OR2H1 Olfactory Receptor
| Gene Symbol | OR2H11 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | H |
| Pseudogene | No |
| CORP pseudogene probability score | 0.13 (functional) |
| Aliases | OLFR42A-9004-14, dJ994E9.4, OR6-2, hs6M1-16, OR6-32, OLFR42A, HsOR6.3.23, ORL675 |
| External Ids | HGNC: 8252 GeneBank: AF042073, AF042074, AF042078, AF044491-AF044493, BK004209, HSA302604-HSA302613, HSA459845-HSA459847 ORDB: ORL675 |
| Build #39 labels | OR2H1 |
| Chromosomal location | 6:29,461,770-29,462,717 (+) |
| Cluster | 6@29 |
| Synteny | CLIC#12 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2H2 | 86.86% | 312 |
| OR2H5P | 83.01% | 306 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2H9P | 72% | 311 |
| Mouse | Or2h1 | 85% | 312 |
| Mouse | Or2h2 | 84% | 306 |
| Rat | Or2h1 | 85% | 312 |
| Rat | Or2h2c | 85% | 312 |
| Rat | Or2h1b-ps | 83% | 313 |
| Rat | Or2h2 | 84% | 308 |
| Cow | OR2H1D | 83% | 312 |
| Orang | OR2H1P | 95% | 316 |
| Horse | OR2H1F | 86% | 317 |
| Horse | OR2H1E | 86% | 312 |
| Chimp | OR2H2P | 74% | 359 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | EL734021 |
| mRNA | HQ447990 |
| GNF Atlas2 | 216817_s_at |
Sequence information
| Nucleotide sequence |
ATGGTTAACCAAAGCTCCCCCATGGGCTTCCTCCTTCTGGGCTTCTCTGAACACCCAGCA CTGGAAAGGACTCTCTTTGTGGTTGTCTTCACTTCCTACCTCTTGACCCTGGTGGGCAAC ACACTCATCATCCTGCTGTCTGTACTGTACCCCAGGCTCCACTCTCCAATGTACTTTTTC CTCTCTGACCTCTCCTTCTTGGACCTCTGCTTTACCACAAGTTGTGTCCCCCAGATGCTG GTCAACCTCTGGGGCCCAAAGAAGACCATCAGCTTCCTGGGATGCTCTGTCCAGCTCTTC ATCTTCCTGTCCCTGGGGACCACTGAGTGCATCCTCCTGACAGTGATGGCCTTTGACCGA TACGTGGCTGTCTGCCAGCCCCTCCACTATGCCACCATCATCCACCCCCGCCTGTGCTGG CAGCTGGCATCTGTGGCCTGGGTTATGAGTCTGGTTCAATCGATAGTCCAGACACCATCC ACCCTCCACTTGCCCTTCTGTCCCCACCAGCAGATAGATGACTTTTTATGTGAGGTCCCA TCTCTGATTCGACTCTCCTGTGGAGATACCTCCTACAATGAAATCCAGTTGGCTGTGTCC AGTGTCATCTTCGTGGTTGTGCCTCTCAGCCTCATCCTTGCCTCTTATGGAGCCACTGCC CAGGCAGTGCTGAGGATTAACTCTGCCACAGCATGGAGAAAGGCCTTTGGGACCTGCTCC TCCCATCTCACTGTGGTCACCCTCTTCTACAGCTCAGTCATTGCTGTCTACCTCCAGCCC AAAAATCCGTATGCCCAAGGGAGGGGCAAGTTCTTTGGTCTCTTCTATGCAGTGGGCACT CCTTCACTTAACCCTCTCGTATACACCCTGAGGAACAAGGAGATAAAGCGAGCACTCAGG AGGTTACTAGGGAAGGAAAGAGACTCCAGGGAAAGCTGGAGAGCTGCT |
| Conceptual translation |
MVNQSSPMGFLLLGFSEHPALERTLFVVVFTSYLLTLVGNTLIILLSVLYPRLHSPMYFF LSDLSFLDLCFTTSCVPQMLVNLWGPKKTISFLGCSVQLFIFLSLGTTECILLTVMAFDR YVAVCQPLHYATIIHPRLCWQLASVAWVMSLVQSIVQTPSTLHLPFCPHQQIDDFLCEVP SLIRLSCGDTSYNEIQLAVSSVIFVVVPLSLILASYGATAQAVLRINSATAWRKAFGTCS SHLTVVTLFYSSVIAVYLQPKNPYAQGRGKFFGLFYAVGTPSLNPLVYTLRNKEIKRALR RLLGKERDSRESWRAA Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 6 | 29,430,213 | 29,430,213 | NS | A/G | M/V | rs17184086 (DbSNP) |
| 6 | 29,429,733 | 29,429,733 | NS | A/G | N/D | rs61732185 (DbSNP) |
| 6 | 29,430,344 | 29,430,344 | NS | A/T | Q/H | rs17177681 (DbSNP) |
| 6 | 29,429,551 | 29,429,551 | NS | G/T | G/V | rs61750048 (DbSNP) |
| 6 | 29,429,549 | 29,429,549 | NS | G/T | M/I | rs62408592 (DbSNP) |
| 6 | 29,429,765 | 29,429,765 | SYN | A/G | T/T | rs41271553 (DbSNP) |
| 6 | 29,429,642 | 29,429,642 | SYN | C/T | S/S | rs61752584 (DbSNP) |
| 6 | 29,429,732 | 29,429,732 | SYN | C/T | S/S | rs61732184 (DbSNP) |
| 6 | 29,430,170 | 29,430,170 | SYN | T/C | P/P | rs2073148 (DbSNP) |
| 6 | 29,462,436 | 29,462,436 | NS | G/A | V/M | 1000GP (CEU) |
| 6 | 29,462,393 | 29,462,393 | SYN | T/C | P/P | 1000GP (CEU, CHBJPT) |
| 6 | 29,461,988 | 29,461,988 | SYN | A/G | T/T | 1000GP (CEU) |
| 6 | 100 | -100 | SYN | C/T | S/S | 1000GP (YRI, YRI, YRI, YRI) |
| 6 | 100 | -100 | NS | G/A | M/I | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 33 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| M57I | D63N | L80P | V223M | Q266H | K270N | P281R | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | M | D | L | V | Q | K | P | 91.94 | 0.299 |
| 2 | M | N | L | V | Q | K | P | 3.99 | 0.299 |
| 3 | M | D | L | V | H | K | P | 1.46 | 0.299 |
| 4 | I | D | L | V | Q | K | P | 0.77 | 0.780 |
| 5 | M | D | L | M | Q | K | P | 0.61 | 0.589 |
| 6 | M | D | P | V | Q | K | P | 0.61 | 0.243 |
| 7 | M | D | L | V | Q | K | R | 0.38 | 0.444 |
| 8 | M | D | L | V | Q | N | P | 0.23 | 0.299 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2H1.aApr07 | exon_5UTR | chr6 | 29,458,453 | 29,458,569 | + | |
| exon_5UTR | chr6 | 29,460,404 | 29,460,454 | + | ||
| main_exon | 5UTR | chr6 | 29,461,499 | 29,461,770 | + | |
| CDS | chr6 | 29,461,770 | 29,462,717 | + | ||
| 3UTR | chr6 | 29,462,717 | 29,464,205 | + | ||
| OR2H1.bApr07 | exon_5UTR | chr6 | 29,457,180 | 29,457,207 | + | |
| exon_5UTR | chr6 | 29,458,454 | 29,458,569 | + | ||
| exon_5UTR | chr6 | 29,460,404 | 29,460,454 | + | ||
| main_exon | 5UTR | chr6 | 29,461,499 | 29,461,770 | + | |
| CDS | chr6 | 29,461,770 | 29,462,717 | + | ||
| 3UTR | chr6 | 29,462,717 | 29,462,733 | + | ||
| OR2H1.cApr07 | exon_5UTR | chr6 | 29,459,772 | 29,460,184 | + | |
| main_exon | 5UTR | chr6 | 29,461,475 | 29,461,770 | + | |
| CDS | chr6 | 29,461,770 | 29,462,717 | + | ||
| 3UTR | chr6 | 29,462,717 | 29,462,733 | + | ||
| exon_3UTR | chr6 | 29,463,749 | 29,464,328 | + | ||
| OR2H1.dApr07 | exon_5UTR | chr6 | 29,458,354 | 29,458,569 | + | |
| exon_5UTR | chr6 | 29,460,404 | 29,460,454 | + | ||
| main_exon | 5UTR | chr6 | 29,461,495 | 29,461,770 | + | |
| CDS | chr6 | 29,461,770 | 29,462,717 | + | ||
| 3UTR | chr6 | 29,462,717 | 29,464,320 | + | ||
| OR2H1.eApr07 | exon_5UTR | chr6 | 29,457,160 | 29,457,207 | + | |
| exon_5UTR | chr6 | 29,458,454 | 29,458,569 | + | ||
| exon_5UTR | chr6 | 29,459,275 | 29,459,369 | + | ||
| exon_5UTR | chr6 | 29,460,404 | 29,460,454 | + | ||
| exon_5UTR | chr6 | 29,461,495 | 29,461,750 | + | ||
| main_exon | CDS_partial | chr6 | 29,461,991 | 29,462,717 | + | |
| 3UTR | chr6 | 29,462,717 | 29,462,720 | + | ||
| OR2H1.fApr07 | exon_5UTR | chr6 | 29,458,559 | 29,458,569 | + | |
| exon_5UTR | chr6 | 29,460,404 | 29,460,454 | + | ||
| exon_5UTR | chr6 | 29,461,495 | 29,461,750 | + | ||
| main_exon | CDS_partial | chr6 | 29,462,004 | 29,462,717 | + | |
| 3UTR | chr6 | 29,462,717 | 29,462,720 | + | ||
| OR2H1.gApr07 | exon_5UTR | chr6 | 29,456,977 | 29,457,207 | + | |
| exon_5UTR | chr6 | 29,458,454 | 29,458,569 | + | ||
| main_exon | 5UTR | chr6 | 29,461,495 | 29,461,770 | + | |
| CDS_partial | chr6 | 29,461,770 | 29,461,900 | + | ||
| OR2H1.hApr07 | exon_5UTR | chr6 | 29,457,160 | 29,457,207 | + | |
| exon_5UTR | chr6 | 29,458,454 | 29,458,569 | + | ||
| exon_5UTR | chr6 | 29,460,404 | 29,460,454 | + | ||
| main_exon | 5UTR | chr6 | 29,461,495 | 29,461,770 | + | |
| CDS_partial | chr6 | 29,461,770 | 29,461,965 | + | ||