OR10H2 Olfactory Receptor
| Gene Symbol | OR10H21 (View this gene in GeneCards) |
| Family | 10 |
| Subfamily | H |
| Pseudogene | No |
| CORP pseudogene probability score | 0.09 (functional) |
| Aliases | OR19-23, AC004597-A, HsOR19.4.1, ORL312, ORL528 |
| External Ids | HGNC: 8173 GeneBank: AF399585, BC069085, BC069457, BK004211, NM_013939 ORDB: ORL312, ORL528 |
| Build #39 labels | OR10H2 |
| Chromosomal location | 19:15,728,044-15,728,988 (+) |
| Cluster | 19@16a |
| Synteny | CLIC#46 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR10H1 | 89.58% | 307 |
| OR10H5 | 88.42% | 311 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR10H1E | 83% | 315 |
| Dog | OR10H5B | 83% | 315 |
| Mouse | Or10h1 | 85% | 311 |
| Mouse | Or10h1b | 84% | 311 |
| Rat | Or10h1d | 85% | 310 |
| Rat | Or10h1c | 84% | 310 |
| Rat | Or10h1 | 85% | 303 |
| Cow | OR10H1 | 84% | 311 |
| Cow | OR10H1I | 83% | 310 |
| Cow | OR10H1F | 82% | 311 |
| Orang | OR10H5 | 89% | 311 |
| Orang | OR10H1 | 89% | 311 |
| Orang | OR10H1JP | 89% | 237 |
| Horse | OR10H1 | 77% | 311 |
| Chimp | OR10H3 | 73% | 307 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BG197640 |
| mRNA | BC069457 |
| GNF Atlas2 | 208543_at |
Sequence information
| Nucleotide sequence |
ATGCTGGGGCTAAACCACACCTCCATGTCTGAATTCATCCTCGTCGGCTTCTCTGCCTTC CCCCACCTCCAACTGATGCTCTTCCTGCTGTTCCTGCTGATGTACCTGTTCACGCTGCTG GGCAACCTGCTCATCATGGCCACCGTCTGGAGCGAGCGCAGCCTCCACACGCCCATGTAC CTCTTCCTGTGCGTCCTCTCAGTCTCCGAGATCCTCTACACCGTGGCCATCATCCCGCGC ATGCTGGCCGACCTGCTGTCCACCCAGCGCTCCATCGCCTTCCTGGCCTGTGCCAGTCAG ATGTTCTTCTCCTTCAGCTTCGGCTTCACCCACTCCTTCCTGCTCACCGTCATGGGCTAC GACCGCTACGTGGCCATCTGCCACCCCCTGCGCTACAACGTGCTCATGAGCCCACGGGGC TGCGCCTGCCTGGTGGGCTGCTCCTGGGCTGGTGGCTCGGTCATGGGGATGGTGGTGACC TCGGCCATTTTCCAACTGACTTTCTGTGGATCCCATGAGATCCAGCATTTTTTATGTCAT GTGCCACCTCTGTTGAAGTTGGCCTGTGGAAATAATGTACCAGCTGTGGCCCTGGGCGTG GGCTTGGTATGTATCATGGCACTGCTGGGCTGTTTTCTCCTCATCCTCCTCTCCTATGCC TTCATCGTGGCCGACATCTTGAAGATCCCTTCTGCTGAAGGTCGGAACAAGGCCTTCTCC ACCTGTGCCTCTCACCTTATTGTGGTCATTGTGCACTATGGCTTTGCCTCTGTCATCTAC CTCAAGCCCAAAGGTCCCCACTCTCAGGAGGGTGACACCCTGATGGCCACCACCTACGCA GTCCTCACGCCCTTCCTCAGCCCCATCATCTTCAGCCTCAGGAACAAAGAACTGAAGGTT GCCATGAAGAGGACCTTCCTCAGCACACTCTATTCCTCAGGCACC |
| Conceptual translation |
MLGLNHTSMSEFILVGFSAFPHLQLMLFLLFLLMYLFTLLGNLLIMATVWSERSLHTPMY LFLCVLSVSEILYTVAIIPRMLADLLSTQRSIAFLACASQMFFSFSFGFTHSFLLTVMGY DRYVAICHPLRYNVLMSPRGCACLVGCSWAGGSVMGMVVTSAIFQLTFCGSHEIQHFLCH VPPLLKLACGNNVPAVALGVGLVCIMALLGCFLLILLSYAFIVADILKIPSAEGRNKAFS TCASHLIVVIVHYGFASVIYLKPKGPHSQEGDTLMATTYAVLTPFLSPIIFSLRNKELKV AMKRTFLSTLYSSGT Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 19 | 100 | -100 | NS | A/G | I/V | 1000GP (YRI) |
| 19 | 100 | -100 | SYN | G/A | L/L | 1000GP (YRI, YRI) |
| 19 | 15,728,555 | 15,728,555 | NS | C/T | S/F | 1000GP (CEU, CHBJPT) |
| 19 | 15,728,649 | 15,728,649 | SYN | G/A | L/L | 1000GP (CEU, CHBJPT) |
| 19 | 15,838,858 | 15,838,857 | Ins(1) | -/G | rs34844969 (DbSNP) | |
| 19 | 15,838,925 | 15,838,925 | SYN | A/G | Q/Q | rs61733112 (DbSNP) |
| 19 | 15,838,967 | 15,838,967 | SYN | A/G | T/T | rs2285955 (DbSNP) |
| 19 | 15,838,972 | 15,838,972 | NS | A/T | Q/L | rs4569397 (DbSNP) |
| 19 | 15,839,081 | 15,839,081 | SYN | T/C | A/A | rs2067083 (DbSNP) |
| 19 | 15,839,168 | 15,839,168 | SYN | T/C | F/F | rs2003905 (DbSNP) |
| 19 | 15,839,174 | 15,839,174 | SYN | C/T | F/F | rs2285956 (DbSNP) |
| 19 | 15,839,244 | 15,839,244 | NS | C/T | R/C | rs61731561 (DbSNP) |
| 19 | 15,839,263 | 15,839,263 | NS | A/G | N/S | rs57001564 (DbSNP) |
| 19 | 15,839,365 | 15,839,365 | NS | T/C | F/S | rs1806931 (DbSNP) |
| 19 | 15,839,459 | 15,839,459 | SYN | A/G | L/L | rs11669315 (DbSNP) |
| 19 | 15,839,496 | 15,839,496 | NS | A/G | I/V | rs61733113 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 19 | 15,777,409 | 15,839,459 | CopyNumber | Variation_8864 (DGV) |
| 19 | 15,780,016 | 15,839,365 | CopyNumber | Variation_29687 (DGV) |
| 19 | 15,780,041 | 15,851,261 | CopyNumber | Variation_3181 (DGV) |
| 19 | 15,786,059 | 15,888,458 | Inversion | Variation_43709 (DGV) |
| 19 | 15,838,754 | 15,841,798 | CopyNumber | #101 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| S171F | I215V | % Freq | CORP | |
|---|---|---|---|---|
| 1 | S | I | 76.65 | 0.148 |
| 2 | F | I | 20.05 | 0.148 |
| 3 | S | V | 3.30 | 0.148 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR10H2.aApr07-unspliced | main_exon | 5UTR | chr19 | 15,728,024 | 15,728,044 | + |
| CDS | chr19 | 15,728,044 | 15,728,988 | + | ||
| 3UTR | chr19 | 15,728,988 | 15,729,060 | + | ||