OR2D2 Olfactory Receptor
| Gene Symbol | OR2D21 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | D |
| Pseudogene | No |
| CORP pseudogene probability score | 0.22 (functional) |
| Aliases | OR11-610, hg27, OR11-88, OR2D2, HsOR11.4.7, ORL3432, ORL483 |
| External Ids | HGNC: 8244 GeneBank: AB065824, AF065876, AF399591, BK004434, NM_003700 ORDB: ORL3432, ORL483 |
| Build #39 labels | OR2D2, OR2D1 |
| Chromosomal location | 11:6,891,577-6,892,500 (-) |
| Cluster | 11@7 |
| Synteny | CLIC#24 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2D3 | 63.84% | 307 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2D2C | 86% | 308 |
| Mouse | Or2d2 | 85% | 307 |
| Rat | Or2d2 | 85% | 307 |
| Rat | Or2d2b | 83% | 307 |
| Cow | OR2D3G | 66% | 307 |
| Orang | OR2D3P | 64% | 308 |
| Horse | OR2D2C | 83% | 308 |
| Horse | OR2D2DP | 80% | 308 |
| Chimp | OR2D3 | 64% | 308 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC140729 |
| GNF Atlas2 | gnf1h10962_at |
Sequence information
| Nucleotide sequence |
ATGAGACAGATAAATCAGACACAAGTGACAGAATTCCTCCTTCTGGGACTCTCTGATGGG CCACACACCGAGCAGCTGCTATTTATCGTATTATTGGGTGTCTACCTGGTCACTGTGCTT GGAAATCTGCTTCTAATCTCCCTTGTTCATGTTGACTCCCAACTTCACACACCCATGTAT TTTTTTCTCTGCAACTTGTCTCTGGCTGACCTCTGTTTCTCTACCAACATAGTTCCTCAG GCACTAGTCCACCTGCTTTCCAGAAAGAAGGTCATTGCATTCACACTTTGCGCAGCTCGA CTTCTCTTTTTCCTCATTTTTGGGTGTACCCAGTGCGCCCTTCTTGCAGTGATGTCCTAT GATCGCTATGTTGCAATCTGCAATCCTCTGCGTTACCCTAACATCATGACCTGGAAAGTG TGTGTCCAGCTGGCAACAGGATCATGGACCAGTGGCATTCTGGTGTCTGTGGTAGACACC ACCTTCATACTGAGGCTACCCTACCGAGGCAGTAACAGCATTGCTCATTTCTTTTGTGAG GCCCCTGCACTATTGATCTTAGCATCCACAGACACCCATGCATCAGAGATGGCCATTTTT CTTATGGGGGTTGTGATTCTCCTCATACCTGTTTTTCTGATTCTGGTATCCTATGGCCGT ATCATAGTAACTGTGGTCAAGATGAAGTCAACTGTGGGGAGTCTCAAGGCATTTTCTACC TGTGGCTCCCACCTCATGGTGGTCATACTTTTTTATGGATCAGCAATTATCACTTACATG ACACCCAAGTCTTCCAAACAGCAGGAAAAATCGGTGTCTGTTTTCTATGCAATAGTGACT CCCATGCTTAATCCCCTCATCTATAGCCTGAGAAACAAGGATGTGAAGGCAGCTCTGAGG AAAGTAGCCACAAGGAATTTCCCA |
| Conceptual translation |
MRQINQTQVTEFLLLGLSDGPHTEQLLFIVLLGVYLVTVLGNLLLISLVHVDSQLHTPMY FFLCNLSLADLCFSTNIVPQALVHLLSRKKVIAFTLCAARLLFFLIFGCTQCALLAVMSY DRYVAICNPLRYPNIMTWKVCVQLATGSWTSGILVSVVDTTFILRLPYRGSNSIAHFFCE APALLILASTDTHASEMAIFLMGVVILLIPVFLILVSYGRIIVTVVKMKSTVGSLKAFST CGSHLMVVILFYGSAIITYMTPKSSKQQEKSVSVFYAIVTPMLNPLIYSLRNKDVKAALR KVATRNFP Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 100 | -100 | nonsense SNP | G/T | C/* | 1000GP (YRI) |
| 11 | 100 | -100 | NS | A/G | M/T | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI) |
| 11 | 6,891,596 | 6,891,596 | NS | A/G | V/A | 1000GP (CEU) |
| 11 | 6,891,896 | 6,891,896 | NS | A/G | M/T | 1000GP (CEU, CHBJPT) |
| 11 | 6,892,012 | 6,892,012 | NS | T/C | I/M | 1000GP (CEU, CHBJPT) |
| 11 | 6,892,013 | 6,892,013 | NS | A/G | I/T | 1000GP (CEU, CHBJPT) |
| 11 | 6,892,050 | 6,892,050 | NS | T/C | S/G | 1000GP (CEU) |
| 11 | 6,892,059 | 6,892,059 | NS | A/G | S/P | 1000GP (CEU, CHBJPT) |
| 11 | 6,912,844 | 6,912,844 | SYN | C/T | K/K | rs71472615 (DbSNP) |
| 11 | 6,912,925 | 6,912,926 | Del(2) | -/TT | rs10566026 (DbSNP) | |
| 11 | 6,913,074 | 6,913,074 | NS | C/G | G/R | rs60116285 (DbSNP) |
| 11 | 6,913,127 | 6,913,127 | NS | G/A | T/M | rs2741804 (DbSNP) |
| 11 | 6,913,243 | 6,913,243 | NS | C/T | M/I | rs1965207 (DbSNP) |
| 11 | 6,913,244 | 6,913,244 | NS | A/G | I/T | rs1965208 (DbSNP) |
| 11 | 6,913,290 | 6,913,290 | NS | A/G | S/P | rs1965209 (DbSNP) |
| 11 | 6,913,399 | 6,913,399 | SYN | C/T | Q/Q | rs58942970 (DbSNP) |
| 11 | 6,913,482 | 6,913,482 | NS | A/G | Y/H | rs57896484 (DbSNP) |
| 11 | 6,913,540 | 6,913,540 | nonsense SNP | G/T | C/* | rs16919417 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 6,910,808 | 6,913,831 | CopyNumber | #124 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R220H | M202T | I163M | S151G | S148P | Y120S | H84Y | C64* | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | R | M | I | S | S | Y | H | C | 40.32 | 0.492 |
| 2 | R | T | I | S | S | Y | H | C | 26.27 | 0.492 |
| 3 | R | T | I | S | P | Y | H | C | 15.05 | 0.492 |
| 4 | R | M | M | S | S | Y | H | C | 13.13 | 0.492 |
| 5 | R | M | I | S | S | Y | Y | C | 2.30 | 0.492 |
| 6 | R | M | I | S | S | Y | H | * | 1.31 | 1.200 |
| 7 | R | M | I | S | S | S | H | C | 0.84 | 0.492 |
| 8 | H | M | I | S | S | Y | H | C | 0.46 | 0.492 |
| 9 | R | T | I | G | S | Y | H | C | 0.31 | 0.492 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2D2.aApr07-unspliced | main_exon | 3UTR | chr11 | 6,891,574 | 6,891,577 | - |
| CDS | chr11 | 6,891,577 | 6,892,500 | - | ||