OR2V2 Olfactory Receptor
| Gene Symbol | OR2V21 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | V |
| Pseudogene | No |
| CORP pseudogene probability score | 0.03 (functional) |
| Aliases | OR5-3, HsOR5.4.4, ORL3204 |
| External Ids | HGNC: 15341 GeneBank: AB065675, AF399614, BK004246, NM_206880 ORDB: ORL3204 |
| Build #39 labels | OR2V3, OR2V2 |
| Chromosomal location | 5:181,154,943-181,155,887 (+) |
| Cluster | 5@181a |
| Synteny | CLIC#11 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2V1 | 87.3% | 315 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2V1 | 84% | 315 |
| Mouse | Or2v1 | 83% | 315 |
| Mouse | Or2v2 | 83% | 314 |
| Rat | Or2v2b | 85% | 315 |
| Rat | Or2v2 | 85% | 312 |
| Rat | Or2v2c | 84% | 315 |
| Rat | Or2v1 | 82% | 315 |
| Cow | OR2V2D | 85% | 314 |
| Orang | OR2V1 | 88% | 315 |
| Orang | OR2V1BP | 87% | 315 |
| Orang | OR2V1CP | 87% | 245 |
| Horse | OR2V1 | 79% | 314 |
| Chimp | OR2V1 | 88% | 315 |
Sequence information
| Nucleotide sequence |
ATGGAGACGTGGGTGAACCAGTCCTACACAGATGGCTTCTTCCTCTTAGGCATCTTCTCC CACAGTACTGCTGACCTTGTCCTCTTCTCCGTGGTTATGGCGGTCTTCACAGTGGCCCTC TGTGGGAATGTCCTCCTCATCTTCCTCATCTACATGGACCCTCACCTTCACACCCCCATG TACTTCTTCCTCAGCCAGCTCTCCCTCATGGACCTCATGTTGGTCTGTACCAATGTGCCA AAGATGGCAGCCAACTTCCTGTCTGGCAGGAAGTCCATCTCCTTTGTGGGCTGTGGCATA CAAATTGGCCTCTTTGTCTGTCTTGTGGGATCTGAGGGGCTCTTGCTGGGACTCATGGCT TATGACCGCTATGTGGCCATTAGCCACCCACTTCACTATCCCATCCTCATGAATCAGAGG GTCTGTCTCCAGATTACTGGGAGCTCCTGGGCCTTTGGGATAATCGATGGCTTGATCCAG ATGGTGGTAGTAATGAATTTCCCCTACTGTGGCTTGAGGAAGGTGAACCATTTCTTCTGT GAGATGCTATCCTTGTTGAAGCTGGCCTGTGTAGACACATCCCTGTTTGAGAAGGTGATA TTTGCTTGCTGTGTCTTCATGCTTCTCTTCCCATTCTCCATCATCGTGGCCTCCTATGCT CACATTCTAGGGACTGTGCTGCAAATGCACTCTGCTCAGGCCTGGAAAAAGGCCCTGGCC ACCTGCTCCTCCCACCTGACAGCTGTCACCCTCTTCTATGGGGCAGCCATGTTCATCTAC CTGAGGCCTAGGCACTACCGGGCCCCCAGCCATGACAAGGTGGCCTCTATCTTCTACACG GTCCTTACTCCCATGCTCAACCCCCTCATTTACAGCTTGAGGAACAGGGAGGTGATGGGG GCACTGAGGAAGGGGCTGGACCGCTGCAGGATCGGCAGCCAGCAC |
| Conceptual translation |
METWVNQSYTDGFFLLGIFSHSTADLVLFSVVMAVFTVALCGNVLLIFLIYMDPHLHTPM YFFLSQLSLMDLMLVCTNVPKMAANFLSGRKSISFVGCGIQIGLFVCLVGSEGLLLGLMA YDRYVAISHPLHYPILMNQRVCLQITGSSWAFGIIDGLIQMVVVMNFPYCGLRKVNHFFC EMLSLLKLACVDTSLFEKVIFACCVFMLLFPFSIIVASYAHILGTVLQMHSAQAWKKALA TCSSHLTAVTLFYGAAMFIYLRPRHYRAPSHDKVASIFYTVLTPMLNPLIYSLRNREVMG ALRKGLDRCRIGSQH Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 5 | 180,582,321 | 180,582,321 | NS | A/G | I/V | rs57951228 (DbSNP) |
| 5 | 180,582,043 | 180,582,043 | NS | C/T | A/V | rs17617270 (DbSNP) |
| 5 | 180,582,604 | 180,582,604 | NS | G/A | R/H | rs2546423 (DbSNP) |
| 5 | 180,582,314 | 180,582,314 | SYN | C/T | Y/Y | rs12108779 (DbSNP) |
| 5 | 181,155,604 | 181,155,604 | NS | A/G | H/R | 1000GP (CEU, CHBJPT) |
| 5 | 181,155,043 | 181,155,043 | NS | C/T | A/V | 1000GP (CEU) |
| 5 | 100 | -100 | SYN | C/T | V/V | 1000GP (YRI, YRI) |
| 5 | 100 | -100 | NS | A/G | I/V | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 5 | 180,433,880 | 180,614,665 | CopyNumber | Variation_29766 (DGV) |
| 5 | 180,553,399 | 180,587,578 | CopyNumber | Variation_36381 (DGV) |
| 5 | 180,433,880 | 180,633,854 | CopyNumber | Variation_53320 (DGV) |
| 5 | 180,545,057 | 180,598,061 | Inversion | Variation_59820 (DGV) |
| 5 | 180,532,601 | 180,598,197 | Inversion | Variation_103362 (DGV) |
| 5 | 180,581,843 | 180,584,887 | CopyNumber | #110 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L64F | I127V | L209P | H221R | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | L | I | L | R | 61.14 | 0.087 |
| 2 | L | I | L | H | 37.63 | 0.087 |
| 3 | L | V | L | R | 0.61 | 0.087 |
| 4 | F | I | L | R | 0.38 | 0.044 |
| 5 | L | I | P | R | 0.23 | 0.087 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2V2.aApr07-unspliced | main_exon | CDS | chr5 | 181,154,943 | 181,155,887 | + |
| 3UTR | chr5 | 181,155,887 | 181,155,890 | + | ||