OR2AK2 Olfactory Receptor
| Gene Symbol | OR2AK21 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | AK |
| Pseudogene | No |
| CORP pseudogene probability score | 0.07 (functional) |
| Aliases | OR1-47, HsOR1.5.19 |
| External Ids | HGNC: 19569 GeneBank: AB065951, BK004457, NM_001004491 |
| Build #39 labels | OR2AK2, OR2AK1P |
| Chromosomal location | 1:247,965,377-247,966,336 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2L3 | 58.22% | 304 |
| OR2L8 | 57.89% | 304 |
| OR2T27 | 54.9% | 306 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2AK3 | 78% | 284 |
| Mouse | Or2ak5 | 76% | 306 |
| Rat | Or2ak5-ps | 77% | 306 |
| Cow | OR2AK3 | 78% | 313 |
| Orang | OR2L3 | 58% | 304 |
| Horse | OR2L5 | 57% | 305 |
| Chimp | OR2L3 | 59% | 304 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | CR747362 |
| mRNA | BC136816 |
Sequence information
| Nucleotide sequence |
ATGAAAACAGGAAATCAAAGTTTTGGGACAGATTTTCTACTTGTTGGTCTTTTCCAATAT GGCTGGATAAACTCTCTTCTCTTTGTCGTCATTGCCACCCTCTTTACAGTTGCTCTGACA GGAAATATCATGCTGATCCACCTCATTCGACTGAACACCAGACTCCACACTCCAATGTAC TTTCTGCTCAGTCAGCTCTCCATCGTTGACCTCATGTACATCTCCACCACAGTGCCCAAG ATGGCAGTCAGCTTCCTCTCACAGAGTAAGACCATTAGATTTTTGGGCTGTGAGATTCAA ACGTATGTGTTCTTGGCCCTTGGTGGAACTGAAGCCCTTCTCCTTGGTTTTATGTCTTAT GATCGCTATGTAGCTATCTGTCACCCTTTACATTATCCTATGCTTATGAGCAAGAAGATC TGCTGCCTCATGGTTGCATGTGCATGGGCCAGTGGTTCTATCAATGCTTTCATACATACA TTGTATGTGTTTCAGCTTCCATTCTGTAGGTCTCGGCTCATTAACCACTTTTTCTGTGAA GTTCCAGCTCTACTATCATTGGTGTGTCAGGACACCTCCCAGTATGAGTATACAGTCCTC CTGAGTGGACTTATTATCTTGCTACTACCATTCCTAGCCATTCTGGCTTCCTATGCTCGT GTGCTTATTGTGGTATTCCAGATGAGCTCAGGAAAAGGACAGGCAAAAGCTGTTTCCACT TGTTCCTCCCACCTGATTGTGGCAAGCCTGTTCTATGCAACCACTCTCTTTACCTACACA AGGCCACACTCCTTGCGTTCCCCTTCACGGGATAAGGCGGTGGCAGTATTTTACACCATT GTCACACCTCTACTGAACCCATTTATCTACAGCCTGAGAAATAAGGAAGTGACGGGGGCA GTGAGGAGACTGTTGGGATATTGGATATGCTGTAGAAAATATGACTTCAGATCTCTGTAT |
| Conceptual translation |
MKTGNQSFGTDFLLVGLFQYGWINSLLFVVIATLFTVALTGNIMLIHLIRLNTRLHTPMY FLLSQLSIVDLMYISTTVPKMAVSFLSQSKTIRFLGCEIQTYVFLALGGTEALLLGFMSY DRYVAICHPLHYPMLMSKKICCLMVACAWASGSINAFIHTLYVFQLPFCRSRLINHFFCE VPALLSLVCQDTSQYEYTVLLSGLIILLLPFLAILASYARVLIVVFQMSSGKGQAKAVST CSSHLIVASLFYATTLFTYTRPHSLRSPSRDKAVAVFYTIVTPLLNPFIYSLRNKEVTGA VRRLLGYWICCRKYDFRSLY Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 100 | -100 | NS | T/C | V/A | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 1 | 100 | -100 | SYN | G/T | L/L | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 1 | 247,965,420 | 247,965,420 | NS | T/C | V/A | 1000GP (CEU, CHBJPT) |
| 1 | 247,965,627 | 247,965,627 | NS | G/A | S/N | 1000GP (CEU, CHBJPT) |
| 1 | 247,965,718 | 247,965,718 | SYN | C/T | L/L | 1000GP (CEU, CHBJPT) |
| 1 | 247,965,865 | 247,965,865 | SYN | G/A | V/V | 1000GP (CEU) |
| 1 | 247,965,938 | 247,965,938 | NS | G/A | V/M | 1000GP (CEU, CHBJPT) |
| 1 | 247,966,184 | 247,966,184 | NS | C/T | R/W | 1000GP (CEU, CHBJPT) |
| 1 | 248,128,722 | 248,128,722 | NS | C/T | A/V | rs41304159 (DbSNP) |
| 1 | 248,128,725 | 248,128,725 | NS | A/G | D/G | rs74153215 (DbSNP) |
| 1 | 248,128,929 | 248,128,929 | NS | A/G | N/S | rs6664332 (DbSNP) |
| 1 | 248,128,981 | 248,128,981 | SYN | A/G | T/T | rs74153216 (DbSNP) |
| 1 | 248,129,020 | 248,129,020 | SYN | C/T | L/L | rs41308168 (DbSNP) |
| 1 | 248,129,167 | 248,129,167 | SYN | A/G | V/V | rs41308166 (DbSNP) |
| 1 | 248,129,173 | 248,129,173 | SYN | A/G | Q/Q | rs74153217 (DbSNP) |
| 1 | 248,129,195 | 248,129,195 | NS | C/T | L/F | rs74153218 (DbSNP) |
| 1 | 248,129,240 | 248,129,240 | NS | A/G | M/V | rs4478844 (DbSNP) |
| 1 | 248,129,302 | 248,129,302 | SYN | A/G | L/L | rs74153219 (DbSNP) |
| 1 | 248,129,486 | 248,129,486 | NS | C/T | R/W | rs74153220 (DbSNP) |
| 1 | 248,129,501 | 248,129,501 | NS | A/G | T/A | rs74153221 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
| 1 | 248,128,962 | 248,129,289 | InDel | Variation_33212 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| V15A | G16D | S84N | Y102F | T160A | L173F | V188M | R270W | A275T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | V | G | S | Y | T | L | M | R | A | 43.01 | 0.177 |
| 2 | V | G | N | Y | T | L | V | R | A | 31.11 | 0.177 |
| 3 | V | G | S | Y | T | L | V | R | A | 20.28 | 0.177 |
| 4 | A | G | N | Y | T | L | V | W | A | 3.30 | 0.177 |
| 5 | V | G | N | Y | T | L | V | W | A | 1.00 | 0.177 |
| 6 | V | D | N | Y | T | F | V | R | T | 0.54 | 0.177 |
| 7 | V | G | S | F | T | L | V | R | A | 0.46 | 0.177 |
| 8 | V | G | N | Y | T | L | M | R | A | 0.15 | 0.177 |
| 9 | A | G | S | Y | T | L | M | W | A | 0.08 | 0.177 |
| 10 | V | G | S | Y | A | L | M | R | A | 0.08 | 0.177 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2AK2.aApr07-unspliced | main_exon | 5UTR | chr1 | 247,965,332 | 247,965,377 | + |
| CDS | chr1 | 247,965,377 | 247,966,336 | + | ||
| 3UTR | chr1 | 247,966,336 | 247,966,339 | + | ||