OR1A2 Olfactory Receptor
| Gene Symbol | OR1A21 (View this gene in GeneCards) |
| Family | 1 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.07 (functional) |
| Aliases | OR17-6, OR17-10, HsOR17.1.6, ORL3339, ORL740 |
| External Ids | HGNC: 8180 GeneBank: AF155225, AF399556, BC069092, BK004242, NM_012352 ORDB: ORL3339, ORL740 |
| Build #39 labels | OR1A2 |
| Chromosomal location | 17:3,197,519-3,198,445 (+) |
| Cluster | 17@3b |
| Synteny | CLIC#39 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR1A1 | 83.5% | 309 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR1A1 | 79% | 308 |
| Mouse | Or1a1 | 77% | 309 |
| Rat | Or1a1b | 77% | 303 |
| Cow | OR1A1D | 82% | 309 |
| Cow | OR1A1 | 81% | 309 |
| Orang | OR1A2P | 93% | 309 |
| Horse | OR1A1 | 81% | 309 |
| Horse | OR1A1IP | 80% | 309 |
| Chimp | OR1A2P | 98% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | CO247893 |
| mRNA | AB529297 |
| GNF Atlas2 | 221445_at |
Sequence information
| Nucleotide sequence |
ATGAAGAAAGAAAATCAATCCTTTAACCTGGATTTTATTCTCCTGGGAGTTACTAGTCAG CAAGAACAGAATAATGTCTTCTTTGTGATTTTTTTGTGCATTTACCCCATCACACTGACT GGAAATCTGCTCATCATCTTGGCCATCTGTGCTGACATTCGCCTTCACAACCCCATGTAT TTTCTCCTTGCCAACCTCTCCTTGGTTGACATCATCTTCTCATCCGTAACCATCCCTAAG GTGCTGGCCAACCATCTCTTGGGGAGCAAGTTCATCTCCTTTGGGGGATGCCTAATGCAG ATGTATTTCATGATAGCCTTGGCCAAGGCAGACAGCTATACCTTGGCTGCAATGGCATAC GATCGAGCTGTGGCCATCAGCTGCCCACTTCATTACACAACAATTATGAGTCCACGGTCT TGTATCCTGCTTATTGCTGGGTCTTGGGTGATTGGAAACACCAGTGCTCTCCCCCACACT CTGCTCACAGCTAGTTTGTCCTTCTGTGGCAACCAGGAAGTAGCCAATTTCTACTGTGAC ATTATGCCTTTGCTGAAGTTGTCCTGTTCTGACGTCCACTTTAATGTGAAGATGATGTAC CTAGGGGTCGGCGTTTTCTCTTTGCCATTACTATGCATCATTGTCTCCTATGTTCAGGTC TTTTCCACAGTCTTCCAAGTTCCATCTACCAAGAGTCTATTCAAAGCCTTCTGCACCTGT GGCTCCCACCTCACAGTTGTTTTTTTATATTATGGTACAACGATGGGCATGTATTTCCGC CCTCTGACCAGTTACAGCCCCAAAGATGCAGTGATAACTGTGATGTATGTGGCAGTGACC CCAGCATTAAATCCTTTCATCTATAGTCTGAGAAATTGGGATATGAAGGCAGCCCTACAG AAACTCTTCAGCAAGAGAATCTCCTCA |
| Conceptual translation |
MKKENQSFNLDFILLGVTSQQEQNNVFFVIFLCIYPITLTGNLLIILAICADIRLHNPMY FLLANLSLVDIIFSSVTIPKVLANHLLGSKFISFGGCLMQMYFMIALAKADSYTLAAMAY DRAVAISCPLHYTTIMSPRSCILLIAGSWVIGNTSALPHTLLTASLSFCGNQEVANFYCD IMPLLKLSCSDVHFNVKMMYLGVGVFSLPLLCIIVSYVQVFSTVFQVPSTKSLFKAFCTC GSHLTVVFLYYGTTMGMYFRPLTSYSPKDAVITVMYVAVTPALNPFIYSLRNWDMKAALQ KLFSKRISS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 17 | 100 | -100 | NS | C/A | A/E | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 17 | 100 | -100 | SYN | T/C | N/N | 1000GP (YRI, YRI, YRI) |
| 17 | 3,100,827 | 3,100,827 | SYN | T/C | N/N | rs2241093 (DbSNP) |
| 17 | 3,101,076 | 3,101,076 | SYN | C/G | G/G | rs2241092 (DbSNP) |
| 17 | 3,101,141 | 3,101,141 | NS | A/C | E/A | rs59497198 (DbSNP) |
| 17 | 3,101,172 | 3,101,172 | SYN | C/T | Y/Y | rs57842312 (DbSNP) |
| 17 | 3,101,542 | 3,101,542 | NS | C/T | L/F | rs56058341 (DbSNP) |
| 17 | 3,101,578 | 3,101,578 | NS | T/G | C/G | rs2241091 (DbSNP) |
| 17 | 3,101,590 | 3,101,590 | NS | C/T | R/C | rs2469791 (DbSNP) |
| 17 | 3,101,691 | 3,101,691 | NS | G/T | W/C | rs12150427 (DbSNP) |
| 17 | 3,197,533 | 3,197,533 | SYN | T/C | N/N | 1000GP (CEU, CHBJPT) |
| 17 | 3,197,782 | 3,197,782 | SYN | G/C | G/G | 1000GP (CEU, CHBJPT) |
| 17 | 3,198,279 | 3,198,279 | NS | C/T | T/M | 1000GP (CHBJPT) |
| 17 | 3,198,284 | 3,198,284 | NS | G/T | G/C | 1000GP (CEU, CHBJPT) |
| 17 | 3,198,296 | 3,198,296 | NS | C/T | R/C | 1000GP (CEU) |
| 17 | 3,198,397 | 3,198,397 | NS | G/T | W/C | 1000GP (CEU, CHBJPT) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 17 | 3,018,447 | 3,159,865 | CopyNumber | Variation_2217 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| A110E | M118T | T163I | L244F | T254M | G256C | R260C | R260H | I287F | W293C | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | A | M | T | L | T | G | R | R | I | W | 47.16 | 0.197 |
| 2 | A | M | T | L | T | C | R | R | I | C | 30.57 | 0.197 |
| 3 | A | M | T | L | T | G | C | R | I | W | 15.13 | 0.197 |
| 4 | E | M | T | F | T | G | R | R | I | W | 2.84 | 0.197 |
| 5 | A | M | T | L | M | G | R | R | I | W | 0.84 | 0.197 |
| 6 | A | M | T | L | T | G | R | R | F | C | 0.77 | 0.197 |
| 7 | A | M | T | L | T | G | R | H | I | W | 0.77 | 0.197 |
| 8 | A | M | T | L | T | C | R | R | I | W | 0.38 | 0.197 |
| 9 | A | M | T | L | T | G | C | R | I | C | 0.38 | 0.197 |
| 10 | A | M | T | L | T | G | R | R | I | C | 0.31 | 0.197 |
| 11 | A | M | T | L | T | C | C | R | I | W | 0.23 | 0.197 |
| 12 | A | M | T | L | T | C | R | H | I | C | 0.15 | 0.197 |
| 13 | A | T | T | L | T | G | R | R | I | W | 0.15 | 0.496 |
| 14 | A | M | T | L | T | C | C | R | I | C | 0.08 | 0.197 |
| 15 | A | M | T | L | T | G | C | H | I | W | 0.08 | 0.197 |
| 16 | E | M | T | F | T | G | C | R | I | W | 0.08 | 0.197 |
| 17 | A | M | I | L | T | G | R | R | I | W | 0.08 | 0.197 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR1A2.aApr07-unspliced | main_exon | 5UTR | chr17 | 3,197,509 | 3,197,519 | + |
| CDS | chr17 | 3,197,519 | 3,198,445 | + | ||
| 3UTR | chr17 | 3,198,445 | 3,198,457 | + | ||