OR11G2 Olfactory Receptor

Gene Symbol	OR11G2¹ (View this gene in GeneCards)
Family	11
Subfamily	G
Pseudogene	No
CORP pseudogene probability score	0.04 (functional)
Aliases	OR14-34, HsOR14.1.25, ORL3687
External Ids	HGNC: 15346 GeneBank: AB065897, AF399610, BK004453, NM_001005503 ORDB: ORL3687
Build #39 labels	OR11G2
Chromosomal location	14:20,197,438-20,198,370 (+)
Cluster	14@20b
Synteny	CLIC#32
Remarks

Most Similar ORs in Humans (Paralogs)

Symbol	Percent	Length
OR11G1P	80.07%	306

Most Similar ORs in other species (Orthologs)

Specie	Symbol	Percent	Length
Dog	OR11G2B	80%	311
Mouse	Or11g2	82%	307
Rat	Or11g1	80%	307
Rat	Or11g2	80%	300
Cow	OR11G2C	83%	308
Orang	OR11G30P	78%	302
Horse	OR11G2G	85%	310
Horse	OR11G2F	82%	308
Chimp	OR11H6	63%	307

Expression evidences

Source	Accession
mRNA	AB463954
GNF Atlas2	gnf1h02178_at

Sequence information

Nucleotide sequence

ATGAAAATCTTCAACAGCCCCAGCAACTCCAGCACCTTCACTGGCTTCATCCTCCTGGGC
TTCCCTTGCCCCAGGGAGGGGCAGATCCTCCTCTTTGTGCTCTTCACTGTTGTTTACCTC
CTGACCCTCATGGGCAATGGTTCCATCATCTGTGCTGTGCACTGGGATCAGAGACTCCAC
GCCCCCATGTACATCCTGCTCGCCAACTTCTCCTTCTTGGAGATATGTTATGTCACCTCC
ACAGTCCCCAGCATGCTGGCCAACTTCCTCTCTGACACCAAGATCATCTCGTTCTCTGGC
TGCTTCCTCCAGTTCTACTTTTTCTTCTCCTTGGGCTCTACAGAATGCTTTTTCCTGGCA
GTTATGGCATTTGATCGATACCTTGCCATCTGTCGGCCTCTACGCTATCCAACCATTATG
ACCAGACGTCTCTGTACCAATCTTGTGGTCAATTGCTGGGTACTTGGTTTCATCTGGTTC
TTGATTCCTATCGTCAACATCTCCCAAATGTCCTTCTGTGGATCTAGGATTATTGACCAC
TTCCTATGTGACCCAGCTCCTCTTCTAACTCTCACTTGCAAAAAAGGCCCTGTGATAGAG
CTTGTCTTTTCTGTCTTAAGTCCTCTGCCTGTCTTTATGCTCTTTCTCTTCATTGTGGGG
TCCTATGCTCTGGTCGTGAGAGCTGTGTTGAGGGTCCCTTCAGCAGCTGGGAGAAGAAAG
GCTTTCTCCACCTGTGGGTCTCACCTGGCTGTGGTTTCACTGTTCTACGGCTCAGTACTG
GTCATGTATGGGAGCCCACCATCTAAGAATGAAGCTGGAAAGCAGAAGACTGTGACTCTG
TTTTATTCTGTTGTTACCCCACTGCTTAACCCTGTGATATATAGTCTTAGGAACAAAGAT
ATGAGAAAAGCTCTGAAGAAATTTTGGGGAACA

Conceptual translation

MKIFNSPSNSSTFTGFILLGFPCPREGQILLFVLFTVVYLLTLMGNGSIICAVHWDQRLH
APMYILLANFSFLEICYVTSTVPSMLANFLSDTKIISFSGCFLQFYFFFSLGSTECFFLA
VMAFDRYLAICRPLRYPTIMTRRLCTNLVVNCWVLGFIWFLIPIVNISQMSFCGSRIIDH
FLCDPAPLLTLTCKKGPVIELVFSVLSPLPVFMLFLFIVGSYALVVRAVLRVPSAAGRRK
AFSTCGSHLAVVSLFYGSVLVMYGSPPSKNEAGKQKTVTLFYSVVTPLLNPVIYSLRNKD
MRKALKKFWGT

Protein domains and features

Variations - SNPs

Chr	Start	End	Type	Variation	AA Change	SNP IDs
14	20,666,177	20,666,176	Ins(1)	-/A		rs67847713 (DbSNP)
14	20,666,182	20,666,181	Ins(1)	-/A		rs55781225 (DbSNP)
14	20,665,908	20,665,907	Ins(1)	-/A		rs61106173 (DbSNP)
14	20,665,840	20,665,840	NS	A/G	I/V	rs4981088 (DbSNP)
14	20,665,627	20,665,627	NS	A/G	S/G	rs45620333 (DbSNP)
14	20,665,790	20,665,790	NS	A/T	N/I	rs4981822 (DbSNP)
14	20,665,887	20,665,887	SYN	C/G	S/S	rs4981823 (DbSNP)
14	20,197,681	20,197,681	NS	G/A	V/I	1000GP (CEU, CHBJPT)
14	20,197,631	20,197,631	NS	T/A	I/N	1000GP (CEU, CHBJPT)
14	20,197,728	20,197,728	SYN	G/C	S/S	1000GP (CEU, CHBJPT)
14	100	-100	NS	T/A	I/N	1000GP (YRI, YRI, YRI, YRI)
14	100	-100	SYN	G/C	S/S	1000GP (YRI)
14	100	-100	nonsense SNP	C/A	C/*	1000GP (YRI)

Variations - CNVs

Chr	Start	End	Type	Sources
14	20,203,125	20,716,841	CopyNumber	Variation_8765 (DGV)

Haplotypes

Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.

	S45G	G49D	I84N	I99N	V116I	K128N	V183M	V232M	% Freq	CORP
1	S	G	I	I	V	K	V	V	48.69	0.222
2	S	G	I	N	I	K	V	V	43.39	0.222
3	S	G	I	N	I	N	M	V	3.76	0.222
4	G	D	I	I	V	K	V	V	2.07	0.222
5	S	G	I	I	I	K	V	V	1.00	0.222
6	S	G	I	I	V	K	M	V	0.31	0.222
7	S	G	I	N	V	K	V	V	0.23	0.222
8	S	G	I	I	I	N	M	V	0.15	0.222
9	S	G	I	I	V	N	M	V	0.08	0.222
10	S	D	I	I	V	K	V	V	0.08	0.222
11	S	G	N	N	I	K	V	V	0.08	0.222
12	S	G	N	I	V	K	V	V	0.08	0.222
13	S	G	I	I	V	K	V	M	0.08	0.222

AceView Gene Models

The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.

Accession	Type		Chr	Start	End	Strand
OR11G2.aApr07-unspliced	main_exon	5UTR	chr14	20,197,336	20,197,438	+
		CDS	chr14	20,197,438	20,198,370	+
		3UTR	chr14	20,198,370	20,198,373	+

HORDE

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