OR2T6 Olfactory Receptor
| Gene Symbol | OR2T61 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | T |
| Pseudogene | No |
| CORP pseudogene probability score | 0.06 (functional) |
| Aliases | HsOR1.5.38 |
| External Ids | HGNC: 15018 GeneBank: AF399481, NM_001005471 |
| Build #39 labels | OR2T6P, OR2T9 |
| Chromosomal location | 1:248,387,609-248,388,532 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2T1 | 72.79% | 305 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2T1 | 73% | 305 |
| Mouse | Or2t6 | 82% | 305 |
| Rat | Or2t6 | 81% | 305 |
| Cow | OR2T1 | 73% | 305 |
| Orang | OR2T27 | 65% | 308 |
| Horse | OR2T6B | 84% | 307 |
| Horse | OR2T6C | 82% | 307 |
| Horse | OR2T6D | 84% | 271 |
| Chimp | OR2T1 | 73% | 305 |
Expression evidences
| Source | Accession |
|---|---|
| GNF Atlas2 | gnf1h10656_at |
Sequence information
| Nucleotide sequence |
ATGAATGAAAACAATGAAACCTTGACCAGAGGCTTTACCCTCATGGGGCTCTTCACTCAC AATAAATGCTCAGGATTCTTTTTCGGTGTCATTTGTGCCGTCTTCTTCATGGCCATGATA GCTAATGGGGTCATGATCTTCCTGATTAACATAGACCCTCATCTCCACACCCCCATGTAC TTCCTCCTCAGCCACCTCTCCGTCATTGACACATTATACATCTCCACCATTGTGCCCAAG ATGCTGGTAGATTATCTCATGGGCGAGGGGACCATCTCTTTCATCGCCTGCACTGCTCAG TGCTTTCTCTACATGGGCTTTATGGGGGCTGAATTCTTCCTGCTGGGGCTCATGGCCTAT GACCGCTACGTGGCCATCTGCAACCCACTGCGCTATCCTGTCCTCATCAGCTGGCGGGTC TGCTGGATGATCCTGGCCAGCTCTTGGTTCGGTGGGGCTTTGGACAGTTTTCTCCTCACC CCCATTACCATGAGTCTCCCGTTCTGTGCCTCTCACCAAATCAATCACTTTTTCTGTGAG GCACCCACCATGCTGAGGCTGGCCTGTGGGGACAAAACCACCTATGAAACAGTGATGTAT GTGTGCTGCGTTGCAATGCTGCTGATCCCCTTCTCGGTGGTGACTGCATCCTACACCAGG ATTCTCATCACAGTGCATCAGATGACATCGGCTGAAGGGAGGAAGAAGGCCTTTGCCACC TGCTCTTCACACATGATGGTGGTGACATTGTTCTATGGGGCTGCCTTGTATACGTATACG CTTCCCCAATCTTACCACACCCCAATCAAAGATAAGGTCTTCTCTGCCTTTTATACCATC CTCACACCCTTATTAAACCCTCTCATCTACAGTCTGAGGAACAGGGATGTGATGGGTGCC TTGAAGAGAGTTGTGGCAAGATGT |
| Conceptual translation |
MNENNETLTRGFTLMGLFTHNKCSGFFFGVICAVFFMAMIANGVMIFLINIDPHLHTPMY FLLSHLSVIDTLYISTIVPKMLVDYLMGEGTISFIACTAQCFLYMGFMGAEFFLLGLMAY DRYVAICNPLRYPVLISWRVCWMILASSWFGGALDSFLLTPITMSLPFCASHQINHFFCE APTMLRLACGDKTTYETVMYVCCVAMLLIPFSVVTASYTRILITVHQMTSAEGRKKAFAT CSSHMMVVTLFYGAALYTYTLPQSYHTPIKDKVFSAFYTILTPLLNPLIYSLRNRDVMGA LKRVVARC Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 248,551,466 | 248,551,465 | Ins(1) | -/G | rs34365091 (DbSNP) | |
| 1 | 248,551,079 | 248,551,079 | NS | A/C | N/T | rs6693032 (DbSNP) |
| 1 | 248,550,916 | 248,550,916 | NS | A/G | K/E | rs60632569 (DbSNP) |
| 1 | 248,550,970 | 248,550,970 | NS | A/G | N/D | rs7417616 (DbSNP) |
| 1 | 248,551,204 | 248,551,204 | NS | A/G | T/A | rs6683656 (DbSNP) |
| 1 | 248,551,174 | 248,551,174 | NS | A/G | K/E | rs61736246 (DbSNP) |
| 1 | 248,551,009 | 248,551,009 | NS | A/G | I/V | rs41308164 (DbSNP) |
| 1 | 248,551,727 | 248,551,727 | NS | A/T | D/V | rs56967655 (DbSNP) |
| 1 | 248,551,484 | 248,551,484 | NS | C/A | T/K | rs4454573 (DbSNP) |
| 1 | 248,551,385 | 248,551,385 | NS | C/T | P/L | rs6701129 (DbSNP) |
| 1 | 248,551,598 | 248,551,598 | NS | C/T | S/L | rs61736247 (DbSNP) |
| 1 | 248,551,636 | 248,551,636 | NS | G/T | A/S | rs954475 (DbSNP) |
| 1 | 248,550,976 | 248,550,976 | NS | G/T | G/C | rs6587467 (DbSNP) |
| 1 | 248,551,319 | 248,551,319 | NS | T/G | I/S | rs2226010 (DbSNP) |
| 1 | 248,550,942 | 248,550,942 | SYN | A/C | G/G | rs60321142 (DbSNP) |
| 1 | 248,551,146 | 248,551,146 | SYN | C/G | P/P | rs72766981 (DbSNP) |
| 1 | 248,551,560 | 248,551,560 | SYN | C/T | S/S | rs954474 (DbSNP) |
| 1 | 248,551,164 | 248,551,164 | SYN | C/T | Y/Y | rs61736242 (DbSNP) |
| 1 | 248,551,203 | 248,551,203 | SYN | C/T | T/T | rs6700947 (DbSNP) |
| 1 | 248,550,993 | 248,550,993 | SYN | C/T | F/F | rs61736237 (DbSNP) |
| 1 | 248,551,194 | 248,551,194 | SYN | C/T | I/I | rs6693133 (DbSNP) |
| 1 | 248,551,128 | 248,551,128 | SYN | C/T | Y/Y | rs61736241 (DbSNP) |
| 1 | 248,388,335 | 248,388,335 | NS | T/G | S/A | 1000GP (CEU, CHBJPT) |
| 1 | 248,387,669 | 248,387,669 | NS | A/G | N/D | 1000GP (CEU, CHBJPT) |
| 1 | 248,387,675 | 248,387,675 | NS | T/G | C/G | 1000GP (CEU, CHBJPT) |
| 1 | 248,388,259 | 248,388,259 | SYN | C/T | S/S | 1000GP (CEU, CHBJPT) |
| 1 | 248,387,902 | 248,387,902 | SYN | T/C | T/T | 1000GP (CEU, CHBJPT) |
| 1 | 248,388,181 | 248,388,181 | NS | C/A | D/E | 1000GP (CHBJPT) |
| 1 | 100 | -100 | NS | G/A | E/K | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 1 | 100 | -100 | SYN | C/A | G/G | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 248,500,109 | 248,865,374 | CopyNumber | Variation_3340 (DGV) |
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
| 1 | 248,522,680 | 249,158,239 | CopyNumber | Variation_8355 (DGV) |
| 1 | 248,242,528 | 248,817,382 | CopyNumber | Variation_8935 (DGV) |
| 1 | 248,550,810 | 248,553,833 | CopyNumber | #32 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| E3K | V34I | T57N | E89K | I92F | A96T | A99T | R139W | A146V | L159P | S230L | S243A | T258M | V273D | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | E | V | T | E | I | A | A | R | A | L | S | S | T | V | 63.13 | 0.158 |
| 2 | E | V | T | E | I | A | A | R | A | L | S | A | T | V | 29.03 | 0.158 |
| 3 | E | V | N | E | I | A | T | R | A | P | S | A | T | V | 3.15 | 0.158 |
| 4 | K | V | T | K | I | A | A | R | A | L | S | S | T | D | 1.08 | 0.158 |
| 5 | E | V | N | E | I | A | A | R | A | P | S | A | T | V | 0.84 | 0.158 |
| 6 | E | I | T | E | I | A | A | R | A | L | S | S | T | V | 0.54 | 0.158 |
| 7 | E | V | T | E | I | T | A | R | A | L | S | S | T | V | 0.46 | 0.158 |
| 8 | E | V | T | E | I | A | A | W | A | L | S | S | T | V | 0.38 | 0.158 |
| 9 | E | V | T | E | I | A | A | R | A | P | S | A | T | V | 0.31 | 0.158 |
| 10 | E | V | T | E | I | A | A | R | V | L | S | A | T | V | 0.23 | 0.158 |
| 11 | E | V | T | E | F | A | A | R | A | L | S | S | T | V | 0.15 | 0.238 |
| 12 | K | V | T | K | I | A | A | R | A | L | S | S | T | V | 0.15 | 0.158 |
| 13 | E | V | N | E | I | A | A | R | A | L | S | S | T | V | 0.15 | 0.158 |
| 14 | E | V | T | E | I | A | A | R | A | L | L | S | T | V | 0.15 | 0.158 |
| 15 | E | V | T | E | F | A | A | R | A | P | S | A | T | V | 0.08 | 0.238 |
| 16 | E | V | T | E | I | T | A | R | A | L | S | A | T | V | 0.08 | 0.158 |
| 17 | E | V | T | E | I | A | A | R | A | L | S | S | M | V | 0.08 | 0.158 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2T6.aApr07-unspliced | main_exon | CDS | chr1 | 248,387,609 | 248,388,532 | + |
| 3UTR | chr1 | 248,388,532 | 248,388,535 | + | ||