OR5B12 Olfactory Receptor
| Gene Symbol | OR5B121 (View this gene in GeneCards) |
| Family | 5 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.25 (functional) |
| Aliases | OR11-241, HsOR11.12.22 |
| External Ids | HGNC: 15432 GeneBank: AB065851, AF399637, BK004507, NM_001004733 |
| Build #39 labels | OR5B12P, OR5B16 |
| Chromosomal location | 11:58,439,210-58,440,151 (-) |
| Cluster | 11@58 |
| Synteny | CLIC#27 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR5B1P | 71.29% | 310 |
| OR5B2 | 73.29% | 307 |
| OR5B3 | 74.36% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR5B2B | 76% | 312 |
| Mouse | Or5b12 | 81% | 314 |
| Mouse | Or5b12b | 81% | 314 |
| Rat | Or5b12 | 81% | 313 |
| Cow | OR5B12C | 83% | 314 |
| Orang | OR5B12P | 90% | 314 |
| Horse | OR5B12D | 87% | 314 |
| Chimp | OR5B12P | 97% | 315 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136947 |
| GNF Atlas2 | gnf1h02108_at |
Sequence information
| Nucleotide sequence |
ATGGAGAACAACACAGAGGTGACTGAATTCATCCTTGTGGGGTTAACTGATGACCCAGAA CTGCAGATCCCACTCTTCATAGTCTTCCTTTTCATCTACCTCATCACTCTGGTTGGGAAC CTGGGGATGATTGAATTGATTCTACTGGACTCCTGTCTCCACACCCCCATGTACTTCTTC CTCAGTAACCTCTCCCTGGTGGACTTTGGTTATTCCTCAGCTGTCACTCCCAAGGTGATG GTGGGGTTTCTCACAGGAGACAAATTCATATTATATAATGCTTGTGCCACACAATTCTTC TTCTTTGTAGCCTTTATCACTGCAGAAAGTTTCCTCCTGGCATCAATGGCCTATGACCGC TATGCAGCATTGTGTAAACCCCTGCATTACACCACCACCATGACAACAAATGTATGTGCT TGCCTGGCCATAGGCTCCTACATCTGTGGTTTCCTGAATGCATCCATTCATACTGGGAAC ACTTTCAGGCTCTCCTTCTGTAGATCCAATGTAGTTGAACACTTTTTCTGTGATGCTCCT CCTCTCTTGACTCTCTCATGTTCAGACAACTACATCAGTGAGATGGTTATTTTTTTTGTG GTGGGATTCAATGACCTCTTTTCTATCCTGGTAATCTTGATCTCCTACTTATTTATATTT ATCACCATCATGAAGATGCGCTCACCTGAAGGACGCCAGAAGGCCTTTTCTACTTGTGCT TCCCACCTTACTGCAGTTTCCATCTTTTATGGGACAGGAATCTTTATGTACTTACGACCT AACTCCAGCCATTTCATGGGCACAGACAAAATGGCATCTGTGTTCTATGCCATAGTCATT CCCATGTTGAATCCACTGGTCTACAGCCTGAGGAACAAAGAGGTTAAGAGTGCCTTTAAA AAGACTGTAGGGAAGGCAAAGGCCTCTATAGGATTCATATTT |
| Conceptual translation |
MENNTEVTEFILVGLTDDPELQIPLFIVFLFIYLITLVGNLGMIELILLDSCLHTPMYFF LSNLSLVDFGYSSAVTPKVMVGFLTGDKFILYNACATQFFFFVAFITAESFLLASMAYDR YAALCKPLHYTTTMTTNVCACLAIGSYICGFLNASIHTGNTFRLSFCRSNVVEHFFCDAP PLLTLSCSDNYISEMVIFFVVGFNDLFSILVILISYLFIFITIMKMRSPEGRQKAFSTCA SHLTAVSIFYGTGIFMYLRPNSSHFMGTDKMASVFYAIVIPMLNPLVYSLRNKEVKSAFK KTVGKAKASIGFIF Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 58,207,429 | 58,207,428 | Ins(1) | -/G | rs34206261 (DbSNP) | |
| 11 | 58,207,204 | 58,207,204 | NS | A/G | C/R | rs4938895 (DbSNP) |
| 11 | 58,207,203 | 58,207,203 | NS | C/T | C/Y | rs11229457 (DbSNP) |
| 11 | 58,207,567 | 58,207,567 | NS | C/T | E/K | rs11229458 (DbSNP) |
| 11 | 58,439,241 | 58,439,241 | NS | C/T | G/E | 1000GP (CEU) |
| 11 | 58,439,731 | 58,439,731 | NS | A/G | C/R | 1000GP (CEU, CHBJPT) |
| 11 | 58,439,230 | 58,439,230 | NS | C/T | A/T | 1000GP (CEU) |
| 11 | 58,440,137 | 58,440,137 | SYN | T/A | T/T | 1000GP (CEU) |
| 11 | 58,439,730 | 58,439,730 | NS | C/T | C/Y | 1000GP (CEU, CHBJPT) |
| 11 | 100 | -100 | NS | C/T | C/Y | 1000GP (YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 205 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| A308T | G304E | R259* | C141Y | C141R | D87E | I44T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | A | G | R | C | R | D | I | 76.27 | 0.384 |
| 2 | A | G | R | Y | R | D | I | 21.20 | 0.384 |
| 3 | T | G | R | C | R | D | I | 0.69 | 0.384 |
| 4 | A | E | R | C | R | D | I | 0.69 | 0.384 |
| 5 | A | G | R | C | R | E | I | 0.46 | 0.384 |
| 6 | A | G | R | C | R | D | T | 0.46 | 0.384 |
| 7 | A | G | * | C | R | D | I | 0.15 | 1.200 |
| 8 | A | G | R | C | C | D | I | 0.08 | 0.384 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR5B12.aApr07-unspliced | main_exon | 3UTR | chr11 | 58,439,207 | 58,439,210 | - |
| CDS | chr11 | 58,439,210 | 58,440,151 | - | ||