OR10H4 Olfactory Receptor
| Gene Symbol | OR10H41 (View this gene in GeneCards) |
| Family | 10 |
| Subfamily | H |
| Pseudogene | No |
| CORP pseudogene probability score | 1 (pseudogene) |
| Aliases | OR19-28, HsOR19.4.5, ORL3760 |
| External Ids | HGNC: 15388 GeneBank: AB065921, AF399586, BK004270, NM_001004465 ORDB: ORL3760 |
| Build #39 labels | OR10H4 |
| Chromosomal location | 19:15,949,008-15,949,955 (+) |
| Cluster | 19@16b |
| Synteny | CLIC#46 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR10H3 | 89.87% | 316 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR10H4C | 82% | 309 |
| Dog | OR10H4D | 81% | 309 |
| Mouse | Or10h28 | 76% | 315 |
| Rat | Or10h28 | 77% | 315 |
| Cow | OR10H4G | 82% | 309 |
| Cow | OR10H4P | 82% | 309 |
| Cow | OR10H4H | 82% | 282 |
| Cow | OR10H4J | 82% | 278 |
| Orang | OR10H4P | 88% | 278 |
| Horse | OR10H4K | 84% | 282 |
| Horse | OR10H4L | 83% | 282 |
| Horse | OR10H4MP | 83% | 269 |
| Chimp | OR10H3 | 91% | 316 |
Sequence information
| Nucleotide sequence |
ATGCCTAGTCAGAACTATAGCATCATATCTGAATTTAACCTCTTTGGCTTCTCAGCCTTC CCCCAGCACCTCCTGCCCATCTTGTTCCTGCTGTACCTCCTGATGTTCCTGTTCACATTG CTGGGCAACCTTCTCATCATGGCCACAATCTGGATTGAACACAGACTCCACACACCCATG TACCTCTTCTTGTGCACCCTCTCCGTCTCTGAGATTCTGTTCACTGTTGCCATCACCCCT CGCATGCTGGCTGATCTGCTTTCCACCCATCATTCCATCACCTTTGTGGCTTGTGCCAAC CAGATGTTCTTCTCCTTCATGTTTGGCTTCACTCACTCCTTCCTTCTCCTGGTCATGGGC TATGATCGCTATGTGGCCATCTGCCACCCACTGCGTTACAATGTGCTCATGAGCCCCCGT GACTGTGCCCATCTTGTGGCCTGTACCTGGGCTGGTGGCTCAGTCATGGGGATGATGGTG ACAACGATAGTTTTCCACCTCACTTTCTGTGGGTCTAATGTGATCCACCATTTTTTCTGT CATGTGCTTTCCCTCTTGAAGTTGGCCTGTGAAAACAAGACATCATCTGTCATCATGGGT GTGATGCTGGTGTGTGTCACAGCCCTGATAGGCTGTTTATTCCTCATCATCCTCTCCTAT GTCTTCATTGTGGCTGCCATCTTGAGGATTCCCTCTGCCGAAGGCCGGCACAAGACATTT TCTACGTGTGTATCCCACCTCACTGTGGTGGTCACGCACTATAGTTTTGCCTCCTTTATC TACCTCAAGCCCAAGGGCCTCCATTCTATGTACAGTGACGCCTTGATGGCCACCACCTAT ACTGTCTTCACCCCCTTCCTTAGCCCAATCATTTTCAGCCTAAGGAACAAGGAGCTGAAG AATGCCATAAATAAAAACTTTTACAGAAAATTCTGTCCTCCAAGTTCC |
| Conceptual translation |
MPSQNYSIISEFNLFGFSAFPQHLLPILFLLYLLMFLFTLLGNLLIMATIWIEHRLHTPM YLFLCTLSVSEILFTVAITPRMLADLLSTHHSITFVACANQMFFSFMFGFTHSFLLLVMG YDRYVAICHPLRYNVLMSPRDCAHLVACTWAGGSVMGMMVTTIVFHLTFCGSNVIHHFFC HVLSLLKLACENKTSSVIMGVMLVCVTALIGCLFLIILSYVFIVAAILRIPSAEGRHKTF STCVSHLTVVVTHYSFASFIYLKPKGLHSMYSDALMATTYTVFTPFLSPIIFSLRNKELK NAINKNFYRKFCPPSS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 19 | 100 | -100 | NS | G/T | C/F | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI) |
| 19 | 100 | -100 | SYN | C/T | S/S | 1000GP (YRI, YRI) |
| 19 | 15,949,036 | 15,949,036 | NS | C/G | S/C | 1000GP (CEU) |
| 19 | 15,949,211 | 15,949,211 | SYN | C/T | S/S | 1000GP (CEU, CHBJPT) |
| 19 | 15,949,300 | 15,949,300 | NS | G/T | C/F | 1000GP (CEU, CHBJPT) |
| 19 | 15,949,307 | 15,949,307 | NS | C/A | N/K | 1000GP (CEU, CHBJPT) |
| 19 | 15,949,438 | 15,949,438 | NS | A/G | H/R | 1000GP (CEU, CHBJPT) |
| 19 | 15,949,457 | 15,949,457 | nonsense SNP | G/A | W/* | 1000GP (CHBJPT) |
| 19 | 15,949,848 | 15,949,848 | NS | A/G | T/A | 1000GP (CEU, CHBJPT) |
| 19 | 16,060,004 | 16,060,003 | Ins(1) | -/T | rs35723232 (DbSNP) | |
| 19 | 16,060,021 | 16,060,021 | SYN | C/T | S/S | rs16980821 (DbSNP) |
| 19 | 16,060,117 | 16,060,117 | NS | A/C | K/N | rs16980994 (DbSNP) |
| 19 | 16,060,248 | 16,060,248 | NS | A/G | H/R | rs16980822 (DbSNP) |
| 19 | 16,060,523 | 16,060,523 | NS | C/T | R/W | rs61732447 (DbSNP) |
| 19 | 16,060,658 | 16,060,658 | NS | A/G | T/A | rs11880184 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 19 | 16,031,569 | 16,060,989 | CopyNumber | Variation_89138 (DGV) |
| 19 | 16,046,049 | 16,060,989 | CopyNumber | Variation_89146 (DGV) |
| 19 | 16,059,718 | 16,062,765 | CopyNumber | #103 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| S10C | R81L | R123H | R140H | H144R | F179L | A225D | R236W | T252M | Y254H | T281A | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | S | R | R | R | H | F | A | R | T | Y | T | 71.12 | 0.362 |
| 2 | S | R | R | R | R | F | A | R | T | Y | A | 25.42 | 0.362 |
| 3 | S | R | R | R | R | F | A | W | T | Y | A | 1.31 | 0.319 |
| 4 | C | R | R | R | H | F | A | R | T | Y | T | 0.46 | 0.362 |
| 5 | S | R | R | R | H | F | D | R | T | Y | T | 0.31 | 0.362 |
| 6 | S | R | H | R | H | F | A | R | T | Y | T | 0.23 | 0.910 |
| 7 | S | R | R | R | R | F | A | R | T | H | A | 0.23 | 0.132 |
| 8 | S | R | R | R | H | F | A | R | M | Y | T | 0.23 | 0.362 |
| 9 | S | R | R | R | H | F | A | W | T | Y | T | 0.15 | 0.319 |
| 10 | S | R | R | R | R | F | A | R | T | Y | T | 0.15 | 0.362 |
| 11 | S | R | R | R | H | L | A | R | T | Y | T | 0.08 | 0.362 |
| 12 | S | R | R | R | H | F | A | R | T | Y | A | 0.08 | 0.362 |
| 13 | S | R | R | R | R | F | A | R | M | Y | A | 0.08 | 0.362 |
| 14 | S | L | R | R | R | F | A | R | T | Y | A | 0.08 | 0.362 |
| 15 | S | R | R | H | H | F | A | R | T | Y | T | 0.08 | 0.362 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR10H4.aApr07-unspliced | main_exon | CDS | chr19 | 15,949,008 | 15,949,955 | + |
| 3UTR | chr19 | 15,949,955 | 15,949,958 | + | ||