OR2A14 Olfactory Receptor
| Gene Symbol | OR2A141 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 1 (pseudogene) |
| Aliases | OST182, OR7-12, HsOR7.6.15 |
| External Ids | HGNC: 15084 GeneBank: AB065693, AF399596, BK004421, NM_001001659 |
| Build #39 labels | OR2A14P, OR2A6 |
| Chromosomal location | 7:144,129,113-144,130,042 (+) |
| Cluster | 7@144 |
| Synteny | CLIC#16 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2A12 | 74.68% | 308 |
| OR2A2 | 77.27% | 308 |
| OR2A5 | 79.29% | 309 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2A5 | 79% | 308 |
| Mouse | Or2a14 | 83% | 308 |
| Rat | Or2a14 | 83% | 308 |
| Cow | OR2A5 | 80% | 309 |
| Cow | OR2A14B | 80% | 308 |
| Orang | OR2A2P | 78% | 308 |
| Horse | OR2A14C | 81% | 308 |
| Chimp | OR2A5 | 79% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136889 |
Sequence information
| Nucleotide sequence |
ATGGAAGGCAACAAGACATGGATCACAGACATCACCTTGCCGCGATTCCAGGTTGGTCCA GCACTGGAGATTCTCCTCTGTGGACTTTTCTCTGCCTTCTATACACTCACCCTGCTGGGG AATGGGGTCATCTTTGGGATTATCTGCCTGGACTGTAAGCTTCACACACCCATGTACTTC TTCCTCTCACACCTGGCCATTGTTGACATATCCTATGCTTCCAACTATGTCCCCAAGATG CTGACGAATCTTATGAACCAGGAAAGCACCATCTCCTTTTTTCCATGCATAATGCAGACA TTCTTGTATTTGGCTTTTGCTCACGTAGAGTGTCTGATTTTGGTGGTGATGTCCTATGAT CGCTATGCGGACATCTGCCACCCCTTACGTTACAATAGCCTCATGAGCTGGAGAGTGTGC ACTGTCCTGGCTGTGGCTTCCTGGGTGTTCAGCTTCCTCCTGGCTCTGGTCCCTTTAGTT CTCATCCTGAGCCTGCCCTTCTGCGGGCCTCATGAAATCAACCACTTCTTCTGTGAAATC CTGTCTGTCCTCAAGTTGGCCTGTGCTGACACCTGGCTCAACCAGGTGGTCATCTTTGCA GCCTGCGTGTTCATCCTGGTGGGGCCACTCTGCCTGGTGCTGGTCTCCTACTTGCGCATC CTGGCCGCCATCTTGAGGATCCAGTCTGGGGAGGGCCGCAGAAAGGCCTTCTCCACCTGC TCCTCCCACCTTTGCGTGGTGGGACTCTTCTTTGGCAGCGCCATTGTCACGTACATGGCC CCCAAGTCCCGCCATCCTGAGGAGCAGCAGAAAGTTCTTTCCCTGTTTTACAGCCTTTTC AATCCAATGCTGAACCCCCTGATATATAGCCTAAGGAATGCAGAGGTCAAGGGCGCCCTG AGGAGGGCACTGAGGAAGGAGAGGCTGACG |
| Conceptual translation |
MEGNKTWITDITLPRFQVGPALEILLCGLFSAFYTLTLLGNGVIFGIICLDCKLHTPMYF FLSHLAIVDISYASNYVPKMLTNLMNQESTISFFPCIMQTFLYLAFAHVECLILVVMSYD RYADICHPLRYNSLMSWRVCTVLAVASWVFSFLLALVPLVLILSLPFCGPHEINHFFCEI LSVLKLACADTWLNQVVIFAACVFILVGPLCLVLVSYLRILAAILRIQSGEGRRKAFSTC SSHLCVVGLFFGSAIVTYMAPKSRHPEEQQKVLSLFYSLFNPMLNPLIYSLRNAEVKGAL RRALRKERLT Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 7 | 143,826,730 | 143,826,732 | Del(3) | -/CTT | rs66549240 (DbSNP) | |
| 7 | 143,826,735 | 143,826,737 | Del(3) | -/TCT | rs34602346 (DbSNP) | |
| 7 | 143,826,980 | 143,826,980 | NS | A/G | M/V | rs59781893 (DbSNP) |
| 7 | 143,826,697 | 143,826,697 | NS | C/G | S/R | rs2961161 (DbSNP) |
| 7 | 143,826,603 | 143,826,603 | NS | G/T | S/I | rs2961160 (DbSNP) |
| 7 | 144,129,510 | 144,129,510 | NS | G/T | S/I | 1000GP (CEU, CHBJPT) |
| 7 | 144,129,604 | 144,129,604 | NS | C/G | S/R | 1000GP (CEU, CHBJPT) |
| 7 | 100 | -100 | NS | G/T | S/I | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 7 | 143,147,775 | 144,368,638 | CopyNumber | Variation_3708 (DGV) |
| 7 | 143,742,520 | 143,847,474 | CopyNumber | Variation_4570 (DGV) |
| 7 | 143,572,286 | 143,866,532 | CopyNumber | Variation_8581 (DGV) |
| 7 | 143,217,296 | 144,074,520 | CopyNumber | Variation_32962 (DGV) |
| 7 | 143,545,719 | 143,874,190 | CopyNumber | Variation_53583 (DGV) |
| CopyNumber | 57 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| P57S | S133I | P158H | S164R | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | P | I | P | R | 61.37 | 1.000 |
| 2 | P | S | P | S | 36.10 | 1.000 |
| 3 | P | S | P | R | 1.77 | 1.000 |
| 4 | P | I | H | R | 0.46 | 1.000 |
| 5 | S | I | P | R | 0.31 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2A14.aApr07-unspliced | main_exon | CDS | chr7 | 144,129,113 | 144,130,042 | + |
| 3UTR | chr7 | 144,130,042 | 144,130,045 | + | ||