OR14A2 Olfactory Receptor
| Gene Symbol | OR14A21 (View this gene in GeneCards) |
| Family | 14 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.01 (functional) |
| Aliases | HsOR1.5.8 |
| External Ids | HGNC: 15024 |
| Build #39 labels | OR5AX1 |
| Chromosomal location | 1:247,723,102-247,724,043 (-) |
| Cluster | 1@248 |
| Synteny | CLIC#0 |
| Remarks | Belongs to OR14- a new family which is expanded in opossum and platypus. Was previously classified into family 5 with the symbol OR5AX1. |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR14A16 | 56.25% | 304 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR14J1B | 50% | 318 |
| Mouse | Or14a258 | 73% | 314 |
| Rat | Or14a257b | 72% | 305 |
| Cow | OR14J12 | 53% | 309 |
| Orang | OR14A16 | 55% | 310 |
| Horse | OR14P4 | 54% | 299 |
| Chimp | OR14A2P | 97% | 314 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | BE672444 |
| mRNA | AB529268 |
| GNF Atlas2 | gnf1h10652_at |
Sequence information
| Nucleotide sequence |
ATGGCCAATGTCACCTTGGTGACAGGATTTCTTCTTATGGGGTTTTCTAATATCCAGAAG CTGCGGATTTTATATGGTGTGCTCTTCCTACTGATTTACCTGGCAGCCCTAATGAGTAAC CTTCTCATCATTACTCTCATTACCCTGGACGTAAAGCTCCAAACACCCATGTACTTCTTC CTGAAGAACTTATCCTTTTTGGATGTCTTCCTGGTGTCTGTTCCAATCCCAAAATTCATT GTCAACAACCTAACCCACAACAATTCCATTTCCATTCTAGGATGTGCCTTCCAGCTACTT TTAATGACTTCCTTCTCAGCAGGAGAGATATTTATCCTCACTGCCATGTCCTATGACCGC TATGTAGCCATCTGCTGTCCCCTGAACTACGAGGTAATCATGAATACTGGAGTCTGTGTG TTAATGGCAAGTGTTTCCTGGGCCATTGGAGGGCTCTTTGGTACTGCGTACACAGCTGGC ACATTTTCCATGCCTTTCTGTGGCTCCAGTGTGATTCCACAGTTTTTCTGTGATGTTCCT TCATTACTAAGGATTTCCTGTTCTGAAACACTAATGGTAATTTATGCAGGTATTGGAGTT GGTGCATGTTTAAGCATTTCTTGTTTCATCTGTATTGTGATCTCTTACATTTATATCTTC TCCACTGTACTGAAGATCCCTACCACTAAAGGTCAGTCCAAAGCTTTTTCCACATGCTTC CCCCATCTCACTGTTTTCACTGTTTTTATCATAACTGCTTATTTTGTTTATCTTAAGCCA CCTTCAAATTCACCATCTGTTATTGACAGGCTGCTTTCTGTGATCTACACTGTGATGCCT CCAGTATTTAACCCTGTAACCTACAGCCTGCGGAACAATGACATGAAATGTGCTCTGATA AGGTTGCTGCAGAAAACATATGGTCAGGAGGCTTACTTCATT |
| Conceptual translation |
MANVTLVTGFLLMGFSNIQKLRILYGVLFLLIYLAALMSNLLIITLITLDVKLQTPMYFF LKNLSFLDVFLVSVPIPKFIVNNLTHNNSISILGCAFQLLLMTSFSAGEIFILTAMSYDR YVAICCPLNYEVIMNTGVCVLMASVSWAIGGLFGTAYTAGTFSMPFCGSSVIPQFFCDVP SLLRISCSETLMVIYAGIGVGACLSISCFICIVISYIYIFSTVLKIPTTKGQSKAFSTCF PHLTVFTVFIITAYFVYLKPPSNSPSVIDRLLSVIYTVMPPVFNPVTYSLRNNDMKCALI RLLQKTYGQEAYFI Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 100 | -100 | NS | G/A | P/S | 1000GP (YRI, YRI, YRI, YRI) |
| 1 | 247,723,191 | 247,723,191 | NS | G/A | P/S | 1000GP (CEU) |
| 1 | 247,723,313 | 247,723,313 | NS | G/A | T/I | 1000GP (CEU) |
| 1 | 247,723,647 | 247,723,647 | NS | T/C | I/V | 1000GP (CEU) |
| 1 | 247,723,700 | 247,723,700 | NS | G/A | A/V | 1000GP (CHBJPT) |
| 1 | 247,886,493 | 247,886,493 | SNP | A/G | rs62619787 (DbSNP) | |
| 1 | 247,886,505 | 247,886,505 | SNP | G/T | rs62619785 (DbSNP) | |
| 1 | 247,886,615 | 247,886,615 | SNP | A/G | rs11809582 (DbSNP) | |
| 1 | 247,886,949 | 247,886,949 | SNP | C/T | rs36075193 (DbSNP) | |
| 1 | 247,887,002 | 247,887,002 | SNP | A/G | rs11204577 (DbSNP) | |
| 1 | 247,887,069 | 247,887,069 | SNP | C/G | rs1338393 (DbSNP) | |
| 1 | 247,887,122 | 247,887,122 | SNP | A/G | rs56268113 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| P285S | P281T | T244I | S233F | V140L | I133V | A115V | P75L | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | P | P | T | S | V | I | A | P | 78.34 | 0.011 |
| 2 | P | P | T | S | V | I | V | P | 5.68 | 0.011 |
| 3 | P | P | T | S | V | V | A | P | 5.53 | 0.011 |
| 4 | P | P | I | S | V | I | A | P | 4.69 | 0.011 |
| 5 | S | P | I | S | V | I | A | P | 4.38 | 0.279 |
| 6 | P | T | I | S | V | I | A | P | 0.69 | 0.020 |
| 7 | P | P | T | F | V | I | A | P | 0.38 | 0.011 |
| 8 | P | P | T | S | L | I | A | P | 0.08 | 0.011 |
| 9 | S | P | T | S | V | I | A | P | 0.08 | 0.279 |
| 10 | P | P | T | S | V | V | A | L | 0.08 | 0.011 |
| 11 | P | P | T | S | V | I | A | L | 0.08 | 0.011 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| 7tm_1.13.aApr07 | main_exon | CDS_partial | chr1 | 247,723,766 | 247,724,043 | - |
| 5UTR | chr1 | 247,724,043 | 247,724,062 | - | ||
| exon_5UTR | chr1 | 247,733,283 | 247,733,324 | - | ||
| OR5AX1andOR6F1.eApr07 | main_exon | chr1 | 247,722,957 | 247,723,234 | - | |
| main_exon | chr1 | 247,723,353 | 247,723,454 | - | ||
| main_exon | 3UTR | chr1 | 247,722,957 | 247,723,102 | - | |
| CDS_partial | chr1 | 247,723,102 | 247,723,234 | - | ||
| CDS_partial | chr1 | 247,723,353 | 247,723,454 | - | ||
| CDS_partial | chr1 | 247,723,651 | 247,723,761 | - | ||