OR52E6 Olfactory Receptor
| Gene Symbol | OR52E61 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | E |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR11-58, HsOR11.3.84, ORL3386 |
| External Ids | HGNC: 15215 GeneBank: AB065815, AF399504, BK004304, NM_001005167 ORDB: ORL3386 |
| Build #39 labels | OR52E6 |
| Chromosomal location | 11:5,840,959-5,841,897 (-) |
| Cluster | 11@6 |
| Synteny | CLIC#23 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52E8 | 89.14% | 313 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52E8 | 87% | 312 |
| Dog | OR52E8C | 86% | 312 |
| Mouse | Or52e8b | 82% | 313 |
| Mouse | Or52e8 | 81% | 313 |
| Rat | Or52e8b | 82% | 313 |
| Rat | Or52e8 | 81% | 312 |
| Cow | OR52E8 | 82% | 309 |
| Orang | OR52E3 | 64% | 310 |
| Horse | OR52E20P | 70% | 311 |
| Chimp | OR52E8 | 89% | 313 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | EG357698 |
Sequence information
| Nucleotide sequence |
ATGCCTATAGCTAACGACACCCAGTTCCATACTTCTTCATTCCTACTGCTGGGTATCCCA GGGCTAGAAGATGTGCACATCTGGATTGGATTCCCTTTTTTCTCTGTGTATCTTATTGCA CTCCTGGGAAATGCTGCTATCTTCTTTGTGATCCAAACTGAGCAGAGTCTCCATGAGCCC ATGTACTACTGCCTGGCCATGTTGGATTCCATTGACCTGAGCTTGTCTACGGCCACCATT CCCAAAATGCTGGGCATCTTCTGGTTCAATATCAAGGAAATATCTTTTGGAGGCTACCTT TCTCAGATGTTCTTCATCCATTTCTTCACTGTCATGGAGAGCATCGTATTGGTGGCCATG GCCTTTGACCGCTACATTGCCATTTGCAAACCTCTTTGGTACACCATGATCCTCACCAGC AAAATCATCAGCCTCATTGCAGGCATTGCTGTCCTGAGGAGCTTGTACATGGTCATTCCA CTGGTGTTTCTCCTCTTAAGGTTGCCCTTCTGTGGACATCGTATCATCCCTCATACTTAC TGTGAGCACATGGGCATTGCCCGTCTGGCCTGTGCCAGCATCAAAGTCAACATTATGTTT GGTCTTGGCAGTATTTCTCTCTTGTTATTGGATGTGCTCCTTATTATTCTCTCCCATATC AGGATCCTCTATGCTGTCTTCTGCCTGCCCTCCTGGGAAGCTCGACTCAAAGCTCTCAAC ACCTGTGGCTCTCACATTGGTGTTATCTTAGCCTTTTCTACACCAGCATTTTTCTCTTTC TTTACACACTGCTTTGGCCATGATATTCCCCAATATATCCACATTTTCTTGGCTAATCTA TATGTGGTTGTTCCTCCCACCCTCAATCCTGTAATCTATGGGGTCAGAACCAAACATATT AGGGAGACAGTGCTGAGGATTTTCTTCAAGACAGATCAC |
| Conceptual translation |
MPIANDTQFHTSSFLLLGIPGLEDVHIWIGFPFFSVYLIALLGNAAIFFVIQTEQSLHEP MYYCLAMLDSIDLSLSTATIPKMLGIFWFNIKEISFGGYLSQMFFIHFFTVMESIVLVAM AFDRYIAICKPLWYTMILTSKIISLIAGIAVLRSLYMVIPLVFLLLRLPFCGHRIIPHTY CEHMGIARLACASIKVNIMFGLGSISLLLLDVLLIILSHIRILYAVFCLPSWEARLKALN TCGSHIGVILAFSTPAFFSFFTHCFGHDIPQYIHIFLANLYVVVPPTLNPVIYGVRTKHI RETVLRIFFKTDH Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 5,862,937 | 5,862,937 | NS | A/C | F/C | rs4495918 (DbSNP) |
| 11 | 5,862,532 | 5,862,532 | NS | A/C | M/R | rs10742809 (DbSNP) |
| 11 | 5,862,731 | 5,862,731 | NS | A/G | W/R | rs10838719 (DbSNP) |
| 11 | 5,862,845 | 5,862,845 | NS | A/G | S/P | rs4592451 (DbSNP) |
| 11 | 5,862,619 | 5,862,619 | NS | A/T | F/Y | rs7943698 (DbSNP) |
| 11 | 5,862,984 | 5,862,984 | NS | C/G | L/F | rs10769272 (DbSNP) |
| 11 | 5,862,965 | 5,862,965 | NS | C/G | E/Q | rs61739208 (DbSNP) |
| 11 | 5,863,013 | 5,863,013 | NS | C/T | V/I | rs4362173 (DbSNP) |
| 11 | 5,862,416 | 5,862,416 | NS | C/T | A/T | rs61735020 (DbSNP) |
| 11 | 5,862,653 | 5,862,653 | NS | C/T | V/I | rs4357719 (DbSNP) |
| 11 | 5,862,238 | 5,862,238 | NS | G/A | T/I | rs61739213 (DbSNP) |
| 11 | 5,862,758 | 5,862,758 | NS | G/A | R/C | rs61737712 (DbSNP) |
| 11 | 5,862,995 | 5,862,995 | NS | T/C | T/A | rs61737905 (DbSNP) |
| 11 | 5,863,113 | 5,863,113 | SYN | A/G | N/N | rs10742810 (DbSNP) |
| 11 | 5,862,780 | 5,862,780 | SYN | C/T | V/V | rs4362172 (DbSNP) |
| 11 | 5,841,707 | 5,841,707 | NS | C/A | C/F | 1000GP (CEU, CHBJPT) |
| 11 | 5,841,754 | 5,841,754 | NS | G/C | F/L | 1000GP (CEU, CHBJPT) |
| 11 | 5,841,883 | 5,841,883 | SYN | G/A | N/N | 1000GP (CEU, CHBJPT) |
| 11 | 5,841,615 | 5,841,615 | NS | A/G | S/P | 1000GP (CEU, CHBJPT) |
| 11 | 5,841,302 | 5,841,302 | NS | A/C | M/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,841,501 | 5,841,501 | NS | A/G | W/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,841,423 | 5,841,423 | NS | T/C | I/V | 1000GP (CEU, CHBJPT) |
| 11 | 5,841,783 | 5,841,783 | NS | T/C | I/V | 1000GP (CEU, CHBJPT) |
| 11 | 5,841,550 | 5,841,550 | SYN | T/C | V/V | 1000GP (CEU, CHBJPT) |
| 11 | 5,841,382 | 5,841,382 | SYN | T/C | G/G | 1000GP (CHBJPT) |
| 11 | 100 | -100 | NS | A/C | M/R | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | T/C | V/V | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,730,377 | 5,970,717 | CopyNumber | Variation_3836 (DGV) |
| 11 | 5,505,764 | 6,194,475 | CopyNumber | Variation_34458 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| G298E | A242T | L233R | Y228C | M203R | F174Y | I163V | W137R | R128C | G102R | S99P | T81M | C68F | Q59E | F52L | I43V | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | G | A | L | Y | M | F | I | W | R | G | S | T | C | Q | F | I | 48.46 | 1.000 |
| 2 | G | A | L | Y | R | F | V | R | R | G | P | T | F | Q | L | V | 32.26 | 1.000 |
| 3 | G | A | L | Y | M | F | I | R | R | G | S | T | C | Q | F | I | 8.29 | 1.000 |
| 4 | G | A | L | Y | M | F | V | W | R | G | P | T | F | Q | L | V | 4.07 | 1.000 |
| 5 | G | T | L | Y | R | F | V | R | R | G | P | T | F | Q | L | V | 1.00 | 1.000 |
| 6 | G | A | L | Y | M | Y | V | W | R | G | P | T | F | Q | L | V | 0.84 | 1.000 |
| 7 | E | A | L | Y | M | F | I | W | R | G | S | T | C | Q | F | I | 0.69 | 1.000 |
| 8 | G | A | L | Y | R | F | V | W | R | G | P | T | F | Q | L | V | 0.54 | 1.000 |
| 9 | G | A | L | Y | M | F | V | W | C | G | P | T | F | E | L | V | 0.54 | 1.000 |
| 10 | G | A | R | Y | M | F | V | W | R | G | P | T | F | Q | L | V | 0.38 | 1.000 |
| 11 | G | A | L | Y | M | F | I | W | R | R | S | T | C | Q | F | I | 0.38 | 1.000 |
| 12 | G | A | L | Y | R | F | V | R | R | G | P | T | F | Q | F | I | 0.23 | 1.000 |
| 13 | G | A | L | Y | R | F | I | W | R | G | P | T | F | Q | L | V | 0.23 | 1.000 |
| 14 | G | A | L | Y | M | F | V | R | R | G | P | T | F | Q | L | V | 0.23 | 1.000 |
| 15 | G | A | L | Y | M | F | V | W | R | G | P | T | F | Q | L | I | 0.15 | 1.000 |
| 16 | G | A | L | Y | R | F | I | W | R | G | S | T | C | Q | F | I | 0.15 | 1.000 |
| 17 | G | A | L | C | M | F | V | W | R | G | P | T | F | Q | L | V | 0.15 | 1.000 |
| 18 | G | A | L | C | R | F | V | R | R | G | P | T | F | Q | L | V | 0.15 | 1.000 |
| 19 | G | A | L | Y | M | F | V | R | C | G | P | T | F | E | L | V | 0.15 | 1.000 |
| 20 | G | A | L | Y | M | F | V | R | R | G | S | T | C | Q | F | I | 0.08 | 1.000 |
| 21 | G | A | L | Y | M | F | V | R | R | G | S | T | F | E | L | V | 0.08 | 1.000 |
| 22 | G | A | R | Y | M | F | V | W | R | G | S | T | F | Q | F | I | 0.08 | 1.000 |
| 23 | G | A | L | Y | M | F | V | W | R | G | S | T | F | Q | F | V | 0.08 | 1.000 |
| 24 | G | A | L | Y | M | F | I | W | R | G | S | T | F | Q | F | I | 0.08 | 1.000 |
| 25 | G | A | L | Y | R | F | I | R | R | G | S | T | C | Q | F | I | 0.08 | 1.000 |
| 26 | G | A | L | Y | R | F | V | R | R | G | P | T | C | Q | L | V | 0.08 | 1.000 |
| 27 | G | A | L | Y | M | Y | V | R | R | G | P | T | F | Q | L | V | 0.08 | 1.000 |
| 28 | G | A | L | Y | M | F | I | R | R | G | S | M | C | Q | F | I | 0.08 | 1.000 |
| 29 | G | A | R | Y | M | F | V | W | R | G | P | T | F | Q | F | I | 0.08 | 1.000 |
| 30 | G | A | L | Y | R | F | I | R | R | G | P | T | F | Q | L | V | 0.08 | 1.000 |
| 31 | G | A | R | Y | M | F | V | W | R | G | S | T | F | Q | F | V | 0.08 | 1.000 |
| 32 | G | A | L | Y | M | F | I | W | C | G | S | T | C | Q | F | I | 0.08 | 1.000 |
| 33 | G | A | L | Y | M | F | I | W | R | G | S | M | C | Q | F | I | 0.08 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52E6.aApr07-unspliced | main_exon | 3UTR | chr11 | 5,840,928 | 5,840,959 | - |
| CDS | chr11 | 5,840,959 | 5,841,897 | - | ||