OR2AE1 Olfactory Receptor
| Gene Symbol | OR2AE11 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | AE |
| Pseudogene | No |
| CORP pseudogene probability score | 0.62 (pseudogene) |
| Aliases | HsOR7.4.1, ORL3171 |
| External Ids | HGNC: 15087 GeneBank: AB065478, NM_001005276, XM_499460 ORDB: ORL3171 |
| Build #39 labels | OR2AE1 |
| Chromosomal location | 7:99,876,065-99,877,033 (-) |
| Cluster | 7@99 |
| Synteny | CLIC#0 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2M2 | 51.99% | 302 |
| OR2M5 | 51.66% | 302 |
| OR2M7 | 51.32% | 302 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2T26 | 54% | 306 |
| Mouse | Or2t45 | 54% | 309 |
| Rat | Or2ae2-ps | 71% | 286 |
| Cow | OR2M4 | 53% | 317 |
| Orang | OR2AJ1 | 52% | 312 |
| Horse | OR2AE1B | 81% | 322 |
| Horse | OR2AE1DP | 83% | 316 |
| Horse | OR2AE1EP | 82% | 308 |
| Chimp | OR2AJ1 | 51% | 312 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | DT932730 |
| mRNA | BC137376 |
| GNF Atlas2 | gnf1h11267_at |
Sequence information
| Nucleotide sequence |
ATGTGGCAGAAGAATCAGACCTCTCTGGCAGACTTCATCCTTGAGGGGCTCTTCGATGAC TCCCTTACCCACCTTTTCCTTTTCTCCTTGACCATGGTGGTCTTCCTTATTGCGGTGAGT GGCAACACCCTCACCATTCTCCTCATCTGCATTGATCCCCAGCTTCATACACCAATGTAT TTCCTGCTCAGCCAGCTCTCCCTCATGGATCTGATGCATGTCTCCACAATCATCCTGAAG ATGGCTACCAACTACCTATCTGGCAAGAAATCTATCTCCTTTGTGGGCTGTGCAACCCAG CACTTCCTCTATTTGTGTCTAGGTGGTGCTGAATGTTTTCTCTTAGCTGTCATGTCCTAT GACCGCTATGTTGCCATCTGTCATCCACTGCGCTATGCTGTGCTCATGAACAAGAAGGTG GGACTGATGATGGCTGTCATGTCATGGTTGGGGGCATCCGTGAACTCCCTAATTCACATG GCGATCTTGATGCACTTCCCTTTCTGTGGGCCTCGGAAAGTCTACCACTTCTACTGTGAG TTCCCAGCTGTTGTGAAGTTGGTATGTGGCGACATCACTGTGTATGAGACCACAGTGTAC ATCAGCAGCATTCTCCTCCTCCTCCCCATCTTCCTGATTTCTACATCCTATGTCTTCATC CTTCAAAGTGTCATTCAGATGCGCTCATCTGGGAGCAAGAGAAATGCCTTTGCCACTTGT GGCTCCCACCTCACGGTGGTTTCTCTTTGGTTTGGTGCCTGCATCTTCTCCTACATGAGA CCCAGGTCCCAGTGCACTCTATTGCAGAACAAAGTTGGTTCTGTGTTCTACAGCATCATT ACGCCCACATTGAATTCTCTGATTTATACTCTCCGGAATAAAGATGTAGCTAAGGCTCTG AGAAGAGTGCTGAGGAGAGATGTTATCACCCAGTGCATTCAACGACTGCAATTGTGGTTG CCCCGAGTG |
| Conceptual translation |
MWQKNQTSLADFILEGLFDDSLTHLFLFSLTMVVFLIAVSGNTLTILLICIDPQLHTPMY FLLSQLSLMDLMHVSTIILKMATNYLSGKKSISFVGCATQHFLYLCLGGAECFLLAVMSY DRYVAICHPLRYAVLMNKKVGLMMAVMSWLGASVNSLIHMAILMHFPFCGPRKVYHFYCE FPAVVKLVCGDITVYETTVYISSILLLLPIFLISTSYVFILQSVIQMRSSGSKRNAFATC GSHLTVVSLWFGACIFSYMRPRSQCTLLQNKVGSVFYSIITPTLNSLIYTLRNKDVAKAL RRVLRRDVITQCIQRLQLWLPRV Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 7 | 100 | -100 | NS | A/G | S/P | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 7 | 99,473,801 | 99,473,801 | NS | A/G | S/P | rs73403577 (DbSNP) |
| 7 | 99,473,858 | 99,473,858 | NS | C/G | V/L | rs17161997 (DbSNP) |
| 7 | 99,474,007 | 99,474,007 | NS | C/T | C/Y | rs60737583 (DbSNP) |
| 7 | 99,474,195 | 99,474,195 | SYN | A/C | V/V | rs62474462 (DbSNP) |
| 7 | 99,474,373 | 99,474,373 | NS | G/A | A/V | rs2164225 (DbSNP) |
| 7 | 99,474,427 | 99,474,427 | NS | G/A | T/I | rs2572023 (DbSNP) |
| 7 | 99,876,235 | 99,876,235 | NS | G/C | L/V | 1000GP (CEU) |
| 7 | 99,876,804 | 99,876,804 | NS | A/G | I/T | 1000GP (CEU, CHBJPT) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 7 | 99,471,688 | 99,474,756 | CopyNumber | #42 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| S286P | L267V | Y217C | S214F | R172W | P167T | I77T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | S | L | Y | S | R | P | I | 45.85 | 0.840 |
| 2 | S | L | Y | S | R | P | T | 33.03 | 0.840 |
| 3 | S | V | Y | S | R | P | T | 12.98 | 0.840 |
| 4 | P | L | C | S | R | P | T | 5.45 | 1.000 |
| 5 | P | L | C | S | W | T | T | 1.38 | 1.000 |
| 6 | P | L | C | S | W | P | T | 0.61 | 1.000 |
| 7 | S | L | Y | F | R | P | T | 0.54 | 0.840 |
| 8 | S | V | Y | S | R | P | I | 0.08 | 0.840 |
| 9 | S | L | Y | S | W | P | I | 0.08 | 0.840 |