OR4A5 Olfactory Receptor
| Gene Symbol | OR4A51 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.12 (functional) |
| Aliases | OR11-111, HsOR11.10.2, ORL3308 |
| External Ids | HGNC: 15162 GeneBank: BK004378 ORDB: ORL3308 |
| Build #39 labels | OR4A5 |
| Chromosomal location | 11:54,706,884-54,707,828 (-) |
| Cluster | 11@51 |
| Synteny | CLIC#26 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4A42P | 91.5% | 306 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4A39 | 76% | 302 |
| Mouse | Or4a39 | 75% | 305 |
| Rat | Or4a77e | 73% | 306 |
| Cow | OR4A2 | 69% | 303 |
| Orang | OR4A47P | 65% | 304 |
| Horse | OR4A148P | 75% | 305 |
| Chimp | OR4A5P | 95% | 308 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC140750 |
| GNF Atlas2 | gnf1h05420_at |
Sequence information
| Nucleotide sequence |
ATGAGACAGAATAACAATATTACAGAATTTGTCCTCCTGGGCTTTTCTCAGGATCCTGGT GTGCAAAAAGCATTATTTGTCATGTTTTTACTCACATACTTGGTGACAGTGGTGGGGAAC CTGCTCATTGTGGTGGATATTATTGCCAGCCCTTCCTTGGGTTCCCCAATGTATTTCTTC CTTGCCTGCCTGTCATTTATAGATGCTGCATATTCCACTACCATTTCTCCCAAGTTAATT GTAGGCTTATTCTGTGATAAAAAGACTATTTCCTTCCAAGGTTGCATGGGCCAGCTATTT ATAGACCATTTCTTTGGTGGGGCTGAGGTCTTCCTTCTGGTGGTGATGGCCTGTGATCGC TATGTGGCCATCTGTAAGCCACTGCACTATTTGACCATCATGAATCGACAGGTTTGCTTC CTTCTGTTGGTGGTGGCCATGATTGGAGGTTTTGTACATTCTGCGTTTCAAATTGTTGTG TACAGTCTCCCTTTCTGTGGTCCCAATGTCATTGTTCATTTCAGTTGTGACATGCACCCA TTACTGGAACTGGCATGCACTGACACCTACTTTATAGGCCTCACTGTTGTTGTCAATAGT GGAGCAATCTGTATGGTCATTTTCAACCTTCTGTTAATCTCCTATGGAGTCATCCTAAGC TCCCTTAAAACTTACAGTCAGGAAAAGAGGGGTAAAGCCTTGTCTACCTGCAGCTCCGGC AGTACCGTTGTTGTCCTCTTTTTTGTACCCTGTATTTTCATATATGTTAGACCTGTTTCA AACTTTCCTACTGATAAGTTCATGACTGTGTTTTATACCATTATCACACACATGCTGAGT CCTTTAATATATACGTTGAGAAATTCAGAGATGAGAAATGCTATAGAAAAACTCTTGGGT AAAAAGTTAACTATATTTATTATAGGAGGAGTGTCCGTCCTCATG |
| Conceptual translation |
MRQNNNITEFVLLGFSQDPGVQKALFVMFLLTYLVTVVGNLLIVVDIIASPSLGSPMYFF LACLSFIDAAYSTTISPKLIVGLFCDKKTISFQGCMGQLFIDHFFGGAEVFLLVVMACDR YVAICKPLHYLTIMNRQVCFLLLVVAMIGGFVHSAFQIVVYSLPFCGPNVIVHFSCDMHP LLELACTDTYFIGLTVVVNSGAICMVIFNLLLISYGVILSSLKTYSQEKRGKALSTCSSG STVVVLFFVPCIFIYVRPVSNFPTDKFMTVFYTIITHMLSPLIYTLRNSEMRNAIEKLLG KKLTIFIIGGVSVLM Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 51,411,530 | 51,411,530 | nonsense SNP | G/T | S/* | rs5029499 (DbSNP) |
| 11 | 51,411,674 | 51,411,674 | NS | A/C | I/S | rs5011056 (DbSNP) |
| 11 | 51,411,662 | 51,411,662 | NS | A/G | V/A | rs5011058 (DbSNP) |
| 11 | 51,412,146 | 51,412,146 | NS | A/G | F/L | rs5002404 (DbSNP) |
| 11 | 51,411,584 | 51,411,584 | NS | A/G | F/S | rs5011059 (DbSNP) |
| 11 | 51,412,353 | 51,412,353 | NS | A/T | F/I | rs61890335 (DbSNP) |
| 11 | 51,411,740 | 51,411,740 | NS | A/T | L/Q | rs35083184 (DbSNP) |
| 11 | 51,412,327 | 51,412,327 | NS | A/T | N/K | rs56302591 (DbSNP) |
| 11 | 51,411,678 | 51,411,678 | NS | C/G | G/R | rs5011055 (DbSNP) |
| 11 | 51,411,705 | 51,411,705 | NS | C/G | G/R | rs5029501 (DbSNP) |
| 11 | 51,412,379 | 51,412,379 | NS | C/T | S/N | rs10902343 (DbSNP) |
| 11 | 51,412,151 | 51,412,151 | NS | C/T | G/D | rs5002403 (DbSNP) |
| 11 | 51,412,251 | 51,412,251 | NS | C/T | A/T | rs72482364 (DbSNP) |
| 11 | 51,411,704 | 51,411,704 | NS | C/T | G/D | rs5029500 (DbSNP) |
| 11 | 51,412,077 | 51,412,077 | NS | C/T | G/R | rs5002407 (DbSNP) |
| 11 | 51,411,914 | 51,411,914 | NS | C/T | C/Y | rs61890334 (DbSNP) |
| 11 | 51,412,118 | 51,412,118 | NS | G/T | P/Q | rs5002405 (DbSNP) |
| 11 | 51,411,667 | 51,411,667 | SYN | A/C | V/V | rs5011057 (DbSNP) |
| 11 | 51,412,075 | 51,412,075 | SYN | A/C | G/G | rs5002408 (DbSNP) |
| 11 | 51,411,561 | 51,411,561 | SYN | A/G | L/L | rs5011060 (DbSNP) |
| 11 | 51,412,066 | 51,412,066 | SYN | A/G | V/V | rs5002409 (DbSNP) |
| 11 | 51,412,078 | 51,412,078 | SYN | A/G | G/G | rs5002406 (DbSNP) |
| 11 | 51,411,544 | 51,411,544 | SYN | A/G | Y/Y | rs5011061 (DbSNP) |
| 11 | 51,411,940 | 51,411,940 | SYN | C/T | V/V | rs5002410 (DbSNP) |
| 11 | 51,411,460 | 51,411,460 | SYN | G/A | S/S | rs34285763 (DbSNP) |
| 11 | 54,707,461 | 54,707,461 | NS | C/T | G/D | 1000GP (CEU) |
| 11 | 54,707,413 | 54,707,413 | NS | T/C | D/G | 1000GP (CEU) |
| 11 | 54,707,539 | 54,707,539 | NS | A/T | L/Q | 1000GP (CEU, CHBJPT) |
| 11 | 54,707,819 | 54,707,819 | SYN | G/A | S/S | 1000GP (CEU, CHBJPT) |
| 11 | 100 | -100 | NS | A/T | L/Q | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 51,192,824 | 51,563,636 | CopyNumber | Variation_8689 (DGV) |
| 11 | 51,228,146 | 51,525,878 | CopyNumber | Variation_48823 (DGV) |
| 11 | 51,372,036 | 51,529,002 | CopyNumber | Variation_53111 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L219Q | Y161C | V160M | A62V | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | L | Y | V | A | 86.18 | 0.287 |
| 2 | Q | Y | V | A | 9.29 | 0.287 |
| 3 | L | C | V | A | 3.53 | 0.287 |
| 4 | L | Y | V | V | 0.54 | 0.287 |
| 5 | L | Y | M | A | 0.38 | 0.287 |
| 6 | Q | C | V | A | 0.08 | 0.287 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4A5.aApr07-unspliced | main_exon | CDS | chr11 | 54,706,884 | 54,707,828 | - |
| 3UTR | chr11 | 54,707,828 | 54,707,831 | - | ||