OR2L5 Olfactory Receptor
| Gene Symbol | OR2L51 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | L |
| Pseudogene | No |
| CORP pseudogene probability score | 0.01 (functional) |
| Aliases | OR1-53, HsOR1.5.23 |
| External Ids | HGNC: 15011 GeneBank: AB065956, AF399485, BK004458, NG_004275 |
| Build #39 labels | OR2L5, OR2L11, OR2L5P |
| Chromosomal location | 1:248,021,948-248,022,883 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2L1P | 90.26% | 308 |
| OR2L2 | 90.06% | 312 |
| OR2L8 | 87.5% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2L3B | 82% | 312 |
| Dog | OR2L5C | 82% | 312 |
| Mouse | Or2l5 | 80% | 312 |
| Rat | Or2l5 | 81% | 307 |
| Rat | Or2l5b | 81% | 307 |
| Cow | OR2L3 | 84% | 312 |
| Orang | OR2L2 | 91% | 312 |
| Orang | OR2L1 | 89% | 312 |
| Horse | OR2L5JP | 85% | 312 |
| Horse | OR2L5D | 85% | 307 |
| Horse | OR2L5E | 82% | 312 |
| Chimp | OR2L5P | 97% | 311 |
Sequence information
| Nucleotide sequence |
ATGGAAAATTACAATCAAACGTCAACTGATTTCATCTTATTGGGGCTGTTCCCACCATCA AAAATTGGCCTTTTCCTCTTCATTCTCTTTGTTCTCATTTTCCTAATGGCTCTAATTGGA AACCTATCCATGATTCTTCTCATCTTCTTGGACACCCATCTCCACACACCCATGTATTTC CTGCTTAGTCAGCTCTCCCTCATTGACCTAAATTACATCTCTACGATTGTTCCTAAGATG GCTTCTGATTTTCTGTATGGAAACAAGTCTATCTCCTTCATTGGGTGTGGGATTCAGAGT TTCTTCTTCATGACTTTTGCAGGTGCAGAAGCGCTGCTCCTGACATCAATGGCCTATGAT CGTTATGTGGCCATTTGCTTTCCTCTCCACTATCCCATCCGTATGAGCAAAAGAATGTAT GTGCTGATGATAACAGGATCTTGGATGATAGGCTCCATCAACTCTTGTGCTCACACAGTA TATGCATTCCGTATCCCATATTGCAAGTCCAGAGCCATCAATCATTTTTTCTGTGATGTT CCAGCTATGTTGACATTAGCCTGTACAGACACCTGGGTCTATGAGTACACAGTGTTTTTG AGCAGCACCATCTTTCTTGTGTTTCCCTTCACTGGCATTGCGTGTTCCTATGGCTGGGTT CTCCTTGCTGTCTACCGCATGCACTCTGCAGAAGGGAGGAAAAAGGCCTATTCGACCTGC AGCACCCACCTCACTGTAGTAACTTTCTACTATGCACCCTTTGCTTATACCTATCTATGT CCAAGATCCCTGCGATCTCTGACAGAGGACAAGGTTCTGGCTGTTTTCTACACCATCCTC ACCCCAATGCTCAACCCCATCATCTACAGCCTGAGAAACAAGGAGGTGATGGGGGCCCTG ACACGAGTGATTCAGAATATCTTCTCGGTGAAAATG |
| Conceptual translation |
MENYNQTSTDFILLGLFPPSKIGLFLFILFVLIFLMALIGNLSMILLIFLDTHLHTPMYF LLSQLSLIDLNYISTIVPKMASDFLYGNKSISFIGCGIQSFFFMTFAGAEALLLTSMAYD RYVAICFPLHYPIRMSKRMYVLMITGSWMIGSINSCAHTVYAFRIPYCKSRAINHFFCDV PAMLTLACTDTWVYEYTVFLSSTIFLVFPFTGIACSYGWVLLAVYRMHSAEGRKKAYSTC STHLTVVTFYYAPFAYTYLCPRSLRSLTEDKVLAVFYTILTPMLNPIIYSLRNKEVMGAL TRVIQNIFSVKM Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 248,186,104 | 248,186,103 | Ins(1) | -/C | rs35816537 (DbSNP) | |
| 1 | 248,185,883 | 248,185,883 | NS | A/G | S/G | rs55982561 (DbSNP) |
| 1 | 248,185,951 | 248,185,951 | SYN | A/G | K/K | rs12753585 (DbSNP) |
| 1 | 248,185,339 | 248,185,339 | SYN | C/T | F/F | rs61748759 (DbSNP) |
| 1 | 248,022,581 | 248,022,581 | NS | G/A | G/S | 1000GP (CEU) |
| 1 | 248,022,698 | 248,022,698 | NS | T/C | Y/H | 1000GP (CHBJPT) |
| 1 | 100 | -100 | SYN | T/C | F/F | 1000GP (YRI, YRI) |
| 1 | 100 | -100 | NS | G/A | R/H | 1000GP (YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
| 1 | 248,145,644 | 248,277,638 | CopyNumber | Variation_48304 (DGV) |
| 1 | 248,179,503 | 248,290,781 | CopyNumber | Variation_74987 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| S152F | R164H | P166S | V198L | G212S | G218D | R226C | Y251H | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | S | R | P | V | G | G | R | Y | 95.31 | 0.019 |
| 2 | S | R | P | V | S | G | R | Y | 1.69 | 0.019 |
| 3 | S | R | P | V | G | G | R | H | 0.92 | 0.005 |
| 4 | S | R | S | V | G | D | R | Y | 0.77 | 0.019 |
| 5 | S | H | P | V | G | G | R | Y | 0.31 | 0.019 |
| 6 | S | R | P | V | G | G | C | Y | 0.31 | 0.019 |
| 7 | S | R | P | V | G | D | R | Y | 0.31 | 0.019 |
| 8 | S | R | P | L | G | G | R | Y | 0.23 | 0.019 |
| 9 | F | R | P | V | G | G | R | Y | 0.08 | 0.019 |
| 10 | S | H | P | V | G | D | R | Y | 0.08 | 0.019 |