OR8D2 Olfactory Receptor
| Gene Symbol | OR8D21 (View this gene in GeneCards) |
| Family | 8 |
| Subfamily | D |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | AC002556-E, JCG2, OR11-303, HsOR11.18.27, ORL1026 |
| External Ids | HGNC: 8482 GeneBank: AF162668, AF162669, BK004202, NM_001002918 ORDB: ORL1026 |
| Build #39 labels | OR8D2 |
| Chromosomal location | 11:124,319,265-124,320,197 (-) |
| Cluster | 11@124 |
| Synteny | CLIC#29 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs2512219) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR8A1 | 65.26% | 308 |
| OR8D1 | 70.13% | 308 |
| OR8G2P | 64.36% | 303 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR8G3 | 64% | 311 |
| Mouse | Or8d2 | 85% | 307 |
| Rat | Or8d2c-ps | 83% | 309 |
| Rat | Or8d2-ps | 83% | 309 |
| Cow | OR8D2P | 84% | 308 |
| Orang | OR8D1 | 69% | 308 |
| Horse | OR8D1 | 72% | 304 |
| Chimp | OR8D1 | 70% | 308 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | AF162668 |
| GNF Atlas2 | gnf1h05807_at |
Sequence information
| Nucleotide sequence |
ATGGCTACTTCAAACCATTCTTCAGGGGCTGAGTTTATCCTGGCAGGCTTGACACAACGC CCAGAACTTCAACTGCCACTCTTCCTCCTGTTCCTTGGAATATATGTGGTCACAGTGGTG GGGAACCTGGGCATGATCTTCTTAATTGCTCTCAGTTCTCAACTTTACCCTCCAGTGTAT TATTTTCTCAGTCATTTGTCTTTCATTGATCTCTGCTACTCCTCTGTCATTACCCCTAAG ATGCTGGTGAACTTTGTTCCAGAGGAGAACATTATCTCCTTTCTGGAATGCATTACTCAA CTTTATTTCTTCCTTATTTTTGTAATTGCAGAAGGCTACCTTCTGACAGCCATGGAATAT GACCGTTATGTTGCTATCTGTCGCCCACTGCTTTACAATATTGTCATGTCCCACAGGGTC TGTTCCATAATGATGGCTGTGGTATACTCACTGGGTTTTCTGTGGGCCACAGTCCATACT ACCCGCATGTCAGTGTTGTCATTCTGTAGGTCTCATACGGTCAGTCATTATTTTTGTGAT ATTCTCCCCTTATTGACTCTGTCTTGCTCCAGCACCCACATCAATGAGATTCTGCTGTTC ATTATTGGAGGAGTTAATACCTTAGCAACTACACTGGCGGTCCTTATCTCTTATGCTTTC ATTTTCTCTAGTATCCTTGGTATTCATTCCACTGAGGGGCAATCCAAAGCCTTTGGCACT TGTAGCTCCCATCTCTTGGCTGTGGGCATCTTTTTTGGGTCTATAACATTCATGTATTTC AAGCCCCCTTCCAGCACTACTATGGAAAAAGAGAAGGTGTCTTCTGTGTTCTACATCACA ATAATCCCCATGCTGAATCCTCTAATCTATAGCCTGAGGAACAAGGATGTGAAAAATGCA CTGAAGAAGATGACTAGGGGAAGGCAGTCATCC |
| Conceptual translation |
MATSNHSSGAEFILAGLTQRPELQLPLFLLFLGIYVVTVVGNLGMIFLIALSSQLYPPVY YFLSHLSFIDLCYSSVITPKMLVNFVPEENIISFLECITQLYFFLIFVIAEGYLLTAMEY DRYVAICRPLLYNIVMSHRVCSIMMAVVYSLGFLWATVHTTRMSVLSFCRSHTVSHYFCD ILPLLTLSCSSTHINEILLFIIGGVNTLATTLAVLISYAFIFSSILGIHSTEGQSKAFGT CSSHLLAVGIFFGSITFMYFKPPSSTTMEKEKVSSVFYITIIPMLNPLIYSLRNKDVKNA LKKMTRGRQSS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | NS | G/A | P/L | 1000GP (YRI, YRI, YRI) |
| 11 | 124,189,306 | 124,189,306 | NS | A/G | L/P | rs2466620 (DbSNP) |
| 11 | 124,189,729 | 124,189,729 | NS | T/C | H/R | rs2512219 (DbSNP) |
| 11 | 124,189,971 | 124,189,971 | SYN | C/T | G/G | rs7127554 (DbSNP) |
| 11 | 124,190,036 | 124,190,036 | NS | G/A | R/C | rs61735123 (DbSNP) |
| 11 | 124,319,396 | 124,319,396 | NS | T/C | M/V | 1000GP (CHBJPT) |
| 11 | 124,319,410 | 124,319,410 | NS | G/A | P/L | 1000GP (CEU, CHBJPT) |
| 11 | 124,319,833 | 124,319,833 | NS | C/T | R/H | 1000GP (CEU, CHBJPT) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| M268V | P263L | R122H | R20C | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | M | P | R | R | 74.81 | 0.758 |
| 2 | M | L | H | R | 20.74 | 0.982 |
| 3 | M | P | H | R | 1.92 | 0.982 |
| 4 | M | L | H | C | 1.54 | 0.982 |
| 5 | V | L | H | R | 0.54 | 0.982 |
| 6 | M | P | H | C | 0.31 | 0.982 |
| 7 | M | P | R | C | 0.08 | 0.758 |
| 8 | M | L | R | R | 0.08 | 0.758 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR8D2.aApr07-unspliced | main_exon | 3UTR | chr11 | 124,319,262 | 124,319,265 | - |
| CDS | chr11 | 124,319,265 | 124,320,197 | - | ||