OR4C46 Olfactory Receptor
| Gene Symbol | OR4C461 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | 1 (pseudogene) |
| Aliases | HsOR11.10.8 |
| External Ids | HGNC: 31271 GeneBank: NM_001004703 |
| Build #39 labels | |
| Chromosomal location | 11:54,603,071-54,603,997 (+) |
| Cluster | 11@51 |
| Synteny | CLIC#26 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4C10P | 94.82% | 309 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4C10 | 86% | 309 |
| Dog | OR4C10C | 85% | 309 |
| Mouse | Or4c10 | 85% | 304 |
| Rat | Or4c105 | 79% | 309 |
| Cow | OR4C10G | 83% | 307 |
| Cow | OR4C10 | 83% | 305 |
| Orang | OR4C9P | 83% | 309 |
| Horse | OR4C10 | 82% | 308 |
| Chimp | OR4C10P | 94% | 309 |
| Chimp | OR4C46P | 93% | 307 |
Sequence information
| Nucleotide sequence |
ATGGAGAATAGGAATAACATGACAGAGTTTGTTTTGCTGGGGCTTACAGAGAATCCAAAG ATGCAGAAAATCATATTTGTTGTGTTTTTTGTCATCTATATCATCACTGTGGTGGGATAT GTGCTCATTGTGGTCACCATCACTGCCAGCCCATCACTGGGGTCCCCCATGTACCTTTCC CTGGCCTATCTCTCCTTTATTGATGCCTGCTATTCCTCTGTCAATACCCCTAACCTGATC ACACATTCACTCTATGGAAAGAAGGCCATCCTATTCAATGGATGCATGACTCAAGTCTTT GGAGAACATTTCTTCGGAGGTGCAGAGGGCATCCTACTTACTGTGATGGCCTATGACCAC TATGTGGCCATCTGCAAGCCCTTGCACTATATGACTATCATGAACCAGTGTGTGTGTGCC CTGCTAATGGGAGTGGTGTGGATGGGAGGCTTTCTTCATGCAACCATACAGATCCTCTTC ATCTTCCAATTACCTTTCTGTGGTCCTAATGTCATAGATCACTTTATGTGTGATCTGAAC CCTTTGCTCAACCTCGCCTGCACTGACACCCATATGCTGGAACTCTTCATTGCTGCCAAC AGTGGATTCATCTGCTTGTTAAACTTTGCCCTCCTGCTGGTCTCCTATGTGGTCATCTTG TGCTCCCTAAGGACTCATAGCTTGGAGGCAAGGCACAAAGCCCTCTCCACCTGTGTCTCC CACATCACGGTTGTCATCTTATTCTTTGTGCCCTGCATATTTGTGTACATGAGACCTGCA GCTACTTTACCTATTGATAAAGCAGTTGCTATATTCTACACTATGATAACTCCTATGTTA AACCCCTTAATCTATACCTTGAAGAATGCCCAGATGAAAAATGCCATCAGGAAATTGTGT AGTAGAAAGGACATTTCAGGTGACAAA |
| Conceptual translation |
MENRNNMTEFVLLGLTENPKMQKIIFVVFFVIYIITVVGYVLIVVTITASPSLGSPMYLS LAYLSFIDACYSSVNTPNLITHSLYGKKAILFNGCMTQVFGEHFFGGAEGILLTVMAYDH YVAICKPLHYMTIMNQCVCALLMGVVWMGGFLHATIQILFIFQLPFCGPNVIDHFMCDLN PLLNLACTDTHMLELFIAANSGFICLLNFALLLVSYVVILCSLRTHSLEARHKALSTCVS HITVVILFFVPCIFVYMRPAATLPIDKAVAIFYTMITPMLNPLIYTLKNAQMKNAIRKLC SRKDISGDK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 51,515,834 | 51,515,834 | NS | A/C | I/L | rs61890422 (DbSNP) |
| 11 | 51,516,144 | 51,516,144 | NS | A/G | K/R | rs11246609 (DbSNP) |
| 11 | 51,516,036 | 51,516,036 | NS | A/G | Y/C | rs11246608 (DbSNP) |
| 11 | 51,515,546 | 51,515,546 | NS | A/G | T/A | rs61890419 (DbSNP) |
| 11 | 51,515,460 | 51,515,460 | NS | C/T | S/F | rs11246606 (DbSNP) |
| 11 | 51,516,000 | 51,516,000 | NS | C/T | S/F | rs11246607 (DbSNP) |
| 11 | 51,515,830 | 51,515,830 | SYN | C/G | L/L | rs61890421 (DbSNP) |
| 11 | 51,515,596 | 51,515,596 | SYN | C/T | F/F | rs61890420 (DbSNP) |
| 11 | 54,603,367 | 54,603,367 | NS | C/T | L/F | 1000GP (CEU, CHBJPT) |
| 11 | 54,603,819 | 54,603,819 | NS | C/T | S/F | 1000GP (CEU) |
| 11 | 54,603,135 | 54,603,135 | NS | A/G | K/R | 1000GP (CEU) |
| 11 | 54,603,325 | 54,603,325 | NS | A/T | T/S | 1000GP (CEU) |
| 11 | 100 | -100 | NS | C/T | S/F | 1000GP (YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 51,192,824 | 51,563,636 | CopyNumber | Variation_8689 (DGV) |
| 11 | 51,228,146 | 51,525,878 | CopyNumber | Variation_48823 (DGV) |
| 11 | 51,372,036 | 51,529,002 | CopyNumber | Variation_53111 (DGV) |
| 11 | 51,515,182 | 51,518,208 | Deletion | #274 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| S60F | A89T | A108V | H120R | A199T | L211F | T225S | A234V | L235H | C238R | S240F | D304N | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | S | A | A | H | A | L | T | A | L | C | F | D | 44.85 | 1.000 |
| 2 | S | A | A | H | A | L | T | A | L | C | S | D | 32.87 | 1.000 |
| 3 | F | A | A | R | A | F | T | A | L | C | S | D | 12.44 | 1.000 |
| 4 | F | T | A | H | A | L | T | A | L | C | S | D | 3.53 | 1.000 |
| 5 | S | A | A | H | A | L | T | A | L | R | S | D | 1.15 | 1.000 |
| 6 | F | A | A | H | A | F | T | A | L | C | S | D | 1.08 | 1.000 |
| 7 | S | A | A | R | A | F | T | A | L | C | S | D | 0.92 | 1.000 |
| 8 | F | A | A | R | A | F | T | V | L | C | S | D | 0.77 | 1.000 |
| 9 | S | A | A | H | A | L | T | A | L | C | F | N | 0.54 | 1.000 |
| 10 | S | T | A | H | A | L | T | A | L | C | S | D | 0.31 | 1.000 |
| 11 | S | A | V | H | A | L | T | A | L | C | F | D | 0.23 | 1.000 |
| 12 | S | A | A | H | A | L | S | A | L | C | F | D | 0.23 | 1.000 |
| 13 | S | A | A | H | A | L | T | A | H | C | S | D | 0.15 | 1.000 |
| 14 | F | A | A | H | A | L | T | A | L | C | S | D | 0.15 | 1.000 |
| 15 | S | A | A | R | A | L | T | A | L | C | S | D | 0.15 | 1.000 |
| 16 | F | T | A | H | A | L | T | A | H | C | S | D | 0.15 | 1.000 |
| 17 | S | A | A | H | A | L | T | A | L | R | F | D | 0.08 | 1.000 |
| 18 | S | A | A | H | T | L | T | A | L | C | F | D | 0.08 | 1.000 |
| 19 | S | A | A | H | A | F | T | A | L | C | S | D | 0.08 | 1.000 |
| 20 | S | A | A | R | A | L | T | A | L | C | F | D | 0.08 | 1.000 |
| 21 | S | A | A | H | A | L | T | A | H | C | F | D | 0.08 | 1.000 |
| 22 | S | T | A | H | A | L | T | A | L | C | F | D | 0.08 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4C46.aApr07-unspliced | main_exon | 3UTR | chr11 | 54,603,068 | 54,603,071 | + |
| CDS | chr11 | 54,603,071 | 54,603,997 | + | ||