OR14K1 Olfactory Receptor
| Gene Symbol | OR14K11 (View this gene in GeneCards) |
| Family | 14 |
| Subfamily | K |
| Pseudogene | No |
| CORP pseudogene probability score | 1 (pseudogene) |
| Aliases | HsOR1.5.9 |
| External Ids | HGNC: 15025 |
| Build #39 labels | OR5AY1 |
| Chromosomal location | 1:247,738,615-247,739,556 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#0 |
| Remarks | Belongs to OR14- a new family which is expanded in opossum and platypus. Was previously classified into family 5 with the symbol OR5AY1. |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR14A16 | 51.47% | 307 |
| OR14L1P | 49.48% | 287 |
| OR14A2 | 51.16% | 303 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR14J1B | 51% | 303 |
| Mouse | Or14p1 | 51% | 303 |
| Rat | Or14p1 | 51% | 301 |
| Cow | OR14P2 | 51% | 303 |
| Orang | OR14K1P | 94% | 314 |
| Horse | OR14P4 | 52% | 301 |
| Chimp | OR14A262 | 53% | 302 |
Expression evidences
| Source | Accession |
|---|---|
| GNF Atlas2 | gnf1h10916_at |
Sequence information
| Nucleotide sequence |
ATGACCAATCAGACACAGATGATGGAATTCTTGCTTGTGAGATTTACTGAGAATTGGGTG CTCCTGAGGCTGCATGCTTTGCTCTTCTCACTGATCTACCTCACGGCTGTGCTGATGAAT TTAGTCATCATTCTCCTCATGATTCTGGACCATCGTCTCCACATGGCAATGTACTTTTTC CTCCGACATTTGTCCTTCTTAGACCTGTGTCTCATTTCTGCCACAGTCCCCAAATCCATC CTCAACTCTGTCGCCTCCACTGACTCCATCTCCTTCCTGGGGTGTGTGTTGCAGCTCTTC TTGGTGGTACTGCTGGCTGGATCAGAGATTGGCATCCTTACTGCCATGTCCTATGACCGC TATGCTGCCATCTGCTGCCCCCTACACTGTGAGGCTGTCATGAGCAGAGGGCTCTGTGTC CAGTTGATGGCTCTGTCCTGGCTCAACAGAGGGGCCTTGGGACTCTTGTACACAGCTGGA ACATTCTCTCTGAATTTTTATGGCTCTGATGAGCTACATCAGTTCTTCTGCGATGTCCCT GCCCTACTAAAGCTCACTTGTTCTAAAGAACATGCCATCATTAGTGTCAGTGTGGCCATT GGGGTCTGTTATGCATTTTCATGTTTAGTTTGCATTGTAGTTTCCTATGTGTACATTTTC TCTGCTGTGTTAAGGATATCACAGAGACAGAGACAATCCAAAGCCTTTTCCAACTGTGTG CCTCACCTCATTGTTGTCACTGTGTTTCTTGTAACAGGTGCTGTTGCTTATTTAAAGCCA GGGTCTGATGCACCTTCTATTCTAGACTTGCTGGTGTCTGTGTTCTATTCTGTCGCACCT CCAACCTTGAACCCTGTTATCTACTGTCTGAAGAACAAGGACATTAAATCCGCTCTGAGT AAAGTCCTGTGGAATGTTAGAAGCAGTGGGGTAATGAAAAGA |
| Conceptual translation |
MTNQTQMMEFLLVRFTENWVLLRLHALLFSLIYLTAVLMNLVIILLMILDHRLHMAMYFF LRHLSFLDLCLISATVPKSILNSVASTDSISFLGCVLQLFLVVLLAGSEIGILTAMSYDR YAAICCPLHCEAVMSRGLCVQLMALSWLNRGALGLLYTAGTFSLNFYGSDELHQFFCDVP ALLKLTCSKEHAIISVSVAIGVCYAFSCLVCIVVSYVYIFSAVLRISQRQRQSKAFSNCV PHLIVVTVFLVTGAVAYLKPGSDAPSILDLLVSVFYSVAPPTLNPVIYCLKNKDIKSALS KVLWNVRSSGVMKR Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 247,901,983 | 247,901,983 | SNP | A/C | rs41305743 (DbSNP) | |
| 1 | 247,902,448 | 247,902,448 | SNP | A/G | rs61731398 (DbSNP) | |
| 1 | 247,902,677 | 247,902,677 | SNP | C/T | rs61731394 (DbSNP) | |
| 1 | 247,902,693 | 247,902,693 | SNP | G/T | rs61731393 (DbSNP) | |
| 1 | 247,902,408 | 247,902,408 | SNP | G/T | rs61731395 (DbSNP) | |
| 1 | 247,738,681 | 247,738,681 | SYN | A/C | R/R | 1000GP (CEU) |
| 1 | 247,738,636 | 247,738,636 | NS | A/G | M/V | 1000GP (CHBJPT) |
| 1 | 100 | -100 | NS | G/A | R/H | 1000GP (YRI, YRI, YRI) |
| 1 | 100 | -100 | SYN | G/T | L/L | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
| 1 | 247,901,817 | 247,904,858 | CopyNumber | #108 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| M8V | R52C | M134K | D178N | A254V | K259N | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | M | R | M | D | A | K | 94.85 | 1.000 |
| 2 | M | R | M | D | A | N | 2.23 | 1.000 |
| 3 | M | R | M | N | A | K | 1.23 | 1.000 |
| 4 | M | R | M | N | V | K | 1.00 | 1.000 |
| 5 | M | C | M | D | A | K | 0.31 | 1.000 |
| 6 | V | R | M | D | A | K | 0.15 | 1.000 |
| 7 | M | R | M | D | V | K | 0.15 | 1.000 |
| 8 | M | R | K | D | A | K | 0.08 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR5AY1.aApr07-unspliced | main_exon | CDS | chr1 | 247,738,615 | 247,739,556 | + |
| 3UTR | chr1 | 247,739,556 | 247,739,559 | + | ||