OR10AD1 Olfactory Receptor
| Gene Symbol | OR10AD11 (View this gene in GeneCards) |
| Family | 10 |
| Subfamily | AD |
| Pseudogene | No |
| CORP pseudogene probability score | 0.61 (pseudogene) |
| Aliases | OR12-1, HsOR12.3.1 |
| External Ids | HGNC: 14819 GeneBank: AB065872, AF399474, BK004354, NM_001004134 |
| Build #39 labels | OR10AD1 |
| Chromosomal location | 12:48,202,342-48,203,292 (-) |
| Cluster | 12@49a |
| Synteny | CLIC#30 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR10A4 | 46.13% | 310 |
| OR2D3 | 43.28% | 305 |
| OR5V1 | 44.44% | 306 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR10AD1P | 86% | 311 |
| Dog | OR10AD1CP | 84% | 316 |
| Dog | OR10AD1B | 84% | 316 |
| Mouse | Or10ad1c | 80% | 310 |
| Mouse | Or10ad1-ps | 81% | 305 |
| Rat | Or10ad1-ps | 81% | 301 |
| Cow | OR10AD1P | 83% | 316 |
| Cow | OR10AD1DP | 83% | 316 |
| Cow | OR10AD1C | 82% | 315 |
| Orang | OR10AD1P | 91% | 317 |
| Horse | OR10AD1EP | 82% | 312 |
| Chimp | OR10AD1P | 93% | 315 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | DB338028 |
| mRNA | AB587540 |
| GNF Atlas2 | gnf1h07571_at |
Sequence information
| Nucleotide sequence |
ATGCTAAGGAATGGCAGCATAGTGACGGAATTTATCCTCGTGGGCTTTCAGCAGAGCTCC ACTTCCACACGAGCATTGCTCTTTGCCCTCTTCTTGGCCCTCTACAGCCTCACCATGGCC ATGAATGGCCTCATCATCTTTATCACCTCCTGGACAGACCCCAAGCTCAACAGCCCCATG TACTTCTTCCTCGGCCATCTGTCTCTCCTGGATGTCTGCTTCATCACCACTACCATCCCA CAGATGTTGATCCACCTCGTGGTCAGGGACCACATTGTCTCCTTTGTATGTTGCATGACC CAGATGTACTTTGTCTTCTGTGTTGGTGTGGCCGAGTGCATCCTCTTGGCTTTCATGGCC TATGACCGTTATGTTGCTATCTGCTACCCACTTAACTATGTCCCGATCATAAGCCAGAAG GTCTGTGTCAGGCTTGTGGGAACTGCCTGGTTCTTTGGGCTGATCAATGGCATCTTTCTC GAGTATATTTCATTCCGAGAGCCCTTCCGCAGAGACAACCACATAGAAAGCTTCTTCTGT GAGGCCCCCATAGTGATTGGCCTCTCTTGTGGGGACCCTCAGTTTAGTCTGTGGGCAATC TTTGCCGATGCCATCGTGGTAATTCTCAGCCCCATGGTGCTCACTGTCACTTCCTATGTG CACATCCTGGCCACCATCCTCAGCAAAGCCTCCTCCTCAGGTCGGGGGAAGACTTTCTCT ACTTGTGCCTCTCACCTGACTGTGGTCATCTTTCTCTACACTTCAGCTATGTTCTCTTAC ATGAACCCCCACAGCACACATGGGCCTGACAAAGACAAACCTTTCTCCCTCCTGTACACC ATCATTACCCCCATGTGCAACCCCATCATTTATAGTTTCCGCAACAAGGAAATTAAGGAG GCCATGGTGAGGGCACTTGGAAGAACCAGGCTGGCCCAGCCACAGTCTGTC |
| Conceptual translation |
MLRNGSIVTEFILVGFQQSSTSTRALLFALFLALYSLTMAMNGLIIFITSWTDPKLNSPM YFFLGHLSLLDVCFITTTIPQMLIHLVVRDHIVSFVCCMTQMYFVFCVGVAECILLAFMA YDRYVAICYPLNYVPIISQKVCVRLVGTAWFFGLINGIFLEYISFREPFRRDNHIESFFC EAPIVIGLSCGDPQFSLWAIFADAIVVILSPMVLTVTSYVHILATILSKASSSGRGKTFS TCASHLTVVIFLYTSAMFSYMNPHSTHGPDKDKPFSLLYTIITPMCNPIIYSFRNKEIKE AMVRALGRTRLAQPQSV Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 12 | 48,596,877 | 48,596,876 | Ins(1) | -/A | rs58864350 (DbSNP) | |
| 12 | 48,596,878 | 48,596,877 | Ins(1) | -/A | rs67974295 (DbSNP) | |
| 12 | 48,597,053 | 48,597,053 | NS | A/G | V/A | rs17122812 (DbSNP) |
| 12 | 48,596,241 | 48,596,241 | NS | A/G | Y/H | rs11168459 (DbSNP) |
| 12 | 48,596,772 | 48,596,772 | NS | A/T | L/M | rs12818189 (DbSNP) |
| 12 | 48,596,771 | 48,596,771 | NS | A/T | M/K | rs12816566 (DbSNP) |
| 12 | 48,596,579 | 48,596,579 | NS | C/T | R/Q | rs17224674 (DbSNP) |
| 12 | 48,596,254 | 48,596,254 | SYN | A/C | P/P | rs11830378 (DbSNP) |
| 12 | 48,596,890 | 48,596,890 | SYN | A/G | F/F | rs17823193 (DbSNP) |
| 12 | 48,597,064 | 48,597,064 | SYN | A/G | N/N | rs17224828 (DbSNP) |
| 12 | 48,597,049 | 48,597,049 | SYN | C/T | T/T | rs17122809 (DbSNP) |
| 12 | 48,203,270 | 48,203,270 | NS | A/G | V/A | 1000GP (CEU, CHBJPT) |
| 12 | 48,203,107 | 48,203,107 | SYN | G/A | F/F | 1000GP (CEU) |
| 12 | 48,202,458 | 48,202,458 | NS | A/G | Y/H | 1000GP (CEU, CHBJPT) |
| 12 | 48,202,858 | 48,202,858 | SYN | A/G | L/L | 1000GP (CEU) |
| 12 | 48,203,281 | 48,203,281 | SYN | A/G | N/N | 1000GP (CEU) |
| 12 | 48,202,763 | 48,202,763 | NS | C/T | S/N | 1000GP (CEU) |
| 12 | 48,202,471 | 48,202,471 | SYN | A/C | P/P | 1000GP (CEU) |
| 12 | 48,202,589 | 48,202,589 | NS | C/T | R/Q | 1000GP (CEU) |
| 12 | 48,202,796 | 48,202,796 | NS | C/T | R/Q | 1000GP (CEU) |
| 12 | 48,202,701 | 48,202,701 | NS | A/T | W/R | 1000GP (CEU) |
| 12 | 48,203,266 | 48,203,266 | SYN | C/T | T/T | 1000GP (CEU) |
| 12 | 100 | -100 | NS | A/G | Y/H | 1000GP (YRI, YRI, YRI) |
| 12 | 100 | -100 | SYN | C/T | T/T | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 12 | 48,547,128 | 48,779,562 | CopyNumber | Variation_2983 (DGV) |
| 12 | 48,429,702 | 48,825,499 | CopyNumber | Variation_3888 (DGV) |
| 12 | 48,565,643 | 48,645,561 | CopyNumber | Variation_6987 (DGV) |
| 12 | 48,541,757 | 48,779,562 | CopyNumber | Variation_8729 (DGV) |
| 12 | 48,537,505 | 48,758,024 | CopyNumber | Variation_30600 (DGV) |
| CopyNumber | 105 (Hasin) | |||
| 12 | 48,594,125 | 48,597,175 | CopyNumber | #85 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| Y279H | W198R | S177N | R170C | R166Q | R123H | F104S | V8A | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Y | W | S | R | R | R | F | V | 72.58 | 0.654 |
| 2 | H | W | S | R | R | R | F | A | 16.67 | 0.654 |
| 3 | Y | R | N | R | Q | R | F | V | 3.38 | 0.654 |
| 4 | H | W | S | R | R | R | F | V | 2.53 | 0.654 |
| 5 | H | W | S | R | R | H | F | V | 2.38 | 0.971 |
| 6 | Y | R | N | R | R | R | F | V | 1.61 | 0.654 |
| 7 | Y | W | S | R | R | R | S | V | 0.54 | 0.654 |
| 8 | Y | W | S | C | R | R | F | V | 0.15 | 0.654 |
| 9 | H | W | S | C | R | R | F | V | 0.15 | 0.654 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR10AD1.aApr07 | main_exon | 3UTR | chr12 | 48,202,027 | 48,202,342 | - |
| CDS_partial | chr12 | 48,202,342 | 48,202,549 | - | ||
| exon_5UTR | chr12 | 48,233,569 | 48,233,776 | - | ||
| exon_5UTR | chr12 | 48,278,427 | 48,278,634 | - | ||
| exon_5UTR | chr12 | 48,284,150 | 48,284,209 | - | ||
| OR10AD1.bApr07-unspliced | main_exon | 3UTR | chr12 | 48,202,083 | 48,202,342 | - |
| CDS | chr12 | 48,202,342 | 48,203,292 | - | ||
| 5UTR | chr12 | 48,203,292 | 48,203,459 | - | ||