OR8D4 Olfactory Receptor

Gene Symbol	OR8D4¹ (View this gene in GeneCards)
Family	8
Subfamily	D
Pseudogene	No
CORP pseudogene probability score	0.16 (functional)
Aliases	OR11-275, HsOR11.18.5, ORL3289
External Ids	HGNC: 14840 GeneBank: AB065761, BK004313, NM_001005197 ORDB: ORL3289
Build #39 labels	OR8D4
Chromosomal location	11:123,906,432-123,907,373 (+)
Cluster	11@124
Synteny	CLIC#29
Remarks

Most Similar ORs in Humans (Paralogs)

Symbol	Percent	Length
OR8A1	65.05%	309
OR8D1	65.25%	305
	60.45%	311

Most Similar ORs in other species (Orthologs)

Specie	Symbol	Percent	Length
Dog	OR8A1	66%	309
Mouse	Or8d4	85%	310
Rat	Or8d4	85%	310
Cow	OR8A1	66%	309
Orang	OR8D1	63%	308
Horse	OR8D4B	87%	310
Horse	OR8D4CP	86%	311
Chimp	OR8D1	65%	308

Expression evidences

Source	Accession
ESTs	AL706931
mRNA	BC137206
GNF Atlas2	gnf1h05555_at
GNF Atlas2	gnf1h05556_s_at

Sequence information

Nucleotide sequence

ATGGGTGTAAAAAACCATTCCACAGTGACTGAGTTTCTTCTTTCAGGATTAACTGAACAA
GCAGAGCTTCAGCTGCCCCTCTTCTGCCTCTTCTTAGGAATTTACACAGTTACTGTGGTG
GGAAACCTCAGCATGATCTCAATTATTAGGCTGAATCGTCAACTTCATACCCCCATGTAC
TATTTCCTGAGTAGTTTGTCTTTTTTAGATTTCTGCTATTCTTCTGTCATTACCCCTAAA
ATGCTATCAGGGTTTTTATGCAGAGATAGATCCATCTCCTATTCTGGATGCATGATTCAG
CTGTTTTTTTTCTGTGTTTGTGTTATTTCTGAATGCTACATGCTGGCAGCCATGGCCTGC
GATCGCTACGTGGCCATCTGCAGCCCACTGCTCTACAGGGTCATCATGTCCCCTAGGGTC
TGTTCTCTGCTGGTGGCTGCTGTCTTCTCAGTAGGTTTCACTGATGCTGTGATCCATGGA
GGTTGTATACTCAGGTTGTCTTTCTGTGGATCAAACATCATTAAACATTATTTCTGTGAC
ATTGTCCCTCTTATTAAACTCTCCTGCTCCAGCACTTATATTGATGAGCTTTTGATTTTT
GTCATTGGTGGATTTAACATGGTGGCCACAAGCCTAACAATCATTATTTCATATGCTTTT
ATCCTCACCAGCATCCTGCGCATCCACTCTAAAAAGGGCAGGTGCAAAGCGTTTAGCACC
TGTAGCTCCCACCTGACAGCTGTTCTTATGTTTTATGGGTCTCTGATGTCCATGTATCTC
AAACCTGCTTCTAGCAGTTCACTCACCCAGGAGAAAGTATCCTCAGTATTTTATACCACT
GTGATTCTCATGTTGAATCCCTTGATATATAGTCTGAGGAACAATGAAGTAAGAAATGCT
CTGATGAAACTTTTAAGAAGAAAAATATCTTTATCTCCAGGA

Conceptual translation

MGVKNHSTVTEFLLSGLTEQAELQLPLFCLFLGIYTVTVVGNLSMISIIRLNRQLHTPMY
YFLSSLSFLDFCYSSVITPKMLSGFLCRDRSISYSGCMIQLFFFCVCVISECYMLAAMAC
DRYVAICSPLLYRVIMSPRVCSLLVAAVFSVGFTDAVIHGGCILRLSFCGSNIIKHYFCD
IVPLIKLSCSSTYIDELLIFVIGGFNMVATSLTIIISYAFILTSILRIHSKKGRCKAFST
CSSHLTAVLMFYGSLMSMYLKPASSSSLTQEKVSSVFYTTVILMLNPLIYSLRNNEVRNA
LMKLLRRKISLSPG

Protein domains and features

Variations - SNPs

Chr	Start	End	Type	Variation	AA Change	SNP IDs
11	100	-100	NS	T/G	L/R	1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI)
11	100	-100	SYN	T/C	C/C	1000GP (YRI)
11	123,777,268	123,777,268	NS	A/C	S/R	rs61734934 (DbSNP)
11	123,777,289	123,777,289	SYN	C/T	L/L	rs57888441 (DbSNP)
11	123,777,302	123,777,302	NS	G/T	R/L	rs17127947 (DbSNP)
11	123,777,412	123,777,412	NS	A/G	I/V	rs17127950 (DbSNP)
11	123,777,497	123,777,497	NS	A/G	Y/C	rs10750250 (DbSNP)
11	123,777,498	123,777,498	SYN	C/T	C/C	rs10893102 (DbSNP)
11	123,777,502	123,777,502	NS	C/T	R/C	rs61907183 (DbSNP)
11	123,777,511	123,777,511	NS	G/T	A/S	rs61745074 (DbSNP)
11	123,777,536	123,777,536	NS	A/G	K/R	rs7926767 (DbSNP)
11	123,777,736	123,777,736	NS	C/T	L/F	rs10790610 (DbSNP)
11	123,777,752	123,777,752	NS	C/T	S/F	rs12270203 (DbSNP)
11	123,777,754	123,777,753	Ins(1)	-/C		rs35139196 (DbSNP)
11	123,777,754	123,777,754	NS	A/C	N/H	rs61744420 (DbSNP)
11	123,777,861	123,777,861	SYN	C/T	C/C	rs61748875 (DbSNP)
11	123,777,986	123,777,986	NS	C/T	P/L	rs7942047 (DbSNP)
11	123,778,031	123,778,031	NS	A/G	K/R	rs7927385 (DbSNP)
11	123,906,595	123,906,595	NS	T/G	L/R	1000GP (CEU, CHBJPT)
11	123,906,705	123,906,705	NS	A/G	I/V	1000GP (CEU, CHBJPT)
11	123,906,790	123,906,790	NS	G/A	C/Y	1000GP (CEU, CHBJPT)
11	123,906,791	123,906,791	SYN	C/T	C/C	1000GP (CEU, CHBJPT)
11	123,906,795	123,906,795	NS	C/T	R/C	1000GP (CEU)
11	123,906,829	123,906,829	NS	G/A	R/K	1000GP (CEU, CHBJPT)
11	123,906,839	123,906,839	NS	G/C	M/I	1000GP (CEU)
11	123,907,029	123,907,029	NS	T/C	F/L	1000GP (CEU, CHBJPT)
11	123,907,154	123,907,154	SYN	T/C	C/C	1000GP (CEU, CHBJPT)
11	123,907,279	123,907,279	NS	T/C	L/P	1000GP (CEU, CHBJPT)
11	123,907,324	123,907,324	NS	G/A	R/K	1000GP (CEU, CHBJPT)

Haplotypes

Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.

	T38S	S44R	I48V	L55R	I92V	A125S	R133K	M136I	F200L	N206H	S239N	L283P	R298K	% Freq	CORP
1	T	S	I	L	I	A	K	M	L	N	S	P	K	25.12	0.300
2	T	S	I	L	I	A	K	M	F	N	S	P	K	22.20	0.300
3	T	S	I	R	V	A	K	M	F	N	S	P	K	17.67	0.792
4	T	S	I	L	I	A	R	M	F	N	S	L	R	15.90	0.446
5	T	S	I	L	I	A	R	M	F	N	S	P	R	13.29	0.300
6	T	S	I	R	V	A	K	M	F	N	N	P	K	2.15	0.857
7	T	S	I	L	I	S	K	M	F	N	S	P	K	1.84	1.000
8	T	S	V	L	I	A	R	M	F	N	S	P	R	0.31	0.300
9	T	S	I	L	I	A	K	M	F	N	S	P	R	0.31	0.300
10	T	R	I	L	I	A	K	M	F	H	S	P	K	0.31	0.300
11	T	S	I	L	I	A	R	M	F	N	S	P	K	0.23	0.300
12	T	S	I	L	I	A	R	M	L	N	S	P	K	0.08	0.300
13	T	S	I	L	I	A	K	M	L	N	S	L	K	0.08	0.446
14	T	S	I	L	I	A	K	I	L	N	S	P	K	0.08	0.377
15	T	S	I	R	V	A	R	M	F	N	S	P	K	0.08	0.792
16	T	S	I	L	V	A	R	M	F	N	S	L	R	0.08	0.573
17	T	S	I	R	V	A	K	M	F	N	S	P	R	0.08	0.792
18	S	S	I	L	I	A	K	M	L	N	S	P	K	0.08	0.300
19	T	S	I	L	I	A	R	M	F	N	S	L	K	0.08	0.446
20	T	S	I	L	I	A	K	M	L	N	N	P	K	0.08	0.403

AceView Gene Models

The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.

Accession	Type		Chr	Start	End	Strand
OR8D4.aApr07-unspliced	main_exon	5UTR	chr11	123,906,146	123,906,432	+
		CDS	chr11	123,906,432	123,907,373	+
		3UTR	chr11	123,907,373	123,907,376	+

HORDE

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