OR4M2 Olfactory Receptor
| Gene Symbol | OR4M21 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | M |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR15-3, HsOR15.1.8, ORL3723 |
| External Ids | HGNC: 15373 GeneBank: AB065903, BK004480, NM_001004719 ORDB: ORL3723 |
| Build #39 labels | OR4M2 |
| Chromosomal location | 15:22,080,625-22,081,563 (+) |
| Cluster | 15@22 |
| Synteny | CLIC#32 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4M1 | 93.93% | 313 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4M1 | 90% | 312 |
| Mouse | Or4m1 | 88% | 313 |
| Rat | Or4m1 | 89% | 313 |
| Cow | OR4M1 | 90% | 313 |
| Orang | OR4M1 | 94% | 313 |
| Orang | OR4M1B | 94% | 313 |
| Orang | OR4M1C | 93% | 313 |
| Horse | OR4M1 | 90% | 313 |
| Chimp | OR4N5 | 61% | 310 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | CR746505 |
| mRNA | BC136985 |
| GNF Atlas2 | gnf1h02900_s_at |
Sequence information
| Nucleotide sequence |
ATGGAAACTGCAAATTACACCAAGGTGACAGAATTTGTTCTCACTGGCCTATCCCAGACT CCAGAGGTCCAACTAGTCCTATTTGTTATATTTCTATCCTTCTATTTGTTCATCCTACCA GGAAATATCCTTATCATTTGCACCATCAGTCTAGACCCTCATCTGACCTCTCCTATGTAT TTCCTGTTGGCTAATCTGGCCTTCCTTGATATTTGGTACTCTTCCATTACAGCCCCTGAA ATGCTCATAGACTTCTTTGTGGAGAGGAAGATAATTTCTTTTGATGGATGCATTGCACAG CTCTTCTTCTTACACTTTGCTGGGGCTTCGGAGATGTTCTTGCTCACAGTGATGGCCTTT GACCTCTACACTGCTATCTGCCGACCCCTCCACTATGCTACCATCATGAATCAACGTCTC TGCTGTATCCTGGTGGCTCTCTCCTGGAGGGGGGGCTTCATTCATTCTATCATACAGGTG GCTCTCATTGTTCGACTTCCTTTCTGTGGGCCCAATGAGTTAGACAGTTACTTCTGTGAC ATCACACAGGTTGTCCGGATTGCCTGTGCCAACACCTTCCCAGAGGAGTTAGTGATGATC TGTAGTAGTGGTCTGATCTCTGTGGTGTGTTTGATTGCTCTGTTAATGTCCTATGCCTTC CTTCTGGCCTTGTTCAAGAAACTTTCAGGCTCAGGTGAGAATACCAACAGGGCCATGTCC ACCTGCTATTCCCACATTACCATTGTGGTGCTAATGTTTGGGCCATCCATCTACATTTAT GCTCGCCCATTTGACTCGTTTTCCCTAGATAAAGTGGTGTCTGTGTTCAATACTTTAATA TTCCCTTTACGTAATCCCATTATTTACACATTGAGAAACAAGGAAGTAAAGGCAGCCATG AGGAAGTTGGTCACCAAATATATTTTGTGTAAAGAGAAG |
| Conceptual translation |
METANYTKVTEFVLTGLSQTPEVQLVLFVIFLSFYLFILPGNILIICTISLDPHLTSPMY FLLANLAFLDIWYSSITAPEMLIDFFVERKIISFDGCIAQLFFLHFAGASEMFLLTVMAF DLYTAICRPLHYATIMNQRLCCILVALSWRGGFIHSIIQVALIVRLPFCGPNELDSYFCD ITQVVRIACANTFPEELVMICSSGLISVVCLIALLMSYAFLLALFKKLSGSGENTNRAMS TCYSHITIVVLMFGPSIYIYARPFDSFSLDKVVSVFNTLIFPLRNPIIYTLRNKEVKAAM RKLVTKYILCKEK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 15 | 100 | -100 | NS | G/A | R/H | 1000GP (YRI) |
| 15 | 100 | -100 | SYN | C/T | L/L | 1000GP (YRI, YRI, YRI, YRI) |
| 15 | 22,080,904 | 22,080,904 | NS | T/C | F/L | 1000GP (CHBJPT) |
| 15 | 22,080,911 | 22,080,911 | NS | G/A | G/E | 1000GP (CHBJPT) |
| 15 | 22,080,954 | 22,080,954 | SYN | G/A | S/S | 1000GP (CEU, CHBJPT) |
| 15 | 22,081,006 | 22,081,006 | nonsense SNP | C/T | R/* | 1000GP (CEU, CHBJPT) |
| 15 | 22,081,475 | 22,081,475 | NS | G/A | R/H | 1000GP (CEU, CHBJPT) |
| 15 | 22,368,738 | 22,368,738 | SYN | C/T | L/L | rs17157554 (DbSNP) |
| 15 | 22,368,862 | 22,368,862 | NS | G/A | G/E | rs1835183 (DbSNP) |
| 15 | 22,368,905 | 22,368,905 | SYN | G/A | S/S | rs1835182 (DbSNP) |
| 15 | 22,368,936 | 22,368,936 | NS | A/G | N/D | rs11857531 (DbSNP) |
| 15 | 22,369,248 | 22,369,248 | NS | T/C | F/L | rs491208 (DbSNP) |
| 15 | 22,369,279 | 22,369,279 | NS | C/G | T/S | rs28678403 (DbSNP) |
| 15 | 22,369,290 | 22,369,290 | NS | A/G | M/V | rs12593418 (DbSNP) |
| 15 | 22,369,343 | 22,369,343 | SYN | C/T | S/S | rs11259845 (DbSNP) |
| 15 | 22,369,373 | 22,369,373 | SYN | A/G | S/S | rs10048049 (DbSNP) |
| 15 | 22,369,426 | 22,369,426 | NS | G/A | R/H | rs4087943 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 15 | 20,003,725 | 23,814,757 | CopyNumber | Variation_3951 (DGV) |
| 15 | 20,143,651 | 23,690,892 | CopyNumber | Variation_3070 (DGV) |
| 15 | 20,161,372 | 22,449,059 | CopyNumber | Variation_49468 (DGV), Variation_49469 (DGV) |
| 15 | 20,161,372 | 22,755,185 | CopyNumber | Variation_49470 (DGV) |
| 15 | 20,161,372 | 23,226,254 | CopyNumber | Variation_49471 (DGV) |
| 15 | 20,167,086 | 22,588,036 | CopyNumber | Variation_8779 (DGV) |
| 15 | 20,167,086 | 22,862,959 | CopyNumber | Variation_34576 (DGV) |
| 15 | 20,167,086 | 22,869,764 | CopyNumber | Variation_8781 (DGV) |
| 15 | 20,167,086 | 23,222,284 | CopyNumber | Variation_9251 (DGV), Variation_34504 (DGV) |
| 15 | 20,167,086 | 23,854,707 | CopyNumber | Variation_8784 (DGV) |
| 15 | 20,167,089 | 22,588,036 | CopyNumber | Variation_9250 (DGV) |
| 15 | 20,167,089 | 22,869,763 | CopyNumber | Variation_34665 (DGV) |
| 15 | 20,167,089 | 23,222,284 | CopyNumber | Variation_34608 (DGV) |
| 15 | 20,171,787 | 22,646,418 | CopyNumber | Variation_31980 (DGV) |
| 15 | 20,198,198 | 22,591,284 | CopyNumber | Variation_30670 (DGV) |
| 15 | 20,266,957 | 22,674,466 | CopyNumber | Variation_0318 (DGV) |
| 15 | 20,397,403 | 22,698,551 | CopyNumber | Variation_7046 (DGV) |
| 15 | 20,422,586 | 22,588,019 | CopyNumber | Variation_34663 (DGV) |
| 15 | 20,541,678 | 22,368,898 | CopyNumber | Variation_58702 (DGV) |
| 15 | 20,610,110 | 22,575,858 | Inversion | Variation_0443 (DGV) |
| 15 | 20,625,544 | 22,559,977 | Inversion | Variation_0444 (DGV) |
| 15 | 20,851,594 | 22,588,036 | CopyNumber | Variation_34545 (DGV) |
| 15 | 20,852,150 | 23,222,284 | CopyNumber | Variation_8785 (DGV) |
| 15 | 20,879,638 | 22,777,875 | CopyNumber | Variation_9254 (DGV) |
| 15 | 20,935,075 | 22,777,875 | CopyNumber | Variation_8783 (DGV) |
| 15 | 21,012,524 | 23,222,284 | CopyNumber | Variation_9256 (DGV) |
| 15 | 21,054,356 | 22,453,425 | CopyNumber | Variation_76814 (DGV), Variation_87462 (DGV) |
| 15 | 21,072,035 | 22,588,019 | CopyNumber | Variation_34607 (DGV) |
| 15 | 21,097,124 | 22,449,059 | CopyNumber | Variation_9742 (DGV) |
| 15 | 21,200,251 | 22,588,036 | CopyNumber | Variation_8786 (DGV) |
| 15 | 21,276,422 | 22,453,425 | CopyNumber | Variation_87468 (DGV) |
| 15 | 21,362,809 | 22,453,425 | CopyNumber | Variation_76815 (DGV) |
| 15 | 22,262,145 | 22,453,425 | CopyNumber | Variation_76813 (DGV) |
| 15 | 22,262,185 | 22,373,349 | CopyNumber | Variation_72167 (DGV) |
| 15 | 22,262,185 | 22,596,129 | CopyNumber | Variation_72162 (DGV) |
| 15 | 22,265,649 | 22,591,752 | CopyNumber | Variation_37535 (DGV), Variation_37626 (DGV) |
| 15 | 22,286,537 | 22,453,425 | CopyNumber | Variation_87461 (DGV) |
| 15 | 22,287,131 | 22,399,235 | CopyNumber | Variation_59598 (DGV) |
| 15 | 22,302,006 | 22,588,022 | CopyNumber | Variation_38952 (DGV) |
| 15 | 22,304,940 | 22,427,590 | CopyNumber | Variation_72152 (DGV) |
| 15 | 22,307,069 | 22,474,088 | CopyNumber | Variation_2182 (DGV) |
| 15 | 22,320,036 | 22,588,036 | CopyNumber | Variation_8782 (DGV), Variation_34557 (DGV) |
| 15 | 22,320,057 | 22,588,019 | CopyNumber | Variation_9249 (DGV), Variation_34643 (DGV) |
| 15 | 22,320,057 | 22,777,875 | CopyNumber | Variation_9252 (DGV) |
| 15 | 22,343,976 | 22,373,055 | CopyNumber | Variation_72153 (DGV) |
| 15 | 22,348,218 | 22,544,992 | CopyNumber | Variation_4873 (DGV) |
| 15 | 22,351,239 | 22,449,059 | CopyNumber | Variation_9741 (DGV), Variation_10464 (DGV) |
| 15 | 22,368,476 | 22,371,514 | CopyNumber | #165 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| N5D | L44R | F94L | A109V | D121N | R128* | T235S | M239V | R284C | R284H | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | N | L | F | A | D | R | T | M | R | R | 41.71 | 0.954 |
| 2 | N | L | F | A | D | R | T | M | R | H | 25.65 | 0.954 |
| 3 | N | L | F | A | D | R | T | V | R | H | 20.51 | 0.954 |
| 4 | N | L | L | A | D | * | T | M | R | R | 4.38 | 1.200 |
| 5 | N | L | F | A | D | R | S | M | R | R | 1.31 | 0.954 |
| 6 | N | L | F | A | D | R | S | M | R | H | 0.77 | 0.954 |
| 7 | D | L | F | A | D | R | T | M | R | R | 0.77 | 0.954 |
| 8 | N | L | L | A | D | * | T | M | R | H | 0.69 | 1.200 |
| 9 | N | L | L | A | D | R | T | M | R | R | 0.69 | 0.954 |
| 10 | N | L | F | A | D | R | T | V | R | R | 0.61 | 0.954 |
| 11 | N | L | F | A | D | R | T | M | C | R | 0.61 | 0.954 |
| 12 | N | L | F | V | D | R | T | M | R | R | 0.46 | 0.954 |
| 13 | N | L | F | A | D | * | T | M | R | R | 0.46 | 1.200 |
| 14 | N | L | F | A | D | R | T | M | C | H | 0.31 | 0.954 |
| 15 | N | L | F | A | N | R | T | M | R | R | 0.23 | 1.000 |
| 16 | D | L | L | A | D | * | T | M | R | R | 0.15 | 1.200 |
| 17 | N | L | F | A | D | * | T | M | R | H | 0.15 | 1.200 |
| 18 | D | L | F | A | D | R | T | M | R | H | 0.08 | 0.954 |
| 19 | N | R | F | A | D | R | T | V | R | H | 0.08 | 0.954 |
| 20 | N | L | L | A | D | * | T | V | R | H | 0.08 | 1.200 |
| 21 | D | L | F | A | D | R | T | V | R | H | 0.08 | 0.954 |
| 22 | N | L | L | A | D | R | T | M | R | H | 0.08 | 0.954 |
| 23 | N | L | F | V | N | R | T | M | R | R | 0.08 | 1.000 |
| 24 | N | L | F | A | D | R | S | V | R | H | 0.08 | 0.954 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4Q1PandOR4M2andOR4N4.bApr07-unspliced | main_exon | CDS | chr15 | 22,080,625 | 22,081,563 | + |
| 3UTR | chr15 | 22,081,563 | 22,081,566 | + | ||
| OR4Q1PandOR4M2andOR4N4.nApr07 | exon_5UTR | chr15 | 22,070,241 | 22,070,454 | + | |
| main_exon | chr15 | 22,080,596 | 22,080,648 | + | ||
| main_exon | 5UTR | chr15 | 22,080,596 | 22,080,625 | + | |
| CDS_partial | chr15 | 22,080,625 | 22,080,648 | + | ||
| CDS_partial | chr15 | 22,080,857 | 22,081,069 | + | ||