OR4M1 Olfactory Receptor
| Gene Symbol | OR4M11 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | M |
| Pseudogene | No |
| CORP pseudogene probability score | 0.14 (functional) |
| Aliases | OR14-7, HsOR14.1.5, ORL4966 |
| External Ids | HGNC: 14735 GeneBank: AB065886, BK004359, NM_001005500 ORDB: ORL4966 |
| Build #39 labels | OR4M1 |
| Chromosomal location | 14:19,780,323-19,781,261 (+) |
| Cluster | 14@20b |
| Synteny | CLIC#32 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4M2 | 93.93% | 313 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4N5 | 61% | 310 |
| Mouse | Or4m1 | 91% | 313 |
| Rat | Or4m1 | 92% | 313 |
| Cow | OR4N5 | 61% | 310 |
| Orang | OR4M1B | 97% | 313 |
| Orang | OR4M1C | 96% | 313 |
| Horse | OR4N2D | 61% | 308 |
| Chimp | OR4N5 | 62% | 310 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136987 |
Sequence information
| Nucleotide sequence |
ATGGAAACTGCAAATTACACCAAGGTGACAGAATTTGTTCTCACTGGCCTATCCCAGACT CGGGAGGTCCAACTAGTCCTATTTGTTATATTTCTATCCTTCTATTTGTTCATCCTACCA GGAAATATCCTTATCATTTGCACCATCAGGCTAGACCCTCATCTGACTTCTCCTATGTAT TTCCTGTTGGCTAATCTGGCCCTCCTTGATATTTGGTACTCTTCCATTACAGCCCCTAAA ATGCTCATAGACTTCTTTGTGGAGAGGAAGATAATTTCCTTTGGTGGATGCATTGCACAG CTCTTCTTCTTACACTTTGTTGGGGCTTCGGAGATGTTCTTGCTCACAGTGATGGCCTAT GACCGCTATGCTGCTATCTGCCGACCCCTCCACTATGCTACCATCATGAATCGACGTCTC TGCTGTATCCTGGTGGCTCTCTCCTGGATGGGGGGCTTCATTCATTCTATAATACAGGTG GCTCTCATTGTTCGACTTCCTTTCTGTGGGCCCAATGAGTTAGACAGTTACTTCTGTGAC ATCACACAGGTTGTCCGGATTGCCTGTGCCAACACCTTCCCAGAGGAGTTAGTGATGATC TGTAGTAGTGGTCTGATCTCTGTGGTGTGTTTCATTGCTCTGTTAATGTCCTATGCCTTC CTTCTGGCCTTGCTCAAGAAACATTCAGGCTCAGGTGAGAATACCAACAGGGCCATGTCC ACCTGCTATTCCCACATTACCATTGTGGTGCTAATGTTTGGGCCATCCATCTACATTTAT GCTCGCCCATTTGACTCATTTTCCCTAGATAAAGTGGTGTCTGTGTTTCATACTGTAATA TTCCCTTTACTTAATCCCATTATTTACACATTGAGAAACAAGGAAGTAAAGGCAGCCATG AGGAAGGTGGTCACCAAATATATTTTGTGTGAAGAGAAG |
| Conceptual translation |
METANYTKVTEFVLTGLSQTREVQLVLFVIFLSFYLFILPGNILIICTIRLDPHLTSPMY FLLANLALLDIWYSSITAPKMLIDFFVERKIISFGGCIAQLFFLHFVGASEMFLLTVMAY DRYAAICRPLHYATIMNRRLCCILVALSWMGGFIHSIIQVALIVRLPFCGPNELDSYFCD ITQVVRIACANTFPEELVMICSSGLISVVCFIALLMSYAFLLALLKKHSGSGENTNRAMS TCYSHITIVVLMFGPSIYIYARPFDSFSLDKVVSVFHTVIFPLLNPIIYTLRNKEVKAAM RKVVTKYILCEEK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 14 | 20,248,768 | 20,248,768 | NS | A/G | E/G | rs62619918 (DbSNP) |
| 14 | 20,249,310 | 20,249,310 | NS | C/A | H/N | rs3968186 (DbSNP) |
| 14 | 20,248,828 | 20,248,828 | NS | C/T | T/I | rs2635535 (DbSNP) |
| 14 | 20,249,176 | 20,249,176 | NS | G/A | G/D | rs2815960 (DbSNP) |
| 14 | 20,249,412 | 20,249,412 | NS | G/A | E/K | rs2318549 (DbSNP) |
| 14 | 20,249,316 | 20,249,316 | NS | T/G | L/V | rs3968196 (DbSNP) |
| 14 | 20,249,309 | 20,249,309 | SYN | T/C | F/F | rs3968187 (DbSNP) |
| 14 | 19,780,524 | 19,780,524 | NS | C/T | L/F | 1000GP (CEU) |
| 14 | 19,780,669 | 19,780,669 | NS | C/T | T/I | 1000GP (CEU, CHBJPT) |
| 14 | 100 | -100 | NS | G/A | A/T | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 14 | 20,197,616 | 20,399,048 | CopyNumber | Variation_0316 (DGV) |
| 14 | 20,203,125 | 20,539,108 | CopyNumber | Variation_3036 (DGV) |
| 14 | 19,662,531 | 20,556,187 | CopyNumber | Variation_3929 (DGV) |
| 14 | 20,080,166 | 20,271,356 | CopyNumber | Variation_4824 (DGV) |
| 14 | 20,219,649 | 20,415,445 | CopyNumber | Variation_4826 (DGV) |
| 14 | 19,117,183 | 20,424,605 | CopyNumber | Variation_7028 (DGV) |
| 14 | 20,203,125 | 20,483,660 | CopyNumber | Variation_8762 (DGV) |
| 14 | 20,203,125 | 20,626,160 | CopyNumber | Variation_8763 (DGV) |
| 14 | 20,239,479 | 20,422,583 | CopyNumber | Variation_8764 (DGV) |
| 14 | 20,203,125 | 20,716,841 | CopyNumber | Variation_8765 (DGV) |
| 14 | 20,203,125 | 20,433,044 | CopyNumber | Variation_9234 (DGV) |
| 14 | 20,239,479 | 20,511,107 | CopyNumber | Variation_9235 (DGV) |
| 14 | 20,177,234 | 20,424,604 | CopyNumber | Variation_30648 (DGV) |
| 14 | 19,360,239 | 20,424,604 | CopyNumber | Variation_31953 (DGV) |
| 14 | 20,203,125 | 20,525,833 | CopyNumber | Variation_34547 (DGV) |
| 14 | 20,203,125 | 20,456,434 | CopyNumber | Variation_34575 (DGV) |
| 14 | 20,203,125 | 20,655,466 | CopyNumber | Variation_34656 (DGV) |
| 14 | 20,239,246 | 20,432,988 | CopyNumber | Variation_34659 (DGV) |
| 14 | 20,203,125 | 20,550,348 | CopyNumber | Variation_34660 (DGV) |
| 14 | 20,203,125 | 20,455,307 | CopyNumber | Variation_34664 (DGV) |
| 14 | 19,670,757 | 20,331,117 | CopyNumber | Variation_37621 (DGV) |
| 14 | 20,200,183 | 20,423,372 | CopyNumber | Variation_38951 (DGV) |
| 14 | 19,349,922 | 20,424,856 | CopyNumber | Variation_58655 (DGV) |
| 14 | 20,177,210 | 20,424,753 | CopyNumber | Variation_66584 (DGV) |
| 14 | 20,194,500 | 20,255,301 | CopyNumber | Variation_71832 (DGV) |
| 14 | 19,781,170 | 20,424,776 | CopyNumber | Variation_71833 (DGV) |
| 14 | 20,198,061 | 20,307,453 | CopyNumber | Variation_71859 (DGV) |
| 14 | 20,152,622 | 20,419,574 | CopyNumber | Variation_76554 (DGV), Variation_87112 (DGV) |
| 14 | 20,185,336 | 20,310,638 | CopyNumber | Variation_76557 (DGV) |
| 14 | 20,179,862 | 20,261,582 | CopyNumber | Variation_87116 (DGV) |
| 14 | 20,201,654 | 20,343,302 | CopyNumber | Variation_87118 (DGV) |
| CopyNumber | 195 (Hasin) | |||
| 14 | 20,248,382 | 20,251,420 | CopyNumber | #166 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L44F | A64T | T116I | I157T | V208M | G232D | R262H | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | L | A | T | I | V | G | R | 72.27 | 0.259 |
| 2 | L | A | I | I | V | D | R | 24.73 | 0.259 |
| 3 | L | A | T | T | V | G | R | 0.69 | 0.259 |
| 4 | L | T | T | I | M | G | R | 0.69 | 0.259 |
| 5 | L | A | T | I | V | D | R | 0.61 | 0.259 |
| 6 | L | A | T | I | V | G | H | 0.54 | 0.259 |
| 7 | L | A | I | I | V | G | R | 0.23 | 0.259 |
| 8 | F | A | T | I | V | G | R | 0.15 | 0.259 |
| 9 | L | T | T | I | V | G | R | 0.08 | 0.259 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4M1.aApr07-unspliced | main_exon | CDS | chr14 | 19,780,323 | 19,781,261 | + |
| 3UTR | chr14 | 19,781,261 | 19,781,264 | + | ||