGCTGG CAGCTGGCATCTGTGGCCTGGGTCATTGGGCTAGTGGAGTCAGTGGTCCAGACACCATCC ACCCTGCACCTGCCCTTCTGCCCCGATCGGCAGGTGGATGATTTTGTCTGTGAGGTCCCA GCTCTAATTCGACTCTCCTGTGAAGACACCTCCTACAATGAGATCCAGGTGGCTGTTGCC AGTGTCTTCATCTTGGTTGTGCCTCTCAGCCTCATCCTTGTCTCTTACGGAGCCATTACC TGGGCAGTGCTGAGGATTAACTCTGCAAAAGGGCGGAGGAAAGCTTTTGGGACCTGCTCC TCCCATCTCACTGTGGTCACCCTCTTCTACAGCTCAGTCATTGCTGTCTACCTCCAGCCC AAAAATCCCTATGCCCAAGAGAGGGGCAAGTTCTTTGGTCTCTTCTATGCAGTGGGCACT CCTTCACTTAACCCTCTCATATACACCCTGAGGAACAAGGAGGTAACCAGGGCATTCAGG AGATTGCTGGGGAAGGAAATGGGGCTCACACAAAGC |
| Conceptual translation |
MVNQSSTPGFLLLGFSEHPGLERTLFVVVFTSYLLTLVGNTLIILLSALDPKLHSPMYFF LSNLSFLDLCFTTSCVPQMLVNLWGPKKTISFLDCSVQIFIFLSLGTTECILLTVMAFDR YVAVCQPLHYATIIHPRLCWQLASVAWVIGLVESVVQTPSTLHLPFCPDRQVDDFVCEVP ALIRLSCEDTSYNEIQVAVASVFILVVPLSLILVSYGAITWAVLRINSAKGRRKAFGTCS SHLTVVTLFYSSVIAVYLQPKNPYAQERGKFFGLFYAVGTPSLNPLIYTLRNKEVTRAFR RLLGKEMGLTQS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 6 | 29,555,738 | 29,555,738 | NS | A/C | Y/S | rs61744969 (DbSNP) |
| 6 | 29,555,809 | 29,555,809 | NS | A/C/G/T | L/F/V/I | rs3129034 (DbSNP) |
| 6 | 29,556,416 | 29,556,416 | NS | A/G | Q/R | rs73744761 (DbSNP) |
| 6 | 29,555,833 | 29,555,833 | NS | A/G | M/V | rs11966382 (DbSNP) |
| 6 | 29,556,100 | 29,556,100 | NS | C/T | P/S | rs36211077 (DbSNP) |
| 6 | 29,555,864 | 29,555,864 | NS | T/C | V/A | rs1233387 (DbSNP) |
| 6 | 29,556,345 | 29,556,345 | SYN | C/T | P/P | rs72500875 (DbSNP) |
| 6 | 29,556,225 | 29,556,225 | SYN | C/T | P/P | rs61997184 (DbSNP) |
| 6 | 29,555,778 | 29,555,778 | SYN | G/A | P/P | rs2235698 (DbSNP) |
| 6 | 29,588,032 | 29,588,032 | NS | C/T | L/F | 1000GP (CEU, CHBJPT) |
| 6 | 29,588,001 | 29,588,001 | SYN | A/G | P/P | 1000GP (CEU, CHBJPT) |
| 6 | 29,588,087 | 29,588,087 | NS | C/T | A/V | 1000GP (CEU, CHBJPT) |
| 6 | 29,587,961 | 29,587,961 | NS | C/A | S/Y | 1000GP (CHBJPT) |
| 6 | 29,588,448 | 29,588,448 | SYN | C/T | P/P | 1000GP (CHBJPT) |
| 6 | 100 | -100 | SYN | A/G | P/P | 1000GP (YRI) |
| 6 | 100 | -100 | NS | C/T | L/F | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 6 | 29,469,101 | 29,678,670 | CopyNumber | Variation_3598 (DGV) |
| 6 | 29,527,407 | 29,566,446 | CopyNumber | Variation_36504 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| S6Y | L30F | A48V | E838D | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | S | F | A | E | 46.31 | 0.340 |
| 2 | S | F | V | E | 28.42 | 0.340 |
| 3 | S | L | A | E | 22.35 | 0.340 |
| 4 | Y | F | V | E | 2.84 | 0.340 |
| 5 | S | F | A | D | 0.08 | 0.340 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2H2.aApr07 | exon_5UTR | chr6 | 29,586,041 | 29,586,154 | + | |
| main_exon | 5UTR | chr6 | 29,587,670 | 29,587,945 | + | |
| CDS | chr6 | 29,587,945 | 29,588,880 | + | ||
| 3UTR | chr6 | 29,588,880 | 29,588,968 | + | ||
| OR2H2.bApr07-unspliced | main_exon | 5UTR | chr6 | 29,587,455 | 29,587,945 | + |
| CDS_partial | chr6 | 29,587,945 | 29,588,153 | + | ||