OR2L3 Olfactory Receptor
| Gene Symbol | OR2L31 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | L |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | HsOR1.5.25, ORL3039 |
| External Ids | HGNC: 15009 GeneBank: AB065950, NM_001004687 ORDB: ORL3039 |
| Build #39 labels | OR2L3 |
| Chromosomal location | 1:248,060,682-248,061,617 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2L6P | 92.63% | 312 |
| OR2L8 | 95.51% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2L3B | 82% | 312 |
| Dog | OR2L5C | 81% | 312 |
| Dog | OR2L5 | 81% | 312 |
| Mouse | Or2l5 | 79% | 312 |
| Rat | Or2l5 | 79% | 312 |
| Cow | OR2L3C | 81% | 312 |
| Cow | OR2L2C | 80% | 312 |
| Orang | OR2L3D | 89% | 312 |
| Orang | OR2L5 | 88% | 312 |
| Horse | OR2L5JP | 84% | 312 |
| Horse | OR2L5 | 85% | 307 |
| Horse | OR2L5D | 84% | 307 |
| Chimp | OR2L3C | 95% | 312 |
| Chimp | OR2L6 | 93% | 312 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | EG357668 |
| mRNA | BC137040 |
Sequence information
| Nucleotide sequence |
ATGGAAAATTACAATCAAACATCAACTGATTTCATCTTATTAGGATTCTTCCCACCATCA AGAATTGGCCTTTTCCTCTTCATCCTCATTGTTTTCATTTTCCTAATGGCTCTAATTGGA AACCTATCCATGATTCTTCTCATCTTCTTGGACACCCATCTCCACACACCCATGTATTTC CTACTTAGTCAGCTCTCCCTCATTGACCTAAATTACATCTCCACCATTGTTCCTAAGATG GCATCTGATTTTCTGTCTGGTAACAAGTCTATCTCCTTCACTGGGTGTGGGATTCAGAGT TTCTTCTTCTCGGCATTAGGAGGTGCAGAAGCACTACTTTTGGCATCTATGGCCTATGAT CGTTACATTGCTATTTGCTTTCCTCTTCACTATCCCATCCGCATGAGCAAAAGAATGTGT GTGCTGATGATAACAGGGTCTTGGATCATAGGCTCGATCAATGCTTGTGCTCACACTGTA TATGTACTCCATATTCCTTATTGCCAATCCAGGGCCATCAATCATTTCTTCTGTGATGTC CCAGCAATGGTGACTCTGGCCTGCATGGACACCTGGGTCTATGAGGGCACAGTGTTTTTG AGCACCACCATCTTTCTCGTGTTTCCCTTCATTGCTATTTCATGTTCCTATGGCCGGGTT CTCCTTGCTGTCTACCACATGAAATCTGCAGAAGGGAGGAAGAAAGCCTACCTGACCTGC AGCACCCACCTCACTGTAGTAACTTTCTACTATGCACCTTTTGTCTACACTTATCTACGT CCAAGATCCCTGCGATCTCCAACAGAGGACAAGGTTCTGGCTGTCTTCTACACCACCCTC ACTCCAATGCTCAACCCCATCATCTATAGCCTGAGGAACAAGGAGGTGATGGGGGCCCTG ACACGAGTGAGTCAGAGAATCTGCTCTGGGAAAATG |
| Conceptual translation |
MENYNQTSTDFILLGFFPPSRIGLFLFILIVFIFLMALIGNLSMILLIFLDTHLHTPMYF LLSQLSLIDLNYISTIVPKMASDFLSGNKSISFTGCGIQSFFFSALGGAEALLLASMAYD RYIAICFPLHYPIRMSKRMCVLMITGSWIIGSINACAHTVYVLHIPYCQSRAINHFFCDV PAMVTLACMDTWVYEGTVFLSTTIFLVFPFIAISCSYGRVLLAVYHMKSAEGRKKAYLTC STHLTVVTFYYAPFVYTYLRPRSLRSPTEDKVLAVFYTTLTPMLNPIIYSLRNKEVMGAL TRVSQRICSGKM Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 248,224,587 | 248,224,587 | NS | A/G | T/A | rs61525219 (DbSNP) |
| 1 | 248,224,398 | 248,224,398 | NS | A/G | M/V | rs55937620 (DbSNP) |
| 1 | 248,224,489 | 248,224,489 | NS | A/G | Q/R | rs56834114 (DbSNP) |
| 1 | 248,224,578 | 248,224,578 | NS | C/T | L/F | rs60743763 (DbSNP) |
| 1 | 248,224,294 | 248,224,294 | NS | C/T | S/L | rs6658256 (DbSNP) |
| 1 | 248,224,099 | 248,224,099 | NS | C/T | T/I | rs6666048 (DbSNP) |
| 1 | 248,224,216 | 248,224,216 | NS | C/T | P/L | rs6658227 (DbSNP) |
| 1 | 248,224,746 | 248,224,746 | NS | G/T | V/F | rs6697812 (DbSNP) |
| 1 | 248,224,586 | 248,224,586 | SYN | C/T | S/S | rs60429598 (DbSNP) |
| 1 | 248,224,754 | 248,224,754 | SYN | C/T | T/T | rs55893924 (DbSNP) |
| 1 | 248,060,992 | 248,060,992 | NS | C/T | S/L | 1000GP (CEU) |
| 1 | 248,061,187 | 248,061,187 | NS | A/G | Q/R | 1000GP (CEU) |
| 1 | 248,061,096 | 248,061,096 | NS | A/G | M/V | 1000GP (CEU, CHBJPT) |
| 1 | 100 | -100 | NS | A/G | M/V | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
| 1 | 248,145,644 | 248,277,638 | CopyNumber | Variation_48304 (DGV) |
| 1 | 248,179,503 | 248,290,781 | CopyNumber | Variation_74987 (DGV) |
| 1 | 248,223,884 | 248,226,919 | CopyNumber | #29 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| P78L | S82P | S104L | M139V | A212G | A236V | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | P | S | S | M | A | A | 54.53 | 0.030 |
| 2 | L | S | L | V | A | A | 16.44 | 0.076 |
| 3 | P | S | S | M | G | A | 9.45 | 0.030 |
| 4 | P | S | L | M | A | A | 9.14 | 0.030 |
| 5 | P | S | L | M | G | A | 3.46 | 0.030 |
| 6 | L | S | L | V | G | A | 2.38 | 0.076 |
| 7 | L | S | L | M | A | A | 0.84 | 0.076 |
| 8 | L | S | S | V | A | A | 0.77 | 0.076 |
| 9 | P | S | S | M | A | V | 0.77 | 0.080 |
| 10 | L | S | S | M | A | A | 0.54 | 0.076 |
| 11 | L | S | S | V | G | A | 0.46 | 0.076 |
| 12 | P | S | S | V | A | A | 0.23 | 0.030 |
| 13 | L | P | L | V | A | A | 0.15 | 0.076 |
| 14 | P | S | S | M | G | V | 0.15 | 0.080 |
| 15 | L | S | L | M | G | A | 0.15 | 0.076 |
| 16 | P | S | S | V | G | A | 0.15 | 0.030 |
| 17 | L | P | S | V | A | A | 0.08 | 0.076 |
| 18 | L | S | S | M | G | A | 0.08 | 0.076 |
| 19 | P | S | L | V | G | A | 0.08 | 0.030 |
| 20 | L | P | L | M | A | A | 0.08 | 0.076 |
| 21 | L | P | S | M | A | A | 0.08 | 0.076 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2L3.aApr07-unspliced | main_exon | CDS | chr1 | 248,060,682 | 248,061,617 | + |
| 3UTR | chr1 | 248,061,617 | 248,061,620 | + | ||