OR3A4 Olfactory Receptor
| Gene Symbol | OR3A4 (View this gene in GeneCards) |
| Family | 3 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 1 (pseudogene) |
| Aliases | OR17-16, OR17-24, OR17-13, OR17-25, HsOR17.1.12, ORL69 |
| External Ids | GeneBank: AF087920, AF087921, AF399621, BK004695, BK004725, HSU04680, NM_001005334 ORDB: ORL69 |
| Build #39 labels | OR3A4 |
| Chromosomal location | 17:3,310,311-3,311,354 (+) |
| Cluster | 17@3b |
| Synteny | CLIC#39 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR3A3 | 72.01% | 293 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR3A10 | 71% | 300 |
| Mouse | Or3a10 | 72% | 293 |
| Rat | Or3a4 | 84% | 293 |
| Cow | OR3A10 | 73% | 293 |
| Orang | OR3A4P | 94% | 293 |
| Horse | OR3A16 | 73% | 293 |
| Chimp | OR3A4P | 95% | 293 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136875 |
Sequence information
| Nucleotide sequence |
ATGGATCTGGGGAACTCAGGGAATGATTCAGTTGTGACCAAGTTTGTCCTGCTGGGCCTC ACAGAGACTGCAGCTCTACAGCCCATCCTCTTTGTCATCTTCCTTCTTGCTTACGTCACT ACCATTGGAGGCACCCTCAGCATCCTGGCGGCCATCCTTATGGAAACCAAACTCCACAGC CCCATGTACTTCTTCCTGGGGAACTTGTCCCTGCCAGATGTGGGGTGTGTCAGTGTCACT GTCCCTGCCATGCTGAGCCATTTCATATCCAACGACAGAAGCATTCCCTATAAGGCCTGC CTCTCCGAGCTCTTCTTCTTCCACCTCCTGGCTGGGGCAGACTGCTTCTTGCTGACCATC ATGGCCTATGACCGCTATCTGGCCATCTGCCAGTCCCTCACCTACAGCAGCCGCATGAGC TGGGGAATCCAGCAAGCCCTGGTGGGCATGTCATGTGTCTTTTCCTTCACCAATGCACTG ACCCAAACTGTTGCCCTGTCTCCTCTTAACTTCTGTGGCCCCAATGTGATCAATCACTTC TACTGTGACCTCCCACAGCCCTTCCAGCTCTCCTGCTCCAGTGTTCATCTCAATGGGCAG TTGCTGTTTGTAGCAGCAGCTTTCATGGGTGTGGCCCCCTTGGTCCTCATCACTGTGTCC TATGCCCATGTGGCAGCTGCAGTCCTGCGAATCCGCTCTGCAGAGGGCAGAAAGAAAGCC TTCTCCACGTGTAGTTCCCACCTCACTGTGGTGGGCATCTTCTATGGGACGGGCGTCTTC AGCTACACAAGGCTGGGTTCAGTGGAGTCTTCGGACAAGGACAAGGGCATTGGCATCCTC AACACTGTCATCAGCCCCATGCTGAACCCACTCATCTACTGGACATCTCTGCTGGACGTC GGGTGCATCAGTCACTGTTCCTCCGATGCTGGCGTGTCTCCAGGCCCACCAGTGCAGAGT TCCCTATGCTGCCTGCAGTTCACAGCTCTTCTTTCCCCACCTCCTGGCTGGGGTGGACTG TCACCTCTTAATAGCCATGGCCTA |
| Conceptual translation |
MDLGNSGNDSVVTKFVLLGLTETAALQPILFVIFLLAYVTTIGGTLSILAAILMETKLHS PMYFFLGNLSLPDVGCVSVTVPAMLSHFISNDRSIPYKACLSELFFFHLLAGADCFLLTI MAYDRYLAICQSLTYSSRMSWGIQQALVGMSCVFSFTNALTQTVALSPLNFCGPNVINHF YCDLPQPFQLSCSSVHLNGQLLFVAAAFMGVAPLVLITVSYAHVAAAVLRIRSAEGRKKA FSTCSSHLTVVGIFYGTGVFSYTRLGSVESSDKDKGIGILNTVISPMLNPLIYWTSLLDV GCISHCSSDAGVSPGPPVQSSLCCLQFTALLSPPPGWGGLSPLNSHGL Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 17 | 100 | -100 | NS | A/G | I/V | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 17 | 100 | -100 | SYN | C/T | V/V | 1000GP (YRI, YRI, YRI, YRI) |
| 17 | 3,213,690 | 3,213,690 | NS | C/T | T/I | rs61734050 (DbSNP) |
| 17 | 3,213,728 | 3,213,728 | NS | A/G | I/V | rs9905684 (DbSNP) |
| 17 | 3,213,835 | 3,213,835 | SYN | C/T | V/V | rs60491901 (DbSNP) |
| 17 | 3,213,841 | 3,213,841 | SYN | C/T | V/V | rs61734052 (DbSNP) |
| 17 | 3,213,862 | 3,213,862 | NS | C/G | S/R | rs9905086 (DbSNP) |
| 17 | 3,213,892 | 3,213,892 | SYN | C/G | P/P | rs41425144 (DbSNP) |
| 17 | 3,213,911 | 3,213,911 | NS | C/G | Q/E | rs9903671 (DbSNP) |
| 17 | 3,213,962 | 3,213,962 | NS | A/G | I/V | rs9906179 (DbSNP) |
| 17 | 3,213,994 | 3,213,994 | SYN | C/T | C/C | rs57698364 (DbSNP) |
| 17 | 3,214,106 | 3,214,106 | NS | A/C | T/P | rs9911226 (DbSNP) |
| 17 | 3,214,128 | 3,214,128 | NS | A/G | N/S | rs9912090 (DbSNP) |
| 17 | 3,214,145 | 3,214,145 | NS | T/C | Y/H | rs2855677 (DbSNP) |
| 17 | 3,214,181 | 3,214,181 | NS | G/T | A/S | rs231678 (DbSNP) |
| 17 | 3,214,299 | 3,214,299 | NS | A/G | H/R | rs61734049 (DbSNP) |
| 17 | 3,214,314 | 3,214,314 | NS | A/G | K/R | rs231677 (DbSNP) |
| 17 | 3,214,502 | 3,214,502 | NS | A/G | I/V | rs8076130 (DbSNP) |
| 17 | 3,214,544 | 3,214,544 | NS | A/C | T/P | rs62089558 (DbSNP) |
| 17 | 3,214,546 | 3,214,546 | SYN | A/T | P/P | rs60532712 (DbSNP) |
| 17 | 3,310,396 | 3,310,396 | NS | T/C | I/T | 1000GP (CEU, CHBJPT) |
| 17 | 3,310,434 | 3,310,434 | NS | A/G | I/V | 1000GP (CEU) |
| 17 | 3,310,568 | 3,310,568 | NS | C/G | S/R | 1000GP (CEU) |
| 17 | 3,310,617 | 3,310,617 | NS | G/C | E/Q | 1000GP (CEU) |
| 17 | 3,310,668 | 3,310,668 | NS | A/G | I/V | 1000GP (CEU) |
| 17 | 3,310,812 | 3,310,812 | NS | C/A | P/T | 1000GP (CEU) |
| 17 | 3,310,834 | 3,310,834 | NS | A/G | N/S | 1000GP (CEU) |
| 17 | 3,310,887 | 3,310,887 | NS | T/G | S/A | 1000GP (CEU, CHBJPT) |
| 17 | 3,311,020 | 3,311,020 | NS | G/A | R/K | 1000GP (CEU) |
| 17 | 3,311,208 | 3,311,208 | NS | G/A | V/I | 1000GP (CHBJPT) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 44 (Hasin) | |||
| 17 | 3,213,505 | 3,216,648 | CopyNumber | #99 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| I29T | I42V | V81I | S86R | E103Q | T119S | I120V | R125H | P168T | N175S | Y181H | S193A | R237K | V300I | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | I | I | V | S | E | T | I | R | P | N | Y | S | R | V | 39.02 | 1.000 |
| 2 | I | I | V | S | E | T | I | R | P | N | Y | A | R | V | 26.34 | 1.000 |
| 3 | T | I | V | S | E | T | I | R | P | N | Y | A | R | V | 10.52 | 1.000 |
| 4 | I | V | V | R | Q | T | V | R | T | S | Y | S | R | V | 9.06 | 1.000 |
| 5 | I | V | V | R | Q | T | V | R | T | S | Y | S | R | I | 4.92 | 1.000 |
| 6 | I | V | V | R | Q | T | V | R | T | N | H | S | R | V | 2.76 | 1.000 |
| 7 | I | I | V | S | E | T | I | R | P | N | Y | A | K | V | 2.15 | 1.000 |
| 8 | I | V | V | R | Q | T | V | R | T | S | Y | S | K | I | 0.77 | 1.000 |
| 9 | I | V | V | R | Q | T | V | R | T | S | Y | A | K | I | 0.38 | 1.000 |
| 10 | I | V | V | R | Q | T | I | R | T | S | Y | S | R | V | 0.38 | 1.000 |
| 11 | I | I | V | S | E | T | I | R | P | N | H | S | R | V | 0.38 | 1.000 |
| 12 | I | I | V | S | E | T | I | H | P | N | Y | S | R | V | 0.31 | 1.000 |
| 13 | T | I | V | S | E | T | I | R | P | N | Y | S | R | V | 0.31 | 1.000 |
| 14 | I | I | V | S | E | T | I | R | P | N | Y | S | R | I | 0.23 | 1.000 |
| 15 | I | I | V | S | E | T | V | R | T | S | Y | S | R | V | 0.23 | 1.000 |
| 16 | I | V | V | R | Q | T | V | R | T | N | Y | A | R | V | 0.15 | 1.000 |
| 17 | I | V | V | R | Q | T | I | R | P | S | Y | S | R | V | 0.15 | 1.000 |
| 18 | I | I | V | S | E | T | I | R | P | S | Y | A | R | V | 0.15 | 1.000 |
| 19 | I | V | V | S | E | T | I | R | P | N | Y | S | R | V | 0.15 | 1.000 |
| 20 | I | V | V | R | Q | T | I | R | P | N | Y | A | R | V | 0.15 | 1.000 |
| 21 | I | V | V | R | Q | T | V | R | T | S | Y | A | R | V | 0.15 | 1.000 |
| 22 | I | I | V | R | Q | T | I | R | P | N | Y | S | R | V | 0.08 | 1.000 |
| 23 | I | I | V | S | Q | T | V | R | T | S | Y | S | R | V | 0.08 | 1.000 |
| 24 | I | V | V | R | Q | T | V | H | T | S | Y | S | R | I | 0.08 | 1.000 |
| 25 | I | I | V | R | Q | T | I | R | P | N | Y | A | R | V | 0.08 | 1.000 |
| 26 | I | V | V | R | Q | T | V | R | T | S | Y | A | R | I | 0.08 | 1.000 |
| 27 | I | V | V | S | E | T | I | R | T | S | Y | S | K | V | 0.08 | 1.000 |
| 28 | I | I | V | R | E | T | I | R | T | S | Y | S | R | V | 0.08 | 1.000 |
| 29 | I | V | V | R | Q | T | V | R | P | N | Y | S | R | V | 0.08 | 1.000 |
| 30 | I | V | V | S | E | T | V | R | T | S | Y | S | R | I | 0.08 | 1.000 |
| 31 | I | I | I | S | E | T | I | R | P | N | Y | A | R | V | 0.08 | 1.000 |
| 32 | I | V | I | R | Q | T | I | R | P | N | Y | A | R | V | 0.08 | 1.000 |
| 33 | I | V | V | S | E | T | I | R | T | S | Y | S | R | V | 0.08 | 1.000 |
| 34 | I | I | V | S | E | S | I | R | P | N | Y | S | R | V | 0.08 | 1.000 |
| 35 | I | I | V | R | E | T | I | R | T | N | Y | A | R | V | 0.08 | 1.000 |
| 36 | I | I | V | S | E | T | I | R | T | S | Y | S | R | I | 0.08 | 1.000 |
| 37 | I | V | V | R | Q | T | V | R | T | N | H | A | R | V | 0.08 | 1.000 |
| 38 | I | V | V | S | Q | T | V | R | T | N | Y | A | R | V | 0.08 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR3A4.aApr07-unspliced | main_exon | 5UTR | chr17 | 3,309,986 | 3,310,311 | + |
| CDS | chr17 | 3,310,311 | 3,311,354 | + | ||
| 3UTR | chr17 | 3,311,354 | 3,311,357 | + | ||