OR2A12 Olfactory Receptor
| Gene Symbol | OR2A121 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.07 (functional) |
| Aliases | OR7-10, HsOR7.6.12 |
| External Ids | HGNC: 15082 GeneBank: AB065694, AF399462, AF546378-AF546391, BK004419, NM_001004135 |
| Build #39 labels | OR2A12 |
| Chromosomal location | 7:144,095,108-144,096,037 (+) |
| Cluster | 7@144 |
| Synteny | CLIC#16 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2A14 | 74.68% | 308 |
| OR2A2 | 70.32% | 310 |
| OR2A5 | 76.77% | 310 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2A14 | 82% | 308 |
| Mouse | Or2a12 | 86% | 307 |
| Rat | Or2a12-ps | 82% | 311 |
| Cow | OR2A14B | 79% | 310 |
| Orang | OR2A12P | 95% | 310 |
| Horse | OR2A14 | 79% | 308 |
| Chimp | OR2A5 | 77% | 310 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136903 |
Sequence information
| Nucleotide sequence |
ATGGAAAGCAATCAGACCTGGATCACAGAAGTCATCCTGTTGGGATTCCAGGTGGACCCA GCTCTGGAGTTGTTCCTCTTTGGGTTTTTCTTGCTATTCTACAGCTTAACCCTGATGGGA AATGGGATTATCCTGGGGCTCATCTACTTGGACTCTAGACTGCACACACCCATGTATGTC TTCCTGTCACACCTGGCCATTGTGGACATGTCCTATGCCTCGAGTACTGTCCCTAAGATG CTAGCAAATCTTGTGATGCACAAAAAAGTCATCTCCTTTGCTCCTTGCATACTTCAGACT TTTTTGTATTTGGCGTTTGCTATTACAGAGTGTCTGATTTTGGTGATGATGTGCTATGAT CGGTATGTGGCAATCTGTCACCCCTTGCAATACACCCTCATTATGAACTGGAGAGTGTGC ACTGTCCTGGCCTCAACTTGCTGGATATTTAGCTTTCTCTTGGCTCTGGTCCATATTACT CTTATTCTGAGGCTGCCTTTTTGTGGCCCACAAAAGATCAACCACTTTTTCTGTCAAATC ATGTCCGTATTCAAATTGGCCTGTGCTGACACTAGGCTCAACCAGGTGGTCCTATTTGCG GGTTCTGCGTTCATCTTAGTGGGGCCGCTCTGCCTGGTGCTGGTCTCCTACTTGCACATC CTGGTGGCCATCTTGAGGATCCAGTCTGGGGAGGGCCGCAGAAAGGCCTTCTCTACCTGC TCCTCCCACCTCTGCGTGGTGGGGCTTTTCTTTGGCAGCGCCATTGTCATGTACATGGCC CCCAAGTCAAGCCATTCTCAAGAACGGAGGAAGATCCTTTCCCTGTTTTACAGCCTTTTC AACCCGATCCTGAACCCCCTCATCTACAGCCTTAGGAATGCAGAGGTGAAAGGGGCTCTA AAGAGAGTCCTTTGGAAACAGAGATCAATG |
| Conceptual translation |
MESNQTWITEVILLGFQVDPALELFLFGFFLLFYSLTLMGNGIILGLIYLDSRLHTPMYV FLSHLAIVDMSYASSTVPKMLANLVMHKKVISFAPCILQTFLYLAFAITECLILVMMCYD RYVAICHPLQYTLIMNWRVCTVLASTCWIFSFLLALVHITLILRLPFCGPQKINHFFCQI MSVFKLACADTRLNQVVLFAGSAFILVGPLCLVLVSYLHILVAILRIQSGEGRRKAFSTC SSHLCVVGLFFGSAIVMYMAPKSSHSQERRKILSLFYSLFNPILNPLIYSLRNAEVKGAL KRVLWKQRSM Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 7 | 143,792,867 | 143,792,867 | NS | A/G | T/A | rs9655672 (DbSNP) |
| 7 | 143,792,991 | 143,792,991 | NS | A/G | N/S | rs34947817 (DbSNP) |
| 7 | 144,095,898 | 144,095,898 | NS | G/A | S/N | 1000GP (CEU) |
| 7 | 100 | -100 | NS | G/A | S/N | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 7 | 143,147,775 | 144,368,638 | CopyNumber | Variation_3708 (DGV) |
| 7 | 143,742,520 | 143,847,474 | CopyNumber | Variation_4570 (DGV) |
| 7 | 143,572,286 | 143,866,532 | CopyNumber | Variation_8581 (DGV) |
| 7 | 143,217,296 | 144,074,520 | CopyNumber | Variation_32962 (DGV) |
| 7 | 143,545,719 | 143,874,190 | CopyNumber | Variation_53583 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| I91N | R138S | M181T | A223T | S264N | L279F | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | I | R | M | A | S | L | 84.87 | 0.166 |
| 2 | I | R | M | A | N | L | 12.29 | 0.166 |
| 3 | I | R | M | T | S | L | 1.61 | 0.166 |
| 4 | I | R | M | A | S | F | 0.61 | 0.166 |
| 5 | N | R | M | A | N | L | 0.23 | 0.249 |
| 6 | I | R | T | A | S | L | 0.23 | 0.166 |
| 7 | I | S | M | A | S | L | 0.15 | 0.166 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2A12.aApr07-unspliced | main_exon | CDS | chr7 | 144,095,108 | 144,096,037 | + |
| 3UTR | chr7 | 144,096,037 | 144,096,040 | + | ||