OR1L8 Olfactory Receptor
| Gene Symbol | OR1L81 (View this gene in GeneCards) |
| Family | 1 |
| Subfamily | L |
| Pseudogene | No |
| CORP pseudogene probability score | 0.01 (functional) |
| Aliases | OR9-24, HsOR9.6.6, ORL3216 |
| External Ids | HGNC: 15110 GeneBank: AB065721, AF399564, BK004447, NM_001004454 ORDB: ORL3216 |
| Build #39 labels | OR1L8 |
| Chromosomal location | 9:122,567,551-122,568,477 (-) |
| Cluster | 9@125 |
| Synteny | CLIC#21 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR1L1 | 69.64% | 303 |
| OR1L3 | 68.42% | 304 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR1L11P | 62% | 319 |
| Mouse | Or1l8 | 85% | 308 |
| Rat | Or1l8 | 84% | 308 |
| Cow | OR1L8E | 80% | 308 |
| Orang | OR1L8P | 94% | 309 |
| Horse | OR1L8KP | 75% | 315 |
| Chimp | OR1L1 | 69% | 303 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | AB529308 |
| GNF Atlas2 | gnf1h10933_at |
Sequence information
| Nucleotide sequence |
ATGGAAAGAATCAACCACACCAGCAGTGTCTCCGAGTTTATCCTCCTGGGACTCTCCTCC CGGCCTGAGGACCAAAAGACACTCTTTGTTCTCTTCCTCATCGTGTACCTGGTCACCATA ACAGGGAACCTGCTCATCATCCTGGCCATTCGCTTCAACCCCCATCTTCAGACCCCTATG TATTTCTTCTTGAGTTTTCTGTCTCTCACTGATATTTGCTTTACAACAAGCGTTGTCCCC AAGATGCTGATGAACTTCCTGTCAGAAAAGAAGACCATCTCCTATGCTGGGTGTCTGACA CAGATGTATTTTCTCTATGCCTTGGGCAACAGTGACAGCTGCCTTCTGGCAGTCATGGCC TTTGACCGCTATGTGGCCGTCTGTGACCCTTTCCACTATGTCACCACCATGAGCCACCAC CACTGTGTCCTGCTGGTGGCCTTCTCCTGCTCATTTCCTCACCTCCACTCACTCCTGCAC ACACTTCTGCTGAATCGTCTCACCTTCTGTGACTCCAATGTTATCCACCACTTTCTCTGT GACCTCAGCCCTGTGCTGAAATTGTCCTGCTCTTCCATATTTGTCAATGAAATTGTGCAG ATGACAGAAGCACCTATTGTTTTGGTGACTCGTTTTCTCTGCATTGCTTTCTCTTATATA CGAATCCTCACTACAGTTCTCAAGATTCCCTCTACTTCTGGGAAACGCAAAGCCTTCTCC ACCTGTGGTTTTTACCTCACCGTGGTGACGCTCTTTTATGGAAGCATCTTCTGTGTCTAT TTACAGCCCCCATCCACCTACGCTGTCAAGGACCACGTGGCAACAATTGTTTACACAGTT TTGTCATCCATGCTCAATCCTTTTATCTACAGCCTGAGAAACAAAGACCTGAAACAGGGC CTGAGGAAGCTTATGAGCAAGAGATCC |
| Conceptual translation |
MERINHTSSVSEFILLGLSSRPEDQKTLFVLFLIVYLVTITGNLLIILAIRFNPHLQTPM YFFLSFLSLTDICFTTSVVPKMLMNFLSEKKTISYAGCLTQMYFLYALGNSDSCLLAVMA FDRYVAVCDPFHYVTTMSHHHCVLLVAFSCSFPHLHSLLHTLLLNRLTFCDSNVIHHFLC DLSPVLKLSCSSIFVNEIVQMTEAPIVLVTRFLCIAFSYIRILTTVLKIPSTSGKRKAFS TCGFYLTVVTLFYGSIFCVYLQPPSTYAVKDHVATIVYTVLSSMLNPFIYSLRNKDLKQG LRKLMSKRS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 9 | 125,330,125 | 125,330,125 | NS | C/G | R/P | rs10739614 (DbSNP) |
| 9 | 125,330,678 | 125,330,678 | NS | G/T | P/T | rs10985704 (DbSNP) |
| 9 | 125,330,240 | 125,330,240 | NS | G/T | H/N | rs72751258 (DbSNP) |
| 9 | 125,330,275 | 125,330,275 | NS | G/T | T/K | rs62621011 (DbSNP) |
| 9 | 125,330,184 | 125,330,184 | SYN | A/C | S/S | rs10985702 (DbSNP) |
| 9 | 125,330,739 | 125,330,739 | SYN | A/G | H/H | rs1999182 (DbSNP) |
| 9 | 125,330,724 | 125,330,724 | SYN | A/G | S/S | rs41305505 (DbSNP) |
| 9 | 125,330,325 | 125,330,325 | SYN | C/G | L/L | rs10985703 (DbSNP) |
| 9 | 122,567,742 | 122,567,742 | NS | G/A | L/F | 1000GP (CEU) |
| 9 | 122,568,460 | 122,568,460 | SYN | G/A | H/H | 1000GP (CEU, CHBJPT) |
| 9 | 122,568,046 | 122,568,046 | SYN | C/G | L/L | 1000GP (CEU, CHBJPT) |
| 9 | 122,567,846 | 122,567,846 | NS | C/G | R/P | 1000GP (CEU, CHBJPT) |
| 9 | 122,568,399 | 122,568,399 | NS | T/G | T/P | 1000GP (CEU) |
| 9 | 122,567,905 | 122,567,905 | SYN | A/C | S/S | 1000GP (CEU, CHBJPT) |
| 9 | 122,567,659 | 122,567,659 | SYN | C/T | V/V | 1000GP (CEU) |
| 9 | 122,568,470 | 122,568,470 | NS | C/A | R/I | 1000GP (CHBJPT) |
| 9 | 100 | -100 | NS | C/G | R/P | 1000GP (YRI, YRI, YRI, YRI) |
| 9 | 100 | -100 | SYN | A/C | S/S | 1000GP (YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 9 | 125,327,830 | 125,330,856 | CopyNumber | #116 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R221* | R211P | N173S | N173H | R51C | T27P | L15F | R3I | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | R | P | N | N | R | P | L | R | 63.36 | 0.052 |
| 2 | R | R | N | N | R | T | L | R | 25.04 | 0.024 |
| 3 | R | P | N | N | R | T | L | R | 6.22 | 0.052 |
| 4 | R | P | N | N | R | P | F | R | 2.38 | 0.052 |
| 5 | R | P | N | H | R | P | L | R | 0.77 | 0.052 |
| 6 | R | P | N | N | R | P | L | I | 0.69 | 0.052 |
| 7 | R | P | S | N | R | P | L | R | 0.54 | 0.052 |
| 8 | R | R | N | N | C | T | L | R | 0.46 | 0.024 |
| 9 | R | R | N | N | R | P | L | R | 0.31 | 0.024 |
| 10 | * | P | N | N | R | P | L | R | 0.23 | 1.200 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR1L8.aApr07-unspliced | main_exon | 3UTR | chr9 | 122,567,548 | 122,567,551 | - |
| CDS | chr9 | 122,567,551 | 122,568,477 | - | ||