OR1A1 Olfactory Receptor
| Gene Symbol | OR1A11 (View this gene in GeneCards) |
| Family | 1 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR17-7, OR17-11, HsOR17.1.7, ORL512, ORL741 |
| External Ids | HGNC: 8179 GeneBank: AF087918, AF399555, BC069169, BK004241, NM_014565 ORDB: ORL512, ORL741 |
| Build #39 labels | OR1A1 |
| Chromosomal location | 17:3,215,621-3,216,547 (+) |
| Cluster | 17@3b |
| Synteny | CLIC#39 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs2073153) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR1A2 | 83.5% | 309 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR1A4P | 74% | 301 |
| Mouse | Or1a1 | 84% | 309 |
| Mouse | Or1a1b | 84% | 309 |
| Rat | Or1a1b | 83% | 304 |
| Rat | Or1a1 | 82% | 305 |
| Cow | OR1A1D | 86% | 309 |
| Cow | OR1A1C | 86% | 309 |
| Orang | OR1A1P | 95% | 307 |
| Horse | OR1A1F | 86% | 309 |
| Horse | OR1A1IP | 84% | 309 |
| Chimp | OR1A2P | 82% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | AB529296 |
| GNF Atlas2 | 221388_at |
Sequence information
| Nucleotide sequence |
ATGAGGGAAAATAACCAGTCCTCTACACTGGAATTCATCCTCCTGGGAGTTACTGGTCAG CAGGAACAGGAAGATTTCTTCTACATCCTCTTCTTGTTCATTTACCCCATCACATTGATT GGAAACCTGCTCATCGTCCTAGCCATTTGCTCTGATGTTCGCCTTCACAACCCCATGTAT TTTCTCCTTGCCAACCTCTCCTTGGTTGACATCTTCTTCTCATCGGTAACCATCCCTAAG ATGCTGGCCAACCATCTCTTGGGCAGCAAATCCATCTCTTTTGGGGGATGCCTAACGCAG ATGTATTTCATGATAGCCTTGGGTAACACAGACAGCTATATTTTGGCTGCAATGGCATAT GATCGAGCTGTGGCCATCAGCCGCCCACTTCACTACACAACAATTATGAGTCCACGGTCT TGTATCTGGCTTATTGCTGGGTCTTGGGTGATTGGAAATGCCAATGCCCTCCCCCACACT CTGCTCACAGCTAGTCTGTCCTTCTGTGGCAACCAGGAAGTGGCCAACTTCTACTGTGAC ATTACCCCCTTGCTGAAGTTATCCTGTTCTGACATCCACTTTCATGTGAAGATGATGTAC CTAGGGGTTGGCATTTTCTCTGTGCCATTACTATGCATCATTGTCTCCTATATTCGAGTC TTCTCCACAGTCTTCCAGGTTCCTTCCACCAAGGGCGTGCTCAAGGCCTTCTCCACCTGT GGTTCCCACCTCACGGTTGTCTCTTTGTATTATGGTACAGTCATGGGCACGTATTTCCGC CCTTTGACCAATTATAGCCTAAAAGACGCAGTGATCACTGTAATGTACACGGCAGTGACC CCAATGTTAAATCCTTTCATCTACAGTCTGAGAAATCGGGACATGAAGGCTGCCCTGCGG AAACTCTTCAACAAGAGAATCTCCTCG |
| Conceptual translation |
MRENNQSSTLEFILLGVTGQQEQEDFFYILFLFIYPITLIGNLLIVLAICSDVRLHNPMY FLLANLSLVDIFFSSVTIPKMLANHLLGSKSISFGGCLTQMYFMIALGNTDSYILAAMAY DRAVAISRPLHYTTIMSPRSCIWLIAGSWVIGNANALPHTLLTASLSFCGNQEVANFYCD ITPLLKLSCSDIHFHVKMMYLGVGIFSVPLLCIIVSYIRVFSTVFQVPSTKGVLKAFSTC GSHLTVVSLYYGTVMGTYFRPLTNYSLKDAVITVMYTAVTPMLNPFIYSLRNRDMKAALR KLFNKRISS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 17 | 100 | -100 | NS | G/A | R/H | 1000GP (YRI, YRI, YRI, YRI) |
| 17 | 100 | -100 | SYN | T/C | L/L | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 17 | 3,119,008 | 3,119,008 | SYN | C/T | L/L | rs4325604 (DbSNP) |
| 17 | 3,119,049 | 3,119,049 | SYN | C/T | I/I | rs4374201 (DbSNP) |
| 17 | 3,119,297 | 3,119,297 | NS | A/G | H/R | rs4375699 (DbSNP) |
| 17 | 3,119,397 | 3,119,397 | SYN | G/T | L/L | rs769425 (DbSNP) |
| 17 | 3,119,611 | 3,119,611 | NS | A/G | M/V | rs17762735 (DbSNP) |
| 17 | 3,119,648 | 3,119,648 | NS | A/C | K/T | rs62090945 (DbSNP) |
| 17 | 3,119,673 | 3,119,673 | SYN | A/G | T/T | rs769426 (DbSNP) |
| 17 | 3,119,744 | 3,119,744 | NS | C/T | T/M | rs61737301 (DbSNP) |
| 17 | 3,119,767 | 3,119,767 | NS | C/T | P/S | rs769427 (DbSNP) |
| 17 | 3,215,714 | 3,215,714 | SYN | T/C | L/L | 1000GP (CEU, CHBJPT) |
| 17 | 3,215,755 | 3,215,755 | SYN | C/T | I/I | 1000GP (CEU) |
| 17 | 3,216,003 | 3,216,003 | NS | G/A | R/H | 1000GP (CEU) |
| 17 | 3,216,103 | 3,216,103 | SYN | G/T | L/L | 1000GP (CEU) |
| 17 | 3,216,315 | 3,216,315 | NS | G/A | G/D | 1000GP (CEU) |
| 17 | 3,216,317 | 3,216,317 | NS | G/A | V/M | 1000GP (CEU) |
| 17 | 3,216,379 | 3,216,379 | SYN | A/G | T/T | 1000GP (CEU) |
| 17 | 3,216,473 | 3,216,473 | NS | C/T | P/S | 1000GP (CEU, CHBJPT) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 17 | 3,018,447 | 3,159,865 | CopyNumber | Variation_2217 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R122* | R128H | V233M | T277M | M282V | P285S | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | R | R | V | T | M | P | 51.61 | 0.066 |
| 2 | R | R | V | T | M | S | 34.18 | 0.715 |
| 3 | R | H | V | T | M | P | 5.76 | 0.066 |
| 4 | R | R | M | T | M | P | 5.30 | 0.066 |
| 5 | R | R | M | M | M | P | 2.76 | 0.066 |
| 6 | R | R | V | T | V | P | 0.23 | 0.066 |
| 7 | * | R | V | T | M | P | 0.08 | 1.200 |
| 8 | R | H | V | T | M | S | 0.08 | 0.715 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR1A1.aApr07-unspliced | main_exon | CDS | chr17 | 3,215,621 | 3,216,547 | + |
| 3UTR | chr17 | 3,216,547 | 3,216,550 | + | ||