OR2W3 Olfactory Receptor
| Gene Symbol | OR2W31 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | W |
| Pseudogene | No |
| CORP pseudogene probability score | 0.54 (pseudogene) |
| Aliases | OR1-49, HsOR1.5.15 |
| External Ids | HGNC: 15021 GeneBank: AB065949, AF399491, BK004456, HSM805734, NM_001001957 |
| Build #39 labels | OR2W8P, OR2W3P |
| Chromosomal location | 1:247,895,587-247,896,528 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2W2P | 67.55% | 302 |
| OR2W6P | 66.56% | 305 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2W4 | 66% | 310 |
| Mouse | Or2w3c | 85% | 313 |
| Mouse | Or2w3 | 85% | 313 |
| Mouse | Or2w3b | 83% | 313 |
| Rat | Or2w2 | 73% | 304 |
| Cow | OR2W3D | 84% | 314 |
| Orang | OR2W2 | 70% | 310 |
| Horse | OR2W3FP | 79% | 312 |
| Chimp | OR2W3DP | 97% | 221 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | N75737 |
| mRNA | EU831842 |
| GNF Atlas2 | gnf1h02157_at |
Sequence information
| Nucleotide sequence |
ATGGATGGAACCAATGGCAGCACCCAAACCCATTTCATCCTACTGGGATTCTCTGACCGA CCCCATCTGGAGAGGATCCTCTTTGTGGTCATCCTGATCGCGTACCTCCTGACCCTCGTA GGCAACACCACCATCATCCTGGTGTCCCGGCTGGACCCCCACCTCCACACCCCCATGTAC TTCTTCCTCGCCCACCTTTCCTTCCTGGACCTCAGTTTCACCACCAGCTCCATCCCCCAG CTGCTCTACAACCTTAATGGATGTGACAAGACCATCAGCTACATGGGCTGTGCCATCCAG CTCTTCCTGTTCCTGGGTCTGGGTGGTGTGGAGTGCCTGCTTCTGGCTGTCATGGCCTAT GACCGGTGTGTGGCTATCTGCAAGCCCCTGCACTACATGGTGATCATGAACCCCAGGCTC TGCCGGGGCTTGGTGTCAGTGACCTGGGGCTGTGGGGTGGCCAACTCCTTGGCCATGTCT CCTGTGACCCTGCGCTTACCCCGCTGTGGGCACCACGAGGTGGACCACTTCCTGCGTGAG ATGCCCGCCCTGATCCGGATGGCCTGCGTCAGCACTGTGGCCATCGAAGGCACCGTCTTT GTCCTGGCGGTGGGTGTTGTGCTGTCCCCCTTGGTGTTTATCCTGCTCTCTTACAGCTAC ATTGTGAGGGCTGTGTTACAAATTCGGTCAGCATCAGGAAGGCAGAAGGCCTTCGGCACC TGCGGCTCCCATCTCACTGTGGTCTCCCTTTTCTATGGAAACATCATCTACATGTACATG CAGCCAGGAGCCAGTTCTTCCCAGGACCAGGGCATGTTCCTCATGCTCTTCTACAACATT GTCACCCCCCTCCTCAATCCTCTCATCTACACCCTCAGAAACAGAGAGGTGAAGGGGGCA CTGGGAAGGTTGCTTCTGGGGAAGAGAGAGCTAGGAAAGGAG |
| Conceptual translation |
MDGTNGSTQTHFILLGFSDRPHLERILFVVILIAYLLTLVGNTTIILVSRLDPHLHTPMY FFLAHLSFLDLSFTTSSIPQLLYNLNGCDKTISYMGCAIQLFLFLGLGGVECLLLAVMAY DRCVAICKPLHYMVIMNPRLCRGLVSVTWGCGVANSLAMSPVTLRLPRCGHHEVDHFLRE MPALIRMACVSTVAIEGTVFVLAVGVVLSPLVFILLSYSYIVRAVLQIRSASGRQKAFGT CGSHLTVVSLFYGNIIYMYMQPGASSSQDQGMFLMLFYNIVTPLLNPLIYTLRNREVKGA LGRLLLGKRELGKE Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 248,059,147 | 248,059,146 | Ins(1) | -/G | rs34301279 (DbSNP) | |
| 1 | 248,059,476 | 248,059,476 | NS | A/C | E/D | rs12139390 (DbSNP) |
| 1 | 248,059,151 | 248,059,151 | NS | A/G | Y/C | rs61748699 (DbSNP) |
| 1 | 248,059,078 | 248,059,078 | NS | A/G | T/A | rs61752499 (DbSNP) |
| 1 | 248,059,483 | 248,059,483 | NS | A/G | I/V | rs61756679 (DbSNP) |
| 1 | 248,059,456 | 248,059,456 | NS | A/G | I/V | rs12135078 (DbSNP) |
| 1 | 248,059,703 | 248,059,703 | NS | A/T | K/M | rs11204545 (DbSNP) |
| 1 | 248,059,394 | 248,059,394 | NS | C/G | S/C | rs12083024 (DbSNP) |
| 1 | 248,059,712 | 248,059,712 | NS | C/T | T/M | rs11204546 (DbSNP) |
| 1 | 248,059,150 | 248,059,150 | NS | C/T | R/C | rs61748698 (DbSNP) |
| 1 | 248,059,423 | 248,059,423 | NS | C/T | R/C | rs10888267 (DbSNP) |
| 1 | 248,059,252 | 248,059,252 | NS | C/T | R/W | rs61750779 (DbSNP) |
| 1 | 248,059,602 | 248,059,602 | SYN | C/T | F/F | rs61748719 (DbSNP) |
| 1 | 247,896,121 | 247,896,121 | NS | C/T | R/C | 1000GP (CEU, CHBJPT) |
| 1 | 247,896,174 | 247,896,174 | NS | A/C | E/D | 1000GP (CEU, CHBJPT) |
| 1 | 247,896,154 | 247,896,154 | NS | G/A | V/I | 1000GP (CEU, CHBJPT) |
| 1 | 247,896,401 | 247,896,401 | NS | T/A | M/K | 1000GP (CEU, CHBJPT) |
| 1 | 247,896,410 | 247,896,410 | NS | T/C | M/T | 1000GP (CEU, CHBJPT) |
| 1 | 247,895,625 | 247,895,625 | SYN | C/T | I/I | 1000GP (CHBJPT) |
| 1 | 247,895,950 | 247,895,950 | NS | C/T | R/W | 1000GP (CHBJPT) |
| 1 | 247,896,502 | 247,896,502 | SYN | C/T | L/L | 1000GP (CHBJPT) |
| 1 | 100 | -100 | NS | G/A | A/T | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 1 | 100 | -100 | SYN | C/T | F/F | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
| CopyNumber | 1 (Hasin) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| A64T | C88R | C88Y | R122W | C169S | R179C | V190I | E196D | V199I | M272K | M275T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | A | C | C | R | C | C | I | D | V | K | T | 35.10 | 0.359 |
| 2 | A | C | C | R | C | R | V | E | V | M | M | 26.65 | 0.703 |
| 3 | A | C | C | R | C | R | V | D | V | M | M | 12.60 | 0.703 |
| 4 | A | C | C | W | C | R | V | E | V | M | M | 6.76 | 0.977 |
| 5 | A | C | C | R | C | R | V | D | V | K | T | 4.53 | 0.703 |
| 6 | A | C | C | R | C | R | I | D | V | K | T | 2.30 | 0.703 |
| 7 | A | C | C | R | C | R | V | E | V | K | T | 2.00 | 0.703 |
| 8 | A | C | C | R | S | C | V | E | V | K | T | 1.77 | 0.359 |
| 9 | A | C | C | R | C | C | V | E | V | K | T | 1.54 | 0.359 |
| 10 | A | C | C | R | C | C | I | D | V | M | M | 1.08 | 0.359 |
| 11 | A | C | C | R | C | C | V | D | V | K | T | 1.00 | 0.359 |
| 12 | A | R | Y | W | C | R | V | E | V | M | M | 0.69 | 0.977 |
| 13 | T | C | Y | R | C | R | V | E | V | M | M | 0.46 | 0.703 |
| 14 | A | C | C | W | C | C | V | E | V | K | T | 0.38 | 0.909 |
| 15 | A | C | C | R | C | R | I | D | V | M | M | 0.31 | 0.703 |
| 16 | A | C | C | R | C | R | V | E | I | M | M | 0.31 | 0.703 |
| 17 | A | C | Y | W | C | R | V | E | V | M | M | 0.31 | 0.977 |
| 18 | A | C | C | W | C | C | I | E | V | K | T | 0.23 | 0.909 |
| 19 | A | C | C | R | C | C | V | D | V | M | M | 0.15 | 0.359 |
| 20 | A | C | C | W | C | C | I | D | V | K | T | 0.15 | 0.909 |
| 21 | A | C | C | W | C | R | V | E | I | M | M | 0.15 | 0.977 |
| 22 | A | C | C | W | C | R | V | D | V | M | M | 0.15 | 0.977 |
| 23 | A | R | Y | W | C | R | V | E | V | K | T | 0.15 | 0.977 |
| 24 | A | C | C | W | C | R | V | E | V | K | T | 0.15 | 0.977 |
| 25 | A | C | C | W | C | R | V | D | V | K | T | 0.15 | 0.977 |
| 26 | A | R | Y | R | C | R | V | D | V | M | M | 0.15 | 0.703 |
| 27 | A | C | C | R | C | R | V | D | V | M | T | 0.08 | 0.703 |
| 28 | A | R | Y | R | C | C | I | E | V | K | T | 0.08 | 0.359 |
| 29 | A | C | Y | R | C | C | V | E | V | K | T | 0.08 | 0.359 |
| 30 | A | R | Y | R | C | R | V | D | V | K | T | 0.08 | 0.703 |
| 31 | A | R | Y | R | C | C | I | D | V | K | T | 0.08 | 0.359 |
| 32 | A | C | Y | R | C | R | V | E | V | K | T | 0.08 | 0.703 |
| 33 | T | C | C | R | C | R | V | D | V | M | M | 0.08 | 0.703 |
| 34 | A | C | C | R | C | R | V | E | V | M | T | 0.08 | 0.703 |
| 35 | A | C | C | W | C | C | I | E | V | M | M | 0.08 | 0.909 |
| 36 | A | C | C | R | C | C | I | E | V | K | T | 0.08 | 0.359 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| TRIM58andOR2W3.bApr07 | exon_5UTR | chr1 | 247,867,975 | 247,868,063 | + | |
| exon_5UTR | chr1 | 247,875,900 | 247,876,037 | + | ||
| main_exon | 5UTR | chr1 | 247,895,557 | 247,895,587 | + | |
| CDS | chr1 | 247,895,587 | 247,896,528 | + | ||
| 3UTR | chr1 | 247,896,528 | 247,897,408 | + | ||