OR2T12 Olfactory Receptor
| Gene Symbol | OR2T121 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | T |
| Pseudogene | No |
| CORP pseudogene probability score | 0.12 (functional) |
| Aliases | OR1-57, HsOR1.5.34 |
| External Ids | HGNC: 19592 GeneBank: AB065960, BK004485, NM_001004692 |
| Build #39 labels | OR2T12 |
| Chromosomal location | 1:248,294,619-248,295,578 (-) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2T32P | 96.25% | 320 |
| OR2T33 | 95.31% | 320 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2T22 | 77% | 312 |
| Mouse | Or2t44 | 73% | 316 |
| Rat | Or2t44b | 71% | 314 |
| Cow | OR2T13 | 75% | 312 |
| Orang | OR2T32 | 96% | 320 |
| Orang | OR2T32C | 93% | 320 |
| Horse | OR2T69 | 79% | 314 |
| Chimp | OR2T32 | 97% | 320 |
| Chimp | OR2T32B | 97% | 320 |
Sequence information
| Nucleotide sequence |
ATGGAGATGAGAAATACTACCCCAGATTTTATTCTCCTAGGACTCTTTAACCACACCAGA GCCCACCAAGTCCTCTTCATGATGCTTCTGGCCACCGTTTTGACCTCCCTGTTTAGCAAT GCCCTCATGATTCTCCTGATTCACTGGGACCACCGGCTCCACAGGCCCATGTACTTCCTC CTGAGCCAACTTTCCCTCATGGACATGATGCTGGTTTCCACCACTGTGCCCAAAATGGCG GCTGACTACTTGACCGGAAATAAGGCCATCTCCCGCGCTGGCTGTGGTGTGCAGATCTTC TTCCTCCCCACACTGGGTGGTGGAGAGTGCTTCCTCTTAGCAGCCATGGCCTATGACCGC TATGCGGCTGTCTGCCACCCACTCCGATATCCCACTCTCATGAGCTGGCAGCTGTGCCTG AGGATGACCATGTCGTCCTGGCTCCTGGGTGCAGCTGACGGCCTCCTGCAGGCTGTTGCT ACCCTGAGCTTCCCATATTGCGGTGCACACGAGATCGATCACTTCTTCTGCGAGGCCCCC GTGTTGGTGCGTTTGGCTTGTGCTGACACTTCAGTCTTCGAAAACGCCATGTACATCTGC TGTGTGTTAATGCTCCTGGTCCCCTTTTCCCTCATCCTGTCCTCCTATGGTCTCATCCTC GCTGCTGTTCTGCTCATGCGCTCTACAGAAGCCCGCAAGAAGGCCTTTGCCACCTGCTCT TCACATGTGGCTGTGGTGGGACTCTTTTATGGAGCTGGCATTTTTACCTATATGAGACCC AAATCCCACAGGTCCACTAACCACGATAAGGTTGTGTCAGCCTTCTATACTATGTTCACC CCTTTACTAAATCCCCTCATCTACAGTGTGAGGAACAGTGAGGTCAAGGAAGCCCTGAAA CGGTGGCTGGGGACGTGTGTAAACCTAAAACACCAGCAAAATGAGGCCCACAGGTCAAGA |
| Conceptual translation |
MEMRNTTPDFILLGLFNHTRAHQVLFMMLLATVLTSLFSNALMILLIHWDHRLHRPMYFL LSQLSLMDMMLVSTTVPKMAADYLTGNKAISRAGCGVQIFFLPTLGGGECFLLAAMAYDR YAAVCHPLRYPTLMSWQLCLRMTMSSWLLGAADGLLQAVATLSFPYCGAHEIDHFFCEAP VLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGLILAAVLLMRSTEARKKAFATCS SHVAVVGLFYGAGIFTYMRPKSHRSTNHDKVVSAFYTMFTPLLNPLIYSVRNSEVKEALK RWLGTCVNLKHQQNEAHRSR Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 100 | -100 | NS | T/C | R/G | 1000GP (YRI, YRI) |
| 1 | 100 | -100 | SYN | G/T | T/T | 1000GP (YRI) |
| 1 | 248,295,415 | 248,295,415 | NS | C/G | R/T | 1000GP (CEU) |
| 1 | 248,295,458 | 248,295,458 | NS | C/A | A/S | 1000GP (CEU, CHBJPT) |
| 1 | 248,457,979 | 248,457,979 | NS | A/C | L/R | rs6667171 (DbSNP) |
| 1 | 248,457,993 | 248,457,993 | NS | C/G | K/N | rs11204625 (DbSNP) |
| 1 | 248,458,569 | 248,458,569 | SYN | G/T | T/T | rs35216356 (DbSNP) |
| 1 | 248,458,571 | 248,458,571 | NS | A/T | S/T | rs12137982 (DbSNP) |
| 1 | 248,458,573 | 248,458,573 | NS | A/G | L/P | rs34901845 (DbSNP) |
| 1 | 248,458,575 | 248,458,575 | SYN | C/G | L/L | rs36100041 (DbSNP) |
| 1 | 248,458,676 | 248,458,676 | NS | C/T | V/M | rs6678138 (DbSNP) |
| 1 | 248,458,689 | 248,458,689 | SYN | A/G | L/L | rs6674940 (DbSNP) |
| 1 | 248,458,717 | 248,458,717 | NS | C/G | R/T | rs12745228 (DbSNP) |
| 1 | 248,458,736 | 248,458,736 | NS | A/G | W/R | rs28409263 (DbSNP) |
| 1 | 248,458,760 | 248,458,760 | NS | A/C | S/A | rs12135684 (DbSNP) |
| 1 | 248,458,766 | 248,458,766 | NS | C/T | G/S | rs41310573 (DbSNP) |
| 1 | 248,458,796 | 248,458,796 | NS | C/G | V/L | rs41304145 (DbSNP) |
| 1 | 248,458,876 | 248,458,876 | Del(1) | -/T | rs11339452 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
| 1 | 248,242,528 | 248,817,382 | CopyNumber | Variation_8935 (DGV) |
| 1 | 248,319,780 | 248,490,372 | CopyNumber | Variation_31702 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R301L | K296N | R55T | R55G | W49R | A41S | S39G | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | L | K | T | R | W | A | S | 33.72 | 0.259 |
| 2 | R | K | R | R | W | A | S | 25.04 | 0.259 |
| 3 | L | K | R | R | W | A | S | 16.44 | 0.259 |
| 4 | L | N | T | R | R | S | S | 10.45 | 0.259 |
| 5 | L | N | R | R | R | S | S | 3.07 | 0.259 |
| 6 | L | K | R | G | W | A | S | 2.92 | 0.259 |
| 7 | L | N | R | R | W | A | S | 2.15 | 0.259 |
| 8 | L | K | T | R | W | S | S | 1.54 | 0.259 |
| 9 | L | N | T | R | W | S | S | 1.31 | 0.259 |
| 10 | L | N | T | R | W | A | S | 1.00 | 0.259 |
| 11 | R | K | T | R | W | A | S | 0.46 | 0.259 |
| 12 | R | K | T | R | R | S | S | 0.31 | 0.259 |
| 13 | L | K | R | R | W | S | S | 0.31 | 0.259 |
| 14 | L | K | R | R | W | S | G | 0.23 | 0.259 |
| 15 | R | N | R | R | W | A | S | 0.15 | 0.259 |
| 16 | R | K | R | R | R | S | G | 0.15 | 0.259 |
| 17 | L | N | R | R | W | S | S | 0.15 | 0.259 |
| 18 | R | K | R | R | R | S | S | 0.08 | 0.259 |
| 19 | L | K | R | R | R | A | S | 0.08 | 0.259 |
| 20 | L | K | T | R | R | S | S | 0.08 | 0.259 |
| 21 | R | K | R | R | R | A | S | 0.08 | 0.259 |
| 22 | R | N | T | R | W | A | S | 0.08 | 0.259 |
| 23 | R | K | R | G | W | A | S | 0.08 | 0.259 |
| 24 | L | K | R | R | R | S | S | 0.08 | 0.259 |
| 25 | L | K | R | R | R | S | G | 0.08 | 0.259 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2T12.aApr07-unspliced | main_exon | 3UTR | chr1 | 248,294,616 | 248,294,619 | - |
| CDS | chr1 | 248,294,619 | 248,295,578 | - | ||