OR6C3 Olfactory Receptor
| Gene Symbol | OR6C31 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | 0.08 (functional) |
| Aliases | HSA8, HsOR12.5.12, ORL3819 |
| External Ids | HGNC: 15437 GeneBank: AF179770, NM_054104 ORDB: ORL3819 |
| Build #39 labels | OR6C3 |
| Chromosomal location | 12:55,331,701-55,332,633 (+) |
| Cluster | 12@56 |
| Synteny | CLIC#31 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6C1 | 74.76% | 309 |
| OR6C5P | 78.39% | 310 |
| OR6C7P | 80.39% | 311 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6C3I | 90% | 311 |
| Mouse | Or6c3 | 88% | 311 |
| Rat | Or6c3d | 89% | 311 |
| Rat | Or6c3 | 89% | 311 |
| Rat | Or6c3c | 89% | 311 |
| Cow | OR6C3J | 93% | 311 |
| Cow | OR6C3KP | 90% | 311 |
| Cow | OR6C3LP | 90% | 309 |
| Orang | OR6C7P | 82% | 310 |
| Horse | OR6C7 | 85% | 310 |
| Horse | OR6C7K | 84% | 310 |
| Chimp | OR6C1 | 74% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | AB463979 |
Sequence information
| Nucleotide sequence |
ATGAACCACACAATGGTCACAGAGTTTGTCCTCCTGGGCCTTTCTGATGATCCTGACCTT CAGATTGTGATTTTTCTCTTTTTATTTATCACGTATATATTAAGTGTTACTGGAAACCTG ACTATCATCACCCTAACCTTTGTGGACTCCCATCTGCAGACACCTATGTATTTCTTCCTC CGGAACTTCTCTTTCTTAGAAATCTCATTTACAACCGTATGCATCCCCAGATTTCTGGGG GCAATTATCACCAGGAATAAGACTATTTCCTATAACAACTGTGCAGCCCAACTCTTTTTC TTTATCTTCATGGGGGTGACTGAATTTTACATTTTAACTGCCATGTCCTATGACCGCTAT GTTGCCATCTGCAAGCCCCTTCATTACACATCCATCATGAACAGGAAACTCTGCACTCTA CTTGTGCTGTGTGCCTGGCTAAGTGGGTTTCTGACCATTTTCCCACCCCTTATGCTTCTC CTCCAGCTGGATTACTGTGCTTCCAACGTCATTGATCACTTTGCATGTGACTATTTTCCC CTCTTACAACTATCTTGTTCAGATACATGGCTCCTAGAAGTAATTGGTTTTTACTTTGCT TTGGTTACTTTGCTGTTCACTTTGGCATTAGTGATTTTATCTTACATGTACATTATCAGG ACCATTTTGAGAATCCCGTCTGCCAGTCAAAGAAAAAAGGCTTTCTCCACTTGTTCTTCT CACATGATTGTCATTTCCATTTCTTATGGAAGCTGTATATTCATGTATGCTAATCCATCT GCAAAAGAAAAGGCATCATTGACAAAAGGAATAGCTATTCTCAATACATCTGTTGCCCCC ATGCTGAACCCCTTCATTTACACTCTGAGAAACCAGCAAGTAAAACAAGCCTTCAAAAAT GTGGTCCACAAAGTTGTGTTTTATGCAAATCAA |
| Conceptual translation |
MNHTMVTEFVLLGLSDDPDLQIVIFLFLFITYILSVTGNLTIITLTFVDSHLQTPMYFFL RNFSFLEISFTTVCIPRFLGAIITRNKTISYNNCAAQLFFFIFMGVTEFYILTAMSYDRY VAICKPLHYTSIMNRKLCTLLVLCAWLSGFLTIFPPLMLLLQLDYCASNVIDHFACDYFP LLQLSCSDTWLLEVIGFYFALVTLLFTLALVILSYMYIIRTILRIPSASQRKKAFSTCSS HMIVISISYGSCIFMYANPSAKEKASLTKGIAILNTSVAPMLNPFIYTLRNQQVKQAFKN VVHKVVFYANQ Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 12 | 100 | -100 | NS | C/T | S/L | 1000GP (YRI, YRI, YRI, YRI) |
| 12 | 100 | -100 | SYN | C/A | T/T | 1000GP (YRI) |
| 12 | 55,331,906 | 55,331,906 | NS | C/T | S/L | 1000GP (CEU) |
| 12 | 55,331,962 | 55,331,962 | NS | A/T | T/S | 1000GP (CHBJPT) |
| 12 | 55,332,190 | 55,332,190 | NS | G/C | D/H | 1000GP (CEU) |
| 12 | 55,725,690 | 55,725,690 | NS | T/C | L/S | rs4318060 (DbSNP) |
| 12 | 55,725,882 | 55,725,882 | NS | C/T | T/M | rs11835321 (DbSNP) |
| 12 | 55,725,974 | 55,725,974 | NS | G/T | D/Y | rs73324778 (DbSNP) |
| 12 | 55,726,184 | 55,726,184 | NS | G/T | A/S | rs11832940 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 12 | 55,714,876 | 55,725,690 | CopyNumber | Variation_1912 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| Q53K | S69L | T88S | M133T | S148T | V194I | I219F | A234S | A297T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Q | S | T | M | S | V | I | A | A | 78.65 | 0.212 |
| 2 | Q | L | T | M | S | V | I | A | A | 13.44 | 0.212 |
| 3 | Q | S | T | T | S | V | I | A | A | 3.76 | 0.275 |
| 4 | Q | S | S | M | S | V | I | A | A | 2.07 | 0.212 |
| 5 | Q | S | T | T | S | V | I | S | A | 1.08 | 0.521 |
| 6 | Q | S | T | T | S | V | F | A | A | 0.46 | 0.275 |
| 7 | Q | S | T | M | S | I | I | A | A | 0.23 | 0.212 |
| 8 | Q | S | T | M | S | V | I | A | T | 0.15 | 0.212 |
| 9 | Q | S | T | M | T | V | I | A | A | 0.08 | 0.212 |
| 10 | K | S | T | M | S | V | I | A | A | 0.08 | 0.212 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6C3.aApr07-unspliced | main_exon | CDS | chr12 | 55,331,701 | 55,332,633 | + |
| 3UTR | chr12 | 55,332,633 | 55,332,636 | + | ||