OR2Z1 Olfactory Receptor
| Gene Symbol | OR2Z11 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | Z |
| Pseudogene | No |
| CORP pseudogene probability score | 0.8 (pseudogene) |
| Aliases | OR19-4, HsOR19.2.1, ORL3763, ORL3764 |
| External Ids | HGNC: 15391 GeneBank: AB065930, AF399619, BK004262, NM_001004699 ORDB: ORL3763, ORL3764 |
| Build #39 labels | OR2Z1 |
| Chromosomal location | 19:8,731,029-8,731,970 (+) |
| Cluster | 19@9a |
| Synteny | CLIC#41 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2T32P | 54% | 300 |
| OR2T35 | 53.29% | 304 |
| OR2T8 | 53.47% | 303 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2Z3 | 74% | 269 |
| Mouse | Or2z8 | 75% | 311 |
| Rat | Or2z10-ps | 71% | 283 |
| Cow | OR2Z11 | 78% | 309 |
| Orang | OR2T27 | 54% | 308 |
| Horse | OR2Z1B | 86% | 311 |
| Chimp | OR2T27 | 53% | 308 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC151149 |
| GNF Atlas2 | gnf1h10963_at |
Sequence information
| Nucleotide sequence |
ATGGGGGATGTGAATCAGTCGGTGGCCTCAGACTTCATTCTGGTGGGCCTCTTCAGTCAC TCAGGATCACGCCAGCTCCTCTTCTCCCTGGTGGCTGTCATGTTTGTCATAGGCCTTCTG GGCAACACCGTTCTTCTCTTCTTGATCCGTGTGGACTCCCGGCTCCATACACCCATGTAC TTCCTGCTCAGCCAGCTCTCCCTGTTTGACATTGGCTGTCCCATGGTCACCATCCCCAAG ATGGCATCAGACTTTCTGCGGGGAGAAGGTGCCACCTCCTATGGAGGTGGTGCAGCTCAA ATATTCTTCCTCACACTGATGGGTGTGGCTGAGGGCGTCCTGTTGGTCCTCATGTCTTAT GACCGTTATGTTGCTGTGTGCCAGCCCCTGCAGTATCCTGTACTTATGAGACGCCAGGTA TGTCTGCTGATGATGGGCTCCTCCTGGGTGGTAGGTGTGCTCAACGCCTCCATCCAGACC TCCATCACCCTGCATTTTCCCTACTGTGCCTCCCGTATTGTGGATCACTTCTTCTGTGAG GTGCCAGCCCTACTGAAGCTCTCCTGTGCAGATACCTGTGCCTACGAGATGGCGCTGTCC ACCTCAGGGGTGCTGATCCTAATGCTCCCTCTTTCCCTCATCGCCACCTCCTACGGCCAC GTGTTGCAGGCTGTTCTAAGCATGCGCTCAGAGGAGGCCAGACACAAGGCTGTCACCACC TGCTCCTCGCACATCACGGTAGTGGGGCTCTTTTATGGTGCCGCCGTGTTCATGTACATG GTGCCTTGCGCCTACCACAGTCCACAGCAGGATAACGTGGTTTCCCTCTTCTATAGCCTT GTCACCCCTACACTCAACCCCCTTATCTACAGTCTGAGGAATCCGGAGGTGTGGATGGCT TTGGTCAAAGTGCTTAGCAGAGCTGGACTCAGGCAAATGTGC |
| Conceptual translation |
MGDVNQSVASDFILVGLFSHSGSRQLLFSLVAVMFVIGLLGNTVLLFLIRVDSRLHTPMY FLLSQLSLFDIGCPMVTIPKMASDFLRGEGATSYGGGAAQIFFLTLMGVAEGVLLVLMSY DRYVAVCQPLQYPVLMRRQVCLLMMGSSWVVGVLNASIQTSITLHFPYCASRIVDHFFCE VPALLKLSCADTCAYEMALSTSGVLILMLPLSLIATSYGHVLQAVLSMRSEEARHKAVTT CSSHITVVGLFYGAAVFMYMVPCAYHSPQQDNVVSLFYSLVTPTLNPLIYSLRNPEVWMA LVKVLSRAGLRQMC Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 19 | 100 | -100 | NS | G/A | R/H | 1000GP (YRI) |
| 19 | 100 | -100 | SYN | T/C | H/H | 1000GP (YRI, YRI, YRI) |
| 19 | 8,731,196 | 8,731,196 | SYN | T/C | H/H | 1000GP (CEU, CHBJPT) |
| 19 | 8,841,461 | 8,841,461 | NS | A/G | H/R | rs61746162 (DbSNP) |
| 19 | 8,841,558 | 8,841,558 | SYN | T/C | H/H | rs28324 (DbSNP) |
| 19 | 8,841,793 | 8,841,793 | NS | C/T | L/F | rs61746164 (DbSNP) |
| 19 | 8,841,802 | 8,841,802 | NS | C/T | R/C | rs58741481 (DbSNP) |
| 19 | 8,841,807 | 8,841,807 | SYN | A/G | Q/Q | rs1078042 (DbSNP) |
| 19 | 8,841,810 | 8,841,810 | SYN | A/G | V/V | rs59262334 (DbSNP) |
| 19 | 8,841,891 | 8,841,891 | SYN | A/C | P/P | rs11881829 (DbSNP) |
| 19 | 8,841,963 | 8,841,963 | SYN | T/C | D/D | rs890848 (DbSNP) |
| 19 | 8,842,138 | 8,842,138 | NS | A/C | I/L | rs73489595 (DbSNP) |
| 19 | 8,842,168 | 8,842,168 | NS | A/C | M/L | rs61746161 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 237 (Hasin) | |||
| 19 | 8,804,784 | 8,875,725 | CopyNumber | Variation_5079 (DGV) |
| 19 | 8,820,095 | 8,853,315 | CopyNumber | Variation_0808 (DGV), Variation_2239 (DGV), Variation_5080 (DGV) |
| 19 | 8,830,080 | 8,881,965 | CopyNumber | Variation_35691 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R24H | L135F | % Freq | CORP | |
|---|---|---|---|---|
| 1 | R | L | 97.05 | 0.966 |
| 2 | H | L | 1.75 | 0.966 |
| 3 | R | F | 1.20 | 0.966 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2Z1.aApr07-unspliced | main_exon | CDS | chr19 | 8,731,029 | 8,731,970 | + |
| 3UTR | chr19 | 8,731,970 | 8,731,973 | + | ||