OR2A2 Olfactory Receptor
| Gene Symbol | OR2A21 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.01 (functional) |
| Aliases | OR7-11, OST008, HsOR7.6.13 |
| External Ids | HGNC: 8230 GeneBank: AB065695, AF399459, BK004420, NM_001005480, XM_499490 |
| Build #39 labels | OR2A2, OR2A17P, OR2A2P |
| Chromosomal location | 7:144,109,583-144,110,536 (+) |
| Cluster | 7@144 |
| Synteny | CLIC#16 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2A13P | 84.36% | 307 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2A13 | 78% | 307 |
| Mouse | Or2a14 | 75% | 310 |
| Rat | Or2a14 | 75% | 310 |
| Cow | OR2A14 | 75% | 310 |
| Orang | OR2A2P | 97% | 313 |
| Horse | OR2A72 | 79% | 308 |
| Chimp | OR2A13 | 85% | 310 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136742 |
Sequence information
| Nucleotide sequence |
ATGGAAGGCAACCAGACATGGATCACAGACATCACCCTGCTGGGATTCCAGGTTGGTCCA GCACTGGCGATTCTCCTCTGTGGACTCTTCTCTGTCTTCTATACACTCACCCTGCTGGGG AATGGGGTCATCTTTGGGATTATCTGCCTGGACTCTAAGCTTCACACACCCATGTACTTC TTCCTCTCACACCTGGCCATCATTGACATGTCCTATGCTTCCAACAATGTTCCCAAGATG TTGGCAAACCTAATGAACCAGAAAAGAACCATCTCCTTTGTTCCATGCATAATGCAGACT TTTTTGTATTTGGCTTTTGCTGTTACAGAGTGCCTGATTTTGGTGGTGATGTCCTATGAT AGGTATGTGGCCATCTGCCACCCTTTCCAGTACACTGTCATCATGAGCTGGAGAGTGTGC ACGATCCTGGTTCTCACGTCCTGGTCATGTGGGTTTGCCCTGTCCCTGGTACATGAAATT CTCCTTCTAAGGTTGCCCTTCTGTGGGCCCCGGGATGTGAACCACCTCTTCTGTGAAATT CTGTCTGTCCTCAAGCTGGCCTGTGCTGACACCTGGGTTAACCAAGTGGTCATATTTGCT ACCTGTGTGTTTGTCTTAGTCGGGCCTCTTTCCTTGATTCTGGTCTCCTACATGCACATC CTCGGGGCCATCCTGAAGATCCAGACAAAGGAGGGCCGCATAAAGGCCTTCTCCACCTGC TCCTCCCACCTGTGTGTGGTTGGACTATTCTTTGGCATAGCCATGGTGGTTTACATGGTC CCAGACTCTAATCAACGAGAGGAGCAGGAGAAAATGCTGTCCCTGTTTCACAGTGTCTTT AATCCAATGCTGAACCCCCTGATCTACAGCCTGAGGAATGCTCAGTTGAAGGGCGCCCTC CACAGAGCACTCCAGAGGAAGAGGTCCATGAGAACGGTGTATGGGCTTTGCCTT |
| Conceptual translation |
MEGNQTWITDITLLGFQVGPALAILLCGLFSVFYTLTLLGNGVIFGIICLDSKLHTPMYF FLSHLAIIDMSYASNNVPKMLANLMNQKRTISFVPCIMQTFLYLAFAVTECLILVVMSYD RYVAICHPFQYTVIMSWRVCTILVLTSWSCGFALSLVHEILLLRLPFCGPRDVNHLFCEI LSVLKLACADTWVNQVVIFATCVFVLVGPLSLILVSYMHILGAILKIQTKEGRIKAFSTC SSHLCVVGLFFGIAMVVYMVPDSNQREEQEKMLSLFHSVFNPMLNPLIYSLRNAQLKGAL HRALQRKRSMRTVYGLCL Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 7 | 143,806,688 | 143,806,688 | NS | A/C | K/Q | rs10230228 (DbSNP) |
| 7 | 143,806,934 | 143,806,934 | NS | A/C | K/Q | rs61734798 (DbSNP) |
| 7 | 143,806,977 | 143,806,977 | NS | A/T | Y/F | rs61734817 (DbSNP) |
| 7 | 143,806,955 | 143,806,955 | NS | C/G | L/V | rs61729718 (DbSNP) |
| 7 | 143,806,987 | 143,806,987 | NS | C/G | F/L | rs61734820 (DbSNP) |
| 7 | 143,807,112 | 143,807,112 | NS | C/G | T/R | rs61735905 (DbSNP) |
| 7 | 143,806,998 | 143,806,998 | NS | C/T | A/V | rs61734823 (DbSNP) |
| 7 | 143,807,186 | 143,807,186 | NS | C/T | R/W | rs73728207 (DbSNP) |
| 7 | 143,807,304 | 143,807,304 | NS | C/T | P/L | rs10252253 (DbSNP) |
| 7 | 143,806,930 | 143,806,930 | NS | G/A | M/I | rs72503054 (DbSNP) |
| 7 | 143,806,988 | 143,806,988 | NS | G/T | A/S | rs61734821 (DbSNP) |
| 7 | 143,807,515 | 143,807,515 | NS | G/T | L/F | rs2961149 (DbSNP) |
| 7 | 143,806,927 | 143,806,927 | SYN | A/G | L/L | rs2684428 (DbSNP) |
| 7 | 143,806,924 | 143,806,924 | SYN | C/T | N/N | rs2684427 (DbSNP) |
| 7 | 143,807,008 | 143,807,008 | SYN | C/T | C/C | rs61734829 (DbSNP) |
| 7 | 143,807,518 | 143,807,518 | SYN | C/T | N/N | rs2951315 (DbSNP) |
| 7 | 144,110,476 | 144,110,476 | SYN | C/T | G/G | 1000GP (CEU) |
| 7 | 144,109,595 | 144,109,595 | NS | C/A | Q/K | 1000GP (CEU) |
| 7 | 144,110,422 | 144,110,422 | NS | T/G | F/L | 1000GP (CEU) |
| 7 | 144,110,425 | 144,110,425 | SYN | T/C | N/N | 1000GP (CEU) |
| 7 | 144,110,211 | 144,110,211 | NS | T/C | L/P | 1000GP (CEU) |
| 7 | 100 | -100 | NS | C/A | Q/K | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 7 | 100 | -100 | SYN | T/C | N/N | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 7 | 143,147,775 | 144,368,638 | CopyNumber | Variation_3708 (DGV) |
| 7 | 143,742,520 | 143,847,474 | CopyNumber | Variation_4570 (DGV) |
| 7 | 143,572,286 | 143,866,532 | CopyNumber | Variation_8581 (DGV) |
| 7 | 143,217,296 | 144,074,520 | CopyNumber | Variation_32962 (DGV) |
| 7 | 143,545,719 | 143,874,190 | CopyNumber | Variation_53583 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| Q5K | I68F | R89G | T146R | L210P | V260D | F280L | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Q | I | R | T | L | V | L | 42.24 | 0.013 |
| 2 | Q | I | R | T | L | V | F | 39.17 | 0.013 |
| 3 | K | I | R | T | P | V | F | 13.82 | 0.013 |
| 4 | K | I | R | R | P | V | F | 1.46 | 0.013 |
| 5 | K | F | R | T | P | V | F | 1.08 | 0.013 |
| 6 | K | I | G | T | P | V | F | 0.84 | 0.013 |
| 7 | Q | I | R | T | L | D | L | 0.54 | 0.013 |
| 8 | Q | I | R | T | P | V | F | 0.38 | 0.013 |
| 9 | Q | I | R | T | L | D | F | 0.38 | 0.013 |
| 10 | Q | I | R | R | L | V | L | 0.08 | 0.013 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2A2.aApr07-unspliced | main_exon | CDS | chr7 | 144,109,583 | 144,110,536 | + |
| 3UTR | chr7 | 144,110,536 | 144,110,539 | + | ||