OR4X1 Olfactory Receptor
| Gene Symbol | OR4X11 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | X |
| Pseudogene | No |
| CORP pseudogene probability score | 0.03 (functional) |
| Aliases | OR11-104, HsOR11.8.4, ORL3323 |
| External Ids | HGNC: 14854 GeneBank: AB065544, BK004388, NM_001004726 ORDB: ORL3323 |
| Build #39 labels | OR4X1 |
| Chromosomal location | 11:48,263,861-48,264,775 (+) |
| Cluster | 11@48 |
| Synteny | CLIC#26 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP rs10838851 (AA change=Y/* ) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4X2 | 63.01% | 292 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4X5 | 76% | 305 |
| Mouse | Or4x5-ps | 78% | 304 |
| Rat | Or4x5 | 78% | 304 |
| Cow | OR4X5 | 78% | 303 |
| Orang | OR4X2P | 63% | 292 |
| Horse | OR4X2C | 65% | 298 |
| Chimp | OR4X1P | 98% | 305 |
Expression evidences
| Source | Accession |
|---|---|
| GNF Atlas2 | gnf1h02095_at |
Sequence information
| Nucleotide sequence |
ATGGTTGCTACAAACAATGTGACTGAAATAATTTTCGTGGGATTTTCCCAGAATTGGAGT GAGCAGAGGGTCATTTCTGTGATGTTTCTCCTCATGTACACAGCTGTTGTGCTGGGCAAT GGCCTCATTGTGGTGACCATCCTGGCCAGCAAAGTGCTCACCTCCCCCATGTATTTCTTT CTCAGCTACTTATCCTTTGTGGAGATCTGCTACTGTTCTGTCATGGCCCCCAAGCTTATC TTTGACTCCTTTATCAAGAGGAAAGTCATTTCTCTCAAGGGCTGCCTCACACAGATGTTT TCCCTCCATTTCTTTGGTGGCACTGAGGCCTTTCTCCTGATGGTGATGGCCTATGACCGC TATGTGGCCATCTGCAAGCCCTTGCACTACATGGCCATCATGAACCAGCGAATGTGTGGT CTCCTCGTGAGGATAGCATGGGGCGGGGGCCTGCTGCATTCTGTTGGGCAAACCTTCCTG ATTTTCCAGCTCCCGTTCTGTGGCCCCAACATCATGGACCACTACTTCTGTGATGTCCAC CCAGTGCTGGAGCTGGCCTGCGCAGACACCTTCTTCATTAGCCTGCTGATCATCACCAAT GGCGGCTCCATCTCCGTAGTCAGTTTCTTCGTGCTGATGGCTTCCTACCTGATCATCCTG CACTTCCTGAGAAGCCACAACTTGGAGGGGCAGCACAAGGCCCTCTCCACCTGTGCCTCT CATGTCACAGTTGTCGACCTGTTCTTCATACCTTGCTCCTTGGTCTATATTAGGCCCTGT GTCACCCTCCCTGCAGACAAGATAGTTGCTGTATTTTATACAGTGGTCACACCTCTCTTA AACCCTGTGATTTACTCCTTCAGGAATGCTGAAGTGAAAAATGCCATGAGGAGATTTATT GGGGGAAAAGTAATT |
| Conceptual translation |
MVATNNVTEIIFVGFSQNWSEQRVISVMFLLMYTAVVLGNGLIVVTILASKVLTSPMYFF LSYLSFVEICYCSVMAPKLIFDSFIKRKVISLKGCLTQMFSLHFFGGTEAFLLMVMAYDR YVAICKPLHYMAIMNQRMCGLLVRIAWGGGLLHSVGQTFLIFQLPFCGPNIMDHYFCDVH PVLELACADTFFISLLIITNGGSISVVSFFVLMASYLIILHFLRSHNLEGQHKALSTCAS HVTVVDLFFIPCSLVYIRPCVTLPADKIVAVFYTVVTPLLNPVIYSFRNAEVKNAMRRFI GGKVI Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 48,285,986 | 48,285,988 | Del(3) | -/TTC | rs57294041 (DbSNP) | |
| 11 | 48,286,231 | 48,286,231 | nonsense SNP | A/T | */Y | rs10838851 (DbSNP) |
| 11 | 48,285,995 | 48,285,995 | NS | A/C | M/L | rs12796846 (DbSNP) |
| 11 | 48,285,959 | 48,285,959 | NS | A/C | M/L | rs12796681 (DbSNP) |
| 11 | 48,286,086 | 48,286,086 | NS | A/G | N/S | rs61746892 (DbSNP) |
| 11 | 48,286,148 | 48,286,148 | NS | A/G | N/D | rs17199104 (DbSNP) |
| 11 | 48,286,043 | 48,286,043 | NS | A/G | M/V | rs61915300 (DbSNP) |
| 11 | 48,285,740 | 48,285,740 | NS | A/G | T/A | rs61747640 (DbSNP) |
| 11 | 48,285,999 | 48,285,999 | NS | A/T | Q/L | rs12798361 (DbSNP) |
| 11 | 48,285,965 | 48,285,965 | NS | C/G | L/V | rs12796828 (DbSNP) |
| 11 | 48,286,256 | 48,286,256 | NS | C/T | P/S | rs10838852 (DbSNP) |
| 11 | 48,285,906 | 48,285,906 | NS | C/T | P/L | rs16905753 (DbSNP) |
| 11 | 48,285,842 | 48,285,842 | NS | G/A | G/R | rs1503193 (DbSNP) |
| 11 | 48,286,234 | 48,286,234 | SYN | A/G | T/T | rs61732322 (DbSNP) |
| 11 | 48,285,856 | 48,285,856 | SYN | C/T | G/G | rs10838850 (DbSNP) |
| 11 | 48,285,424 | 48,285,424 | SYN | G/A | T/T | rs713323 (DbSNP) |
| 11 | 48,264,679 | 48,264,679 | nonsense SNP | T/A | Y/* | 1000GP (CEU, CHBJPT) |
| 11 | 48,264,218 | 48,264,218 | NS | C/T | R/C | 1000GP (CEU) |
| 11 | 48,264,304 | 48,264,304 | SYN | C/T | G/G | 1000GP (CEU, CHBJPT) |
| 11 | 48,264,290 | 48,264,290 | NS | A/G | R/G | 1000GP (CEU, CHBJPT) |
| 11 | 48,264,354 | 48,264,354 | NS | C/T | P/L | 1000GP (CEU, CHBJPT) |
| 11 | 48,264,653 | 48,264,653 | NS | G/C | A/P | 1000GP (CEU) |
| 11 | 48,264,704 | 48,264,704 | NS | C/T | P/S | 1000GP (CEU, CHBJPT) |
| 11 | 48,264,692 | 48,264,692 | NS | C/A | P/T | 1000GP (CEU) |
| 11 | 48,264,682 | 48,264,682 | SYN | A/G | T/T | 1000GP (CEU) |
| 11 | 100 | -100 | SYN | A/G | T/T | 1000GP (YRI, YRI) |
| 11 | 100 | -100 | NS | G/A | A/T | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | nonsense SNP | T/A | Y/* | 1000GP (YRI) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| A49V | A110T | R120C | V143M | R144G | P165L | S225N | D246N | Y256C | A265P | Y273* | P282S | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | A | A | R | V | G | P | S | D | Y | A | * | S | 40.17 | 1.200 |
| 2 | A | A | R | V | G | P | S | D | Y | A | Y | P | 32.87 | 0.093 |
| 3 | A | A | R | V | G | L | S | D | Y | A | * | P | 15.82 | 1.200 |
| 4 | A | A | R | V | G | P | S | D | Y | A | * | P | 4.07 | 1.200 |
| 5 | A | A | R | V | G | P | N | D | Y | A | * | S | 3.38 | 1.200 |
| 6 | A | A | R | V | R | P | S | D | Y | A | Y | P | 1.08 | 0.093 |
| 7 | A | A | C | V | G | P | S | D | Y | A | Y | P | 0.77 | 0.645 |
| 8 | A | A | R | V | G | L | S | N | Y | A | * | P | 0.46 | 1.200 |
| 9 | A | T | R | V | G | P | S | D | Y | A | Y | P | 0.31 | 0.093 |
| 10 | A | A | R | V | G | L | S | D | C | A | * | P | 0.23 | 1.200 |
| 11 | A | A | R | V | G | P | S | N | Y | A | * | S | 0.23 | 1.200 |
| 12 | V | A | R | V | G | P | S | D | Y | A | * | S | 0.23 | 1.200 |
| 13 | A | A | R | V | G | L | S | D | Y | A | * | S | 0.15 | 1.200 |
| 14 | A | A | R | M | G | P | S | D | Y | A | * | S | 0.15 | 1.200 |
| 15 | A | A | R | V | G | P | S | D | Y | P | * | S | 0.08 | 1.200 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4X1.aApr07-unspliced | main_exon | CDS | chr11 | 48,263,861 | 48,264,775 | + |
| 3UTR | chr11 | 48,264,775 | 48,264,778 | + | ||