OR2B6 Olfactory Receptor
| Gene Symbol | OR2B61 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.25 (functional) |
| Aliases | OR5-40, OR5-41, OR6-4, OR6-31, HsOR6.2.3, ORL271 |
| External Ids | HGNC: 8241 GeneBank: BK004373, NM_012367, U86270, U86271, U86275 ORDB: ORL271 |
| Build #39 labels | OR2B6, OR2B1 |
| Chromosomal location | 6:27,957,241-27,958,179 (+) |
| Cluster | 6@28a |
| Synteny | CLIC#12 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2B2 | 81.61% | 310 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2B2 | 82% | 313 |
| Mouse | Or2b6 | 81% | 313 |
| Mouse | Or2b2b | 81% | 313 |
| Mouse | Or2b2 | 81% | 313 |
| Rat | Or2b2 | 78% | 313 |
| Cow | OR2B2 | 82% | 313 |
| Cow | OR2B2D | 82% | 314 |
| Orang | OR2B3 | 71% | 288 |
| Horse | OR2B2 | 83% | 312 |
| Chimp | OR2B2P | 82% | 313 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC109251 |
| GNF Atlas2 | 216522_at |
Sequence information
| Nucleotide sequence |
ATGAATTGGGTAAATGACAGCATCATACAGGAGTTTATTCTGCTGGGTTTCTCAGATCGA CCTTGGCTGGAGTTTCCACTCCTTGTGGTCTTCTTGATTTCTTACACTGTGACCATCTTT GGCAATCTGACCATTATTCTAGTGTCACGCCTGGACACCAAACTTCATACCCCCATGTAT TTTTTTCTTACCAATCTATCACTCCTGGATCTTTGTTACACCACATGTACAGTCCCACAA ATGCTAGTAAATTTATGCAGCATCAGGAAAGTAATCAGTTATCGTGGCTGTGTAGCCCAG CTTTTCATATTTCTGGCCTTGGGGGCTACTGAATATCTTCTCCTGGCCGTCATGTCCTTT GATAGGTTTGTAGCTATTTGTCGGCCTCTCCATTACTCAGTTATCATGCACCAGAGACTC TGCCTCCAGTTGGCAGCTGCATCCTGGGTTACTGGTTTTAGTAACTCAGTGTGGTTGTCT ACCCTGACTCTCCAGCTGCCACTCTGTGACCCCTATGTGATAGATCACTTTCTCTGTGAA GTCCCTGCACTGCTCAAGTTATCTTGTGTTGAGACAACAGCAAATGAGGCTGAACTATTC CTTGTCAGTGAGCTCTTCCATCTAATACCCCTGACACTCATCCTTATATCATATGCTTTT ATTGTCCGAGCAGTATTGAGGATACAGTCTGCTGAAGGTCGACAAAAAGCATTTGGGACA TGTGGTTCCCATCTAATTGTGGTGTCTCTTTTTTATAGTACAGCCGTCTCTGTGTACCTG CAACCACCTTCGCCCAGCTCCAAGGACCAAGGAAAGATGGTTTCTCTCTTCTATGGAATC ATTGCACCCATGCTGAATCCCCTTATATATACACTTAGGAACAAGGAGGTAAAGGAAGGC TTTAAAAGGTTGGTTGCAAGAGTCTTCTTAATCAAGAAA |
| Conceptual translation |
MNWVNDSIIQEFILLGFSDRPWLEFPLLVVFLISYTVTIFGNLTIILVSRLDTKLHTPMY FFLTNLSLLDLCYTTCTVPQMLVNLCSIRKVISYRGCVAQLFIFLALGATEYLLLAVMSF DRFVAICRPLHYSVIMHQRLCLQLAAASWVTGFSNSVWLSTLTLQLPLCDPYVIDHFLCE VPALLKLSCVETTANEAELFLVSELFHLIPLTLILISYAFIVRAVLRIQSAEGRQKAFGT CGSHLIVVSLFYSTAVSVYLQPPSPSSKDQGKMVSLFYGIIAPMLNPLIYTLRNKEVKEG FKRLVARVFLIKK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 6 | 27,925,367 | 27,925,367 | NS | A/G | I/V | rs7767176 (DbSNP) |
| 6 | 27,925,827 | 27,925,827 | NS | A/G | Q/R | rs9380030 (DbSNP) |
| 6 | 27,925,334 | 27,925,334 | NS | C/G | P/A | rs61739698 (DbSNP) |
| 6 | 27,925,255 | 27,925,255 | SYN | A/T | P/P | rs55711161 (DbSNP) |
| 6 | 27,925,456 | 27,925,456 | SYN | T/C | A/A | rs904142 (DbSNP) |
| 6 | 27,957,589 | 27,957,589 | NS | G/A | V/I | 1000GP (CEU) |
| 6 | 27,957,678 | 27,957,678 | SYN | T/C | A/A | 1000GP (CHBJPT) |
| 6 | 27,957,735 | 27,957,735 | NS | G/C | Q/H | 1000GP (CHBJPT) |
| 6 | 27,958,049 | 27,958,049 | NS | A/G | Q/R | 1000GP (CHBJPT) |
| 6 | 100 | -100 | SYN | A/T | P/P | 1000GP (YRI) |
| 6 | 100 | -100 | NS | G/A | V/I | 1000GP (YRI) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| V117I | I126V | E204V | Q270R | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | V | I | E | Q | 85.94 | 0.349 |
| 2 | I | I | E | Q | 7.68 | 0.349 |
| 3 | V | I | E | R | 4.76 | 0.349 |
| 4 | V | I | V | Q | 1.46 | 0.349 |
| 5 | V | V | V | Q | 0.08 | 0.349 |
| 6 | V | V | E | Q | 0.08 | 0.349 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| HIST1H2BOandOR2B6.aApr07-unspliced | main_exon | CDS | chr6 | 27,957,241 | 27,958,179 | + |
| 3UTR | chr6 | 27,958,179 | 27,958,189 | + | ||
| HIST1H2BOandOR2B6.bApr07 | exon_5UTR | chr6 | 27,893,425 | 27,893,981 | + | |
| main_exon | CDS_partial | chr6 | 27,957,999 | 27,958,179 | + | |
| 3UTR | chr6 | 27,958,179 | 27,958,322 | + | ||