OR2T11 Olfactory Receptor
| Gene Symbol | OR2T111 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | T |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR1-65, HsOR1.5.47 |
| External Ids | HGNC: 19574 GeneBank: AB065614, BK004476, NM_001001964 |
| Build #39 labels | OR2T11 |
| Chromosomal location | 1:248,626,181-248,627,128 (-) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs1892443) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2T1 | 66.13% | 310 |
| OR2T2 | 71.01% | 307 |
| OR2T35 | 71.01% | 307 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2T2 | 74% | 311 |
| Mouse | Or2t35 | 70% | 307 |
| Rat | Or2t35 | 72% | 306 |
| Cow | OR2T2 | 73% | 311 |
| Orang | OR2T2P | 69% | 307 |
| Horse | OR2T11E | 89% | 315 |
| Horse | OR2T11DP | 86% | 313 |
| Chimp | OR2T2 | 70% | 307 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC140749 |
| GNF Atlas2 | gnf1h10951_at |
Sequence information
| Nucleotide sequence |
ATGACGAACACATCATCCTCTGACTTCACCCTCCTGGGGCTTCTGGTGAACAGTGAGGCT GCCGGGATTGTATTTACAGTGATCCTTGCTGTTTTCTTGGGGGCCGTGACTGCAAATTTG GTCATGATATTCTTGATTCAGGTGGACTCTCGCCTCCACACCCCCATGTACTTTCTGCTC AGTCAGCTGTCCATCATGGACACCCTTTTCATCTGTACCACTGTCCCAAAACTCCTGGCA GACATGGTTTCTAAAGAGAAGATCATTTCCTTTGTGGCCTGTGGCATCCAGATCTTCCTC TACCTGACCATGATTGGTTCTGAGTTCTTCCTCCTGGGCCTCATGGCCTATGACTGCTAC GTGGCTGTCTGTAACCCTCTGAGATACCCAGTCCTGATGAACCGCAAGAAGTGTCTTTTG CTGGCTGCTGGTGCCTGGTTTGGGGGCTCCCTCGATGGCTTTCTGCTCACTCCCATCACC ATGAATGTCCCTTACTGTGGCTCCCGAAGTATCAACCATTTTTTCTGTGAGATCCCAGCA GTTCTGAAACTGGCCTGTGCAGACACGTCCTTGTATGAAACTCTGATGTACATCTGCTGT GTCCTCATGTTGCTCATCCCCATCTCTATCATCTCCACTTCCTACTCCCTCATCTTGTTA ACCATCCACCGCATGCCCTCTGCTGAAGGTCGCAAAAAGGCCTTCACCACTTGTTCCTCC CACTTGACTGTAGTTAGCATCTTCTATGGGGCTGCCTTCTACACATACGTGCTGCCCCAG TCCTTCCACACCCCCGAGCAGGACAAAGTAGTGTCAGCCTTCTATACCATTGTCACGCCC ATGCTTAATCCTCTCATCTACAGCCTCAGAAACAAGGACGTCATAGGGGCATTTAAAAAG GTATTTGCATGTTGCTCATCTGCTCAGAAAGTAGCAACAAGTGATGCT |
| Conceptual translation |
MTNTSSSDFTLLGLLVNSEAAGIVFTVILAVFLGAVTANLVMIFLIQVDSRLHTPMYFLL SQLSIMDTLFICTTVPKLLADMVSKEKIISFVACGIQIFLYLTMIGSEFFLLGLMAYDCY VAVCNPLRYPVLMNRKKCLLLAAGAWFGGSLDGFLLTPITMNVPYCGSRSINHFFCEIPA VLKLACADTSLYETLMYICCVLMLLIPISIISTSYSLILLTIHRMPSAEGRKKAFTTCSS HLTVVSIFYGAAFYTYVLPQSFHTPEQDKVVSAFYTIVTPMLNPLIYSLRNKDVIGAFKK VFACCSSAQKVATSDA Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 100 | -100 | NS | T/C | Q/R | 1000GP (YRI, YRI) |
| 1 | 248,626,203 | 248,626,203 | NS | T/C | Q/R | 1000GP (CEU, CHBJPT) |
| 1 | 248,626,440 | 248,626,440 | NS | C/A | G/V | 1000GP (CHBJPT) |
| 1 | 248,626,452 | 248,626,452 | NS | G/C | P/R | 1000GP (CEU, CHBJPT) |
| 1 | 248,626,521 | 248,626,521 | NS | A/C | M/R | 1000GP (CEU) |
| 1 | 248,626,774 | 248,626,774 | NS | A/G | C/R | 1000GP (CEU, CHBJPT) |
| 1 | 248,626,866 | 248,626,866 | NS | A/G | I/T | 1000GP (CEU, CHBJPT) |
| 1 | 248,626,898 | 248,626,898 | SYN | T/C | K/K | 1000GP (CEU, CHBJPT) |
| 1 | 248,789,504 | 248,789,504 | NS | C/T | R/Q | rs1892442 (DbSNP) |
| 1 | 248,789,753 | 248,789,753 | NS | C/G | R/P | rs28555577 (DbSNP) |
| 1 | 248,790,075 | 248,790,075 | NS | A/G | C/R | rs1892443 (DbSNP) |
| 1 | 248,790,167 | 248,790,167 | NS | A/G | I/T | rs34397542 (DbSNP) |
| 1 | 248,790,199 | 248,790,199 | SYN | C/T | K/K | rs34674180 (DbSNP) |
| 1 | 248,790,269 | 248,790,269 | NS | G/A | T/I | rs61733992 (DbSNP) |
| 1 | 248,790,425 | 248,790,425 | NS | A/G | M/T | rs41308178 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber, Deletion | 157 (Hasin) | |||
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
| 1 | 248,242,528 | 248,817,382 | CopyNumber | Variation_8935 (DGV) |
| 1 | 248,500,109 | 248,865,374 | CopyNumber | Variation_3340 (DGV) |
| 1 | 248,522,680 | 249,158,239 | CopyNumber | Variation_8355 (DGV) |
| 1 | 248,595,681 | 248,817,382 | CopyNumber | Variation_2359 (DGV) |
| 1 | 248,626,918 | 248,830,541 | Inversion | Variation_37092 (DGV) |
| 1 | 248,644,944 | 248,790,408 | CopyNumber | Variation_0263 (DGV) |
| 1 | 248,687,510 | 248,865,377 | CopyNumber | Variation_0017 (DGV) |
| 1 | 248,701,948 | 248,877,423 | CopyNumber | Variation_2056 (DGV) |
| 1 | 248,703,193 | 248,795,305 | CopyNumber | Variation_75000 (DGV) |
| 1 | 248,727,899 | 248,808,428 | CopyNumber | Variation_38963 (DGV) |
| 1 | 248,727,928 | 248,796,682 | CopyNumber | Variation_6818 (DGV) |
| 1 | 248,729,106 | 248,795,518 | CopyNumber | Variation_66541 (DGV) |
| 1 | 248,732,055 | 248,795,305 | CopyNumber | Variation_74999 (DGV) |
| 1 | 248,738,015 | 248,795,518 | CopyNumber | Variation_66540 (DGV) |
| 1 | 248,738,074 | 248,795,564 | CopyNumber | Variation_31705 (DGV) |
| 1 | 248,749,194 | 248,797,213 | CopyNumber | Variation_38068 (DGV) |
| 1 | 248,749,930 | 248,795,305 | CopyNumber | Variation_74998 (DGV) |
| 1 | 248,751,305 | 248,795,305 | CopyNumber | Variation_84995 (DGV) |
| 1 | 248,784,859 | 248,793,623 | CopyNumber | Variation_1025 (DGV) |
| 1 | 248,787,482 | 248,790,529 | Deletion, CopyNumber | #18 (Waszak) |
| 1 | 248,789,479 | 248,790,429 | CopyNumber | Variation_41248 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| Q309R | T279M | P226R | M203R | C119R | I88T | P55R | T54N | V24A | T2M | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | R | T | P | M | R | I | P | T | V | T | 76.27 | 0.118 |
| 2 | R | T | R | M | R | T | P | T | V | T | 10.14 | 0.118 |
| 3 | Q | T | P | M | C | I | P | T | V | T | 7.14 | 0.703 |
| 4 | R | T | P | M | C | I | P | T | V | T | 4.76 | 0.703 |
| 5 | R | T | P | R | R | I | P | T | V | T | 0.46 | 0.118 |
| 6 | R | T | R | M | R | T | P | N | V | T | 0.23 | 0.118 |
| 7 | R | T | P | M | R | I | P | T | A | T | 0.23 | 0.118 |
| 8 | R | T | P | M | R | T | P | T | V | T | 0.23 | 0.118 |
| 9 | R | T | R | M | R | T | P | T | V | M | 0.08 | 0.118 |
| 10 | R | T | R | M | C | I | P | T | A | T | 0.08 | 0.703 |
| 11 | R | M | P | M | R | I | P | T | V | T | 0.08 | 0.118 |
| 12 | R | T | P | M | R | I | P | T | V | M | 0.08 | 0.118 |
| 13 | R | T | R | M | C | T | P | T | V | T | 0.08 | 0.703 |
| 14 | Q | T | P | M | R | I | P | T | V | T | 0.08 | 0.118 |
| 15 | R | T | P | M | R | I | R | T | V | T | 0.08 | 0.221 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2T11.aApr07-unspliced | main_exon | 3UTR | chr1 | 248,626,178 | 248,626,181 | - |
| CDS | chr1 | 248,626,181 | 248,627,128 | - | ||