OR8B8 Olfactory Receptor
| Gene Symbol | OR8B8 (View this gene in GeneCards) |
| Family | 8 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.03 (functional) |
| Aliases | OR11-316, HSTPCR85, JCG8, HsOR11.18.36, ORL3422 |
| GeneBank Accessions | AB065832, AF238488, AF399510, BK004496, HSTPCR85P, NM_012378 |
| ORDB | ORL3422 |
| Build #39 labels | OR8B8 |
| Chromosomal location | 11:124,310,049-124,310,981 (-) |
| Cluster | 11@124 |
| Synteny | CLIC#29 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR8B10P | 72.67% | 311 |
| OR8B12 | 80.06% | 311 |
| OR8B9P | 76.24% | 303 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | cOR8B8 | 89% | 285 |
| Chimp | CONTIG497.53-36780 | 98% | 311 |
| Mouse | MOR161-6 | 86% | 311 |
| Rat | NM_001000818 | 86% | 311 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | X89675 |
| GNF Atlas2 | gnf1h02117_at |
Sequence information
| Nucleotide sequence |
ATGGCTGCTGAGAATTCCTCCTTCGTGACACAGTTTATCCTCGCAGGCTTAACTGACCAA CCGGGAGTCCAGATCCCCCTCTTCTTCCTGTTTCTAGGCTTCTACGTGGTCACTGTGGTG GGGAACCTGGGCTTGATAACCCTGATAAGGCTCAACTCTCACTTGCACACCCCTATGTAC TTCTTCCTCTATAACTTGTCCTTCATAGATTTCTGCTATTCCAGTGTTATCACTCCCAAA ATGCTGATGAGCTTTGTCTTAAAGAAGAACAGCATCTCCTACGCAGGGTGTATGACTCAG CTCTTCTTCTTTCTTTTCTTTGTTGTCTCTGAGTCCTTCATCCTGTCAGCAATGGCGTAT GACCGCTATGTGGCCATCTGTAACCCACTGTTGTACATGGTCACCATGTCTCCCCAGGTG TGTTTTCTCCTTTTGTTGGGTGTCTATGGGATGGGGTTTGCTGGGGCCATGGCCCACACA GCGTGCATGATGGGTGTGACCTTCTGTGCCAATAACCTTGTCAACCACTACATGTGTGAC ATCCTTCCCCTTCTTGAGTGTGCTTGCACCAGCACCTATGTGAATGAGCTTGTAGTGTTT GTTGTTGTGGGCATTGATATTGGTGTGCCCACAGTCACCATCTTCATTTCCTATGCTCTC ATTCTCTCCAGCATCTTCCACATTGATTCCACGGAGGGCAGGTCCAAAGCCTTCAGCACC TGCAGCTCCCACATAATTGCAGTTTCTCTGTTCTTTGGGTCAGGAGCATTCATGTACCTC AAACCCTTTTCTCTTTTAGCTATGAACCAGGGCAAGGTGTCTTCCCTATTCTATACCACT GTGGTGCCCATGCTCAACCCATTAATTTATAGCCTGAGGAATAAGGACGTCAAAGTTGCT CTAAAGAAAATCTTGAACAAAAATGCATTCTCC |
| Conceptual translation |
MAAENSSFVTQFILAGLTDQPGVQIPLFFLFLGFYVVTVVGNLGLITLIRLNSHLHTPMY FFLYNLSFIDFCYSSVITPKMLMSFVLKKNSISYAGCMTQLFFFLFFVVSESFILSAMAY DRYVAICNPLLYMVTMSPQVCFLLLLGVYGMGFAGAMAHTACMMGVTFCANNLVNHYMCD ILPLLECACTSTYVNELVVFVVVGIDIGVPTVTIFISYALILSSIFHIDSTEGRSKAFST CSSHIIAVSLFFGSGAFMYLKPFSLLAMNQGKVSSLFYTTVVPMLNPLIYSLRNKDVKVA LKKILNKNAFS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 124,310,070 | 124,310,070 | SYN | G/A | I/I | 1000GP (CHBJPT) |
| 11 | 124,310,273 | 124,310,273 | NS | C/T | A/T | 1000GP (CEU) |
| 11 | 124,310,318 | 124,310,318 | NS | A/G | F/L | rs1893135 (DbSNP) |
| 11 | 124,310,406 | 124,310,406 | SYN | A/G | T/T | rs11606970 (DbSNP) |
| 11 | 124,310,499 | 124,310,499 | SYN | C/G | A/A | 1000GP (CEU, YRI) |
| 11 | 124,310,618 | 124,310,618 | NS | G/A | R/C | rs61733267 (DbSNP) |
| 11 | 124,310,622 | 124,310,622 | SYN | A/G | Y/Y | rs4296049 (DbSNP), 1000GP (CEU, CHBJPT) |
| 11 | 124,310,692 | 124,310,692 | NS | C/T | C/Y | rs61912424 (DbSNP) |
| 11 | 124,310,752 | 124,310,752 | NS | A/T | I/N | rs72472248 (DbSNP), 1000GP (CHBJPT) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 124,308,049 | 124,311,081 | Deletion | #234 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| S291I | F238I | L222F | R122C | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | S | F | L | R | 99.00 | 0.140 |
| 2 | S | F | L | C | 0.38 | 0.743 |
| 3 | S | F | F | R | 0.38 | 0.140 |
| 4 | I | F | L | R | 0.15 | 0.140 |
| 5 | S | I | L | R | 0.08 | 0.229 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR8B8.aApr07-unspliced | main_exon | 3UTR | chr11 | 124,310,022 | 124,310,049 | - |
| CDS | chr11 | 124,310,049 | 124,310,981 | - | ||
| 5UTR | chr11 | 124,310,981 | 124,311,054 | - | ||