OR2L2 Olfactory Receptor
| Gene Symbol | OR2L21 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | L |
| Pseudogene | No |
| CORP pseudogene probability score | 0.01 (functional) |
| Aliases | OR1-48, HSHTPCRH07, HsOR1.5.24, ORL36 |
| External Ids | HGNC: 8266 GeneBank: AB065597, BK004752, HSHTPRH07, NM_001004686 ORDB: ORL36 |
| Build #39 labels | OR2L4P, OR2L2, OR2L12 |
| Chromosomal location | 1:248,038,268-248,039,203 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2L1P | 90.26% | 308 |
| OR2L5 | 90.06% | 312 |
| OR2L8 | 85.58% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2L5 | 82% | 312 |
| Dog | OR2L3B | 80% | 312 |
| Mouse | Or2l5 | 80% | 307 |
| Rat | Or2l5 | 79% | 307 |
| Cow | OR2L3 | 83% | 312 |
| Cow | OR2L2C | 81% | 312 |
| Cow | OR2L3C | 80% | 312 |
| Cow | OR2L2B | 80% | 312 |
| Orang | OR2L5 | 90% | 312 |
| Orang | OR2L1 | 88% | 312 |
| Horse | OR2L5 | 85% | 307 |
| Horse | OR2L5JP | 83% | 312 |
| Horse | OR2L5D | 83% | 307 |
| Chimp | OR2L1 | 90% | 312 |
| Chimp | OR2L5P | 89% | 311 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | X64978 |
Sequence information
| Nucleotide sequence |
ATGGAAAATTACAATCAAACATCAACTGATTTCATCTTATTGGGGCTGTTCCCACAATCA AGAATTGGCCTTTTCGTATTCACCCTCATTTTTCTCATTTTCCTAATGGCTCTAATTGGA AATCTATCCATGATTCTTCTCATCTTTTTGGACATCCATCTCCACACACCTATGTATTTC CTACTTAGTCAGCTCTCCCTCATTGACCTAAATTACATCTCCACCATTGTTCCAAAGATG GTTTATGATTTTCTGTATGGAAACAAGTCTATCTCCTTCACTGGATGTGGGATTCAGAGT TTCTTCTTCTTGACTTTAGCAGTTGCAGAAGGGCTGCTCCTGACATCAATGGCCTATGAT CGTTATGTGGCCATTTGCTTTCCTCTCCACTATCCCATCCGTATAAGCAAAAGAGTGTGT GTGATGATGATAACAGGATCTTGGATGATAAGCTCTATCAACTCTTGTGCTCACACAGTA TATGCACTCTGTATCCCATATTGCAAGTCCAGAGCCATCAATCATTTTTTCTGTGATGTT CCAGCTATGTTGACGCTAGCCTGCACAGACACTTGGGTCTATGAGAGCACAGTGTTTTTG AGCAGCACCATCTTTCTTGTGCTTCCTTTCACTGGTATTGCATGTTCCTATGGCCGGGTT CTCCTTGCTGTCTACCGCATGCACTCTGCAGAAGGGAGGAAGAAGGCCTATTCAACCTGT AGCACCCACCTCACTGTAGTGTCCTTCTACTATGCACCCTTTGCTTATACCTATGTACGT CCAAGATCCCTGCGATCTCCAACAGAGGACAAGATTCTGGCTGTTTTCTACACCATCCTC ACCCCAATGCTCAACCCCATCATCTACAGCCTGAGAAACAAGGAGGTGATGGGGGCCCTG ACACAAGTGATTCAGAAAATCTTCTCAGTGAAAATG |
| Conceptual translation |
MENYNQTSTDFILLGLFPQSRIGLFVFTLIFLIFLMALIGNLSMILLIFLDIHLHTPMYF LLSQLSLIDLNYISTIVPKMVYDFLYGNKSISFTGCGIQSFFFLTLAVAEGLLLTSMAYD RYVAICFPLHYPIRISKRVCVMMITGSWMISSINSCAHTVYALCIPYCKSRAINHFFCDV PAMLTLACTDTWVYESTVFLSSTIFLVLPFTGIACSYGRVLLAVYRMHSAEGRKKAYSTC STHLTVVSFYYAPFAYTYVRPRSLRSPTEDKILAVFYTILTPMLNPIIYSLRNKEVMGAL TQVIQKIFSVKM Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 248,202,316 | 248,202,316 | NS | C/G | F/L | rs12134979 (DbSNP) |
| 1 | 248,202,344 | 248,202,344 | NS | C/G | L/V | rs6658141 (DbSNP) |
| 1 | 248,201,892 | 248,201,892 | NS | G/T | G/V | rs73141397 (DbSNP) |
| 1 | 248,202,382 | 248,202,382 | SYN | A/G | K/K | rs6658161 (DbSNP) |
| 1 | 248,202,283 | 248,202,283 | SYN | A/G | S/S | rs73141398 (DbSNP) |
| 1 | 248,202,211 | 248,202,211 | SYN | A/G | A/A | rs56102617 (DbSNP) |
| 1 | 248,202,340 | 248,202,340 | SYN | C/G | T/T | rs12134981 (DbSNP) |
| 1 | 248,202,289 | 248,202,289 | SYN | C/T | C/C | rs72763251 (DbSNP) |
| 1 | 248,201,879 | 248,201,879 | SYN | C/T | L/L | rs73141396 (DbSNP) |
| 1 | 248,038,909 | 248,038,909 | SYN | A/G | A/A | 1000GP (CEU) |
| 1 | 248,039,042 | 248,039,042 | NS | G/C | V/L | 1000GP (CEU, CHBJPT) |
| 1 | 248,038,927 | 248,038,927 | SYN | T/C | V/V | 1000GP (CHBJPT) |
| 1 | 248,038,931 | 248,038,931 | NS | C/T | L/F | 1000GP (CHBJPT) |
| 1 | 248,038,993 | 248,038,993 | SYN | C/A | T/T | 1000GP (CHBJPT) |
| 1 | 100 | -100 | SYN | A/T | P/P | 1000GP (YRI, YRI, YRI, YRI) |
| 1 | 100 | -100 | NS | T/G | V/G | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
| 1 | 248,145,644 | 248,277,638 | CopyNumber | Variation_48304 (DGV) |
| 1 | 248,179,503 | 248,290,781 | CopyNumber | Variation_74987 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| C96Y | V108G | R121H | S202T | Y250C | V259L | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | C | V | R | S | Y | V | 62.83 | 0.027 |
| 2 | C | V | R | S | Y | L | 31.18 | 0.027 |
| 3 | C | G | R | S | Y | L | 2.61 | 0.027 |
| 4 | C | V | H | S | Y | L | 1.23 | 0.327 |
| 5 | C | V | R | T | Y | L | 1.15 | 0.027 |
| 6 | C | V | R | S | C | L | 0.46 | 0.036 |
| 7 | Y | V | R | T | Y | L | 0.46 | 0.691 |
| 8 | Y | V | R | S | Y | L | 0.08 | 0.691 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2L2.aApr07-unspliced | main_exon | 5UTR | chr1 | 248,038,172 | 248,038,268 | + |
| CDS | chr1 | 248,038,268 | 248,039,203 | + | ||
| 3UTR | chr1 | 248,039,203 | 248,039,305 | + | ||