OR4C5 Olfactory Receptor

Gene Symbol	OR4C5¹ (View this gene in GeneCards)
Family	4
Subfamily	C
Pseudogene	No
CORP pseudogene probability score	0.39 (functional)
Aliases	OR11-99, HsOR11.8.9
External Ids	HGNC: 14702 GeneBank: AB065910, BK004350, NG_002247
Build #39 labels	OR4C5P
Chromosomal location	11:48,365,488-48,366,465 (-)
Cluster	11@48
Synteny	CLIC#26
Remarks

Most Similar ORs in Humans (Paralogs)

Symbol	Percent	Length
OR4C48P	85.39%	308

Most Similar ORs in other species (Orthologs)

Specie	Symbol	Percent	Length
Dog	OR4C58	68%	299
Mouse	Or4c35	77%	301
Rat	Or4c35	78%	301
Cow	OR4C5P	76%	307
Orang	OR4C9P	62%	298
Horse	OR4C202	74%	309
Chimp	OR4C5P	95%	328

Sequence information

Nucleotide sequence

ATGTATGTGTCAAATTGCAATCCTTGTGCTATTCACAGAAAAATCAATTATCCAAATACC
AAACTGGATTTCGAGCAAGTGAACAACATAACGGAATTCATCTTGCTTGGCCTGACACAG
AACGCAGAGGCACAGAAACTCTTGTTTGCTGTGTTTACACTCATCTACTTTCTCACCATG
GTAGACAACCTAATCATTGTGGTGACAATCACCACCAGCCCAGCCCTGGACTCCCCCGTG
TATTTTTTTCTGTCTTTCTTTTCCTTCATAGATGGCTGCTCCTCTTCTACCATGGCCCCC
AAAATGATATTTGACTTACTCACTGAAAAGAAAACTATTTCCTTCAGTGGGTGCATGACC
CAGCTCTTTGTAGAACATTTCTTTGGGGGAGTTGAGATCATTCTGCTCGTGGTGATGGCC
TATGACTGCTATGTGGCCATCTGCAAGCCCCTGTACTACCTGATCACAATGAACAGGCAG
GTATGTGGCCTCCTGGTGGCCATGGCATGGGTCGGGGGATTTCTTCACGCTCTGATTCAA
ATGCTTTTAATAGTCTGGCTGCCCTTCTGTGGCCCCAATGTCATTGACCATTTCATCTGT
GACCTTTTCCCTCTGCTAAAACTCTCCTGCACTGACACTCACGTCTTTGGACTCTTTGTT
GCCGCCAACAGTGGGCTGATGTGTATGCTCATTTTTTCTATTCTTATTACCTCTTACGTC
CTAATCCTCTGCTCACAGCGGAAGGCTCTCTCTACCTGCGCCTTCCATATCACTGTAGTC
GTCCTATTCTTTGTTCCCTGTATATTGGTGTACCTTCGACCCATGATCACCTTCCCTATT
GATAAAGCTGTGTCTGTGTTTTATACTGTGGTAACACCCATGTTAAACCCTTTAATCTAC
ACCCTCAGAAACACAGAGGTGAAAAATGCCATGAAGCAGCTCTGGAGCCAAATAATCTGG
GGTAACAATTTGTGTGAT

Conceptual translation

MYVSNCNPCAIHRKINYPNTKLDFEQVNNITEFILLGLTQNAEAQKLLFAVFTLIYFLTM
VDNLIIVVTITTSPALDSPVYFFLSFFSFIDGCSSSTMAPKMIFDLLTEKKTISFSGCMT
QLFVEHFFGGVEIILLVVMAYDCYVAICKPLYYLITMNRQVCGLLVAMAWVGGFLHALIQ
MLLIVWLPFCGPNVIDHFICDLFPLLKLSCTDTHVFGLFVAANSGLMCMLIFSILITSYV
LILCSQRKALSTCAFHITVVVLFFVPCILVYLRPMITFPIDKAVSVFYTVVTPMLNPLIY
TLRNTEVKNAMKQLWSQIIWGNNLCD

Protein domains and features

Variations - SNPs

Chr	Start	End	Type	Variation	AA Change	SNP IDs
11	48,387,684	48,387,684	Del(1)	-/T		rs67755516 (DbSNP)
11	48,387,918	48,387,918	Del(1)	-/T		rs66829866 (DbSNP)
11	48,387,692	48,387,692	Del(1)	-/T		rs66509342 (DbSNP)
11	48,387,947	48,387,946	Ins(2)	-/CA		rs67722745 (DbSNP)
11	48,387,949	48,387,948	Ins(2)	-/TA		rs35173607 (DbSNP)
11	48,387,850	48,387,850	nonsense SNP	G/T	Y/*	rs73460781 (DbSNP)
11	48,387,284	48,387,284	nonsense SNP	T/G	*/S	rs71220565 (DbSNP)
11	48,387,335	48,387,335	NS	A/C	F/C	rs73460769 (DbSNP)
11	48,387,186	48,387,186	NS	A/G	F/L	rs1994140 (DbSNP)
11	48,387,164	48,387,164	NS	A/G	F/S	rs72473371 (DbSNP)
11	48,387,506	48,387,506	NS	A/G	V/A	rs72898882 (DbSNP)
11	48,387,668	48,387,668	NS	C/G	G/A	rs10769651 (DbSNP)
11	48,387,737	48,387,737	NS	C/G	C/S	rs73460780 (DbSNP)
11	48,387,630	48,387,630	NS	C/T	G/R	rs73460777 (DbSNP)
11	48,387,275	48,387,275	NS	C/T	R/K	rs10838881 (DbSNP)
11	48,387,354	48,387,354	NS	C/T	A/T	rs73460771 (DbSNP)
11	48,387,237	48,387,237	NS	C/T	V/I	rs72898877 (DbSNP)
11	48,387,284	48,387,284	NS	G/A	S/L	rs10839482 (DbSNP)
11	48,387,424	48,387,424	NS	G/T	F/L	rs61917478 (DbSNP)
11	48,387,540	48,387,540	NS	G/T	Q/K	rs72898885 (DbSNP)
11	48,387,705	48,387,705	NS	T/C	N/D	rs34926479 (DbSNP)
11	48,387,155	48,387,155	NS	T/C	Y/C	rs10839483 (DbSNP)
11	48,387,154	48,387,154	SYN	A/G	Y/Y	rs72473370 (DbSNP)
11	48,387,370	48,387,370	SYN	A/G	F/F	rs73460772 (DbSNP)
11	48,387,244	48,387,244	SYN	A/T	T/T	rs7130061 (DbSNP)
11	48,387,604	48,387,604	SYN	C/T	V/V	rs72898886 (DbSNP)
11	48,387,535	48,387,535	SYN	C/T	V/V	rs72898883 (DbSNP)
11	48,366,116	48,366,116	NS	C/G	G/A	1000GP (CEU, CHBJPT)
11	48,366,408	48,366,408	NS	T/C	T/A	1000GP (CEU, CHBJPT)
11	48,365,954	48,365,954	NS	A/G	V/A	1000GP (CEU, CHBJPT)
11	48,366,095	48,366,095	NS	A/G	V/A	1000GP (CEU, CHBJPT)
11	48,366,185	48,366,185	NS	G/C	S/C	1000GP (CEU, CHBJPT)
11	48,366,135	48,366,135	NS	T/C	K/E	1000GP (CEU)
11	48,366,367	48,366,367	SYN	G/A	F/F	1000GP (CEU, CHBJPT)
11	48,366,281	48,366,281	NS	T/C	D/G	1000GP (CEU, CHBJPT)
11	48,366,237	48,366,237	NS	C/G	D/H	1000GP (CEU, CHBJPT)
11	48,365,938	48,365,938	SYN	G/A	H/H	1000GP (CEU, CHBJPT)
11	48,366,127	48,366,127	SYN	A/G	I/I	1000GP (CEU, CHBJPT)
11	48,365,988	48,365,988	NS	G/T	Q/K	1000GP (CEU)
11	48,366,205	48,366,205	NS	A/C	F/L	1000GP (CEU, CHBJPT)
11	48,366,394	48,366,394	NS	G/T	F/L	1000GP (CEU, CHBJPT)
11	48,366,273	48,366,273	NS	T/G	I/L	1000GP (CEU, CHBJPT)
11	48,365,974	48,365,974	SYN	G/T	L/L	1000GP (CEU, CHBJPT)
11	48,366,228	48,366,228	NS	C/T	V/M	1000GP (CEU, CHBJPT)
11	48,366,153	48,366,153	NS	C/T	D/N	1000GP (CEU, CHBJPT)
11	48,365,723	48,365,723	NS	T/C	K/R	1000GP (CEU, CHBJPT)
11	48,366,137	48,366,137	NS	T/C	K/R	1000GP (CEU, CHBJPT)
11	48,365,555	48,365,555	NS	T/C	N/S	1000GP (CEU, CHBJPT)
11	48,365,563	48,365,563	SYN	G/A	T/T	1000GP (CEU, CHBJPT)
11	48,366,378	48,366,378	NS	T/C	I/V	1000GP (CEU, CHBJPT)
11	48,365,983	48,365,983	SYN	T/C	V/V	1000GP (CEU, CHBJPT)
11	48,366,052	48,366,052	SYN	C/T	V/V	1000GP (CEU, CHBJPT)
11	48,365,727	48,365,727	NS	G/A	R/W	1000GP (CEU, CHBJPT)
11	48,365,566	48,365,566	SYN	G/A	Y/Y	1000GP (CEU, CHBJPT)
11	48,365,546	48,365,546	NS	A/C	V/G	1000GP (CHBJPT)
11	48,365,685	48,365,685	NS	C/T	V/I	1000GP (CHBJPT)
11	48,365,686	48,365,686	SYN	G/A	V/V	1000GP (CHBJPT)
11	48,365,732	48,365,732	nonsense SNP	G/C	S/*	1000GP (CHBJPT)
11	48,365,749	48,365,749	SYN	G/A	Y/Y	1000GP (CHBJPT)
11	48,365,783	48,365,783	NS	C/A	C/F	1000GP (CHBJPT)
11	48,366,078	48,366,078	NS	C/T	G/R	1000GP (CHBJPT)
11	48,366,338	48,366,338	NS	T/C	E/G	1000GP (CHBJPT)
11	48,366,342	48,366,342	NS	C/T	A/T	1000GP (CHBJPT)
11	48,366,348	48,366,348	nonsense SNP	G/A	Q/*	1000GP (CHBJPT)
11	48,366,426	48,366,426	nonsense SNP	T/A	K/*	1000GP (CHBJPT)
11	48,366,431	48,366,431	NS	T/C	H/R	1000GP (CHBJPT)
11	100	-100	NS	A/C	V/G	1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI)
11	100	-100	SYN	G/A	T/T	1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI)
11	100	-100	nonsense SNP	G/T	Y/*	1000GP (YRI, YRI, YRI)

Variations - CNVs

Chr	Start	End	Type	Sources
11	48,365,757	49,068,634	CopyNumber	Variation_2922 (DGV)
11	48,303,671	48,863,606	CopyNumber	Variation_3848 (DGV)
11	48,346,202	48,972,502	CopyNumber	Variation_9183 (DGV)
			CopyNumber	34 (Hasin)
11	48,385,040	48,388,117	CopyNumber	#176 (Waszak)
11	48,387,127	48,387,354	Ins(16)	#6(modil)

Haplotypes

Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.

	F278L	L269F	V145E	C143Y	G117A	D77H	I55V	A42T	Q40*	T20A	% Freq	CORP
1	F	L	V	C	G	D	I	A	Q	T	11.83	0.674
2	L	L	V	C	G	D	I	A	Q	T	7.91	0.674
3	F	L	V	C	G	H	I	A	Q	T	6.91	0.674
4	L	L	V	C	G	H	I	A	Q	T	6.45	0.674
5	F	F	V	C	G	H	I	A	Q	T	3.61	0.674
6	F	F	V	C	G	D	I	A	Q	T	3.53	0.674
7	L	L	V	C	G	D	I	T	*	A	3.00	1.200
8	L	L	V	C	G	H	I	T	*	A	2.92	1.200
9	F	L	V	C	A	D	I	A	Q	T	2.92	0.674
10	F	L	V	C	A	H	I	A	Q	T	2.92	0.674
11	F	L	V	C	G	H	I	T	*	A	2.46	1.200
12	F	L	V	C	G	D	I	T	*	A	2.23	1.200
13	F	F	V	C	G	D	I	T	*	A	1.54	1.200
14	F	F	E	C	A	H	I	A	Q	T	1.38	0.674
15	F	L	V	C	G	H	I	A	Q	A	1.38	0.674
16	F	F	V	C	G	H	I	T	*	A	1.31	1.200
17	F	L	V	C	G	D	I	T	*	T	1.23	1.200
18	F	F	V	C	A	D	I	A	Q	T	1.23	0.674
19	F	L	V	C	G	D	I	A	Q	A	1.23	0.674
20	F	L	V	C	A	D	I	T	*	A	1.15	1.200
21	F	F	V	C	A	H	I	A	Q	T	1.08	0.674
22	F	F	V	C	G	H	I	T	*	T	1.00	1.200
23	L	L	V	C	G	H	I	T	*	T	0.92	1.200
24	L	L	V	C	G	D	I	T	*	T	0.92	1.200
25	F	L	V	C	A	D	I	A	Q	A	0.92	0.674
26	F	F	E	C	G	D	I	A	Q	T	0.92	0.674
27	F	L	V	C	G	H	I	T	*	T	0.92	1.200
28	F	L	V	C	A	H	I	T	*	A	0.92	1.200
29	L	L	V	C	G	D	I	A	Q	A	0.84	0.674
30	F	F	E	C	G	D	I	T	*	A	0.84	1.200
31	F	F	V	C	G	H	I	A	Q	A	0.84	0.674
32	F	L	E	C	G	D	I	A	Q	T	0.84	0.674
33	F	F	E	C	A	D	I	T	*	A	0.77	1.200
34	F	F	V	C	A	D	I	T	*	A	0.77	1.200
35	F	F	V	C	G	D	I	A	Q	A	0.69	0.674
36	F	F	V	C	A	H	I	T	*	A	0.69	1.200
37	L	L	V	C	A	D	I	A	Q	T	0.69	0.674
38	F	F	E	C	G	H	I	A	Q	T	0.69	0.674
39	F	F	E	C	A	D	I	A	Q	T	0.61	0.674
40	L	L	V	C	A	H	I	T	*	A	0.61	1.200
41	L	L	V	C	G	H	I	A	Q	A	0.61	0.674
42	F	L	E	C	G	H	I	A	Q	T	0.54	0.674
43	F	F	E	C	A	H	I	T	*	A	0.54	1.200
44	L	L	V	C	A	H	I	A	Q	T	0.54	0.674
45	L	F	V	C	G	D	I	T	*	T	0.46	1.200
46	F	F	E	C	G	H	I	T	*	A	0.46	1.200
47	F	L	E	C	G	D	I	A	Q	A	0.46	0.674
48	F	L	V	C	G	D	V	A	Q	T	0.46	0.674
49	F	L	V	C	A	H	I	A	Q	A	0.38	0.674
50	L	F	V	C	G	D	I	A	Q	T	0.38	0.674
51	F	L	E	C	A	H	I	A	Q	T	0.38	0.674
52	F	L	V	C	G	D	I	T	Q	T	0.38	0.674
53	F	L	E	C	A	D	I	T	*	A	0.31	1.200
54	F	L	V	C	A	H	I	T	*	T	0.31	1.200
55	F	L	E	C	A	H	I	T	*	A	0.31	1.200
56	F	F	E	C	G	H	I	T	*	T	0.31	1.200
57	L	L	E	C	G	D	I	A	Q	T	0.31	0.674
58	L	F	V	C	G	H	I	A	Q	T	0.31	0.674
59	F	F	V	C	G	D	I	T	*	T	0.31	1.200
60	F	L	E	C	G	H	I	T	*	A	0.31	1.200
61	F	L	V	C	A	D	I	T	*	T	0.31	1.200
62	L	F	E	C	G	H	I	A	Q	T	0.31	0.674
63	L	F	V	C	G	H	I	T	*	A	0.23	1.200
64	F	F	V	C	A	D	V	A	Q	T	0.23	0.674
65	L	L	V	C	A	D	I	T	*	A	0.23	1.200
66	L	L	V	C	A	D	I	A	Q	A	0.23	0.674
67	F	F	V	C	A	H	I	A	Q	A	0.23	0.674
68	L	F	V	C	G	H	I	A	Q	A	0.23	0.674
69	L	L	V	C	A	H	I	A	Q	A	0.15	0.674
70	F	F	V	C	A	H	I	T	*	T	0.15	1.200
71	F	L	E	C	A	D	I	A	Q	T	0.15	0.674
72	L	L	E	C	G	D	I	T	*	T	0.15	1.200
73	L	F	V	C	A	D	I	A	Q	T	0.15	0.674
74	L	L	V	C	A	H	I	T	*	T	0.15	1.200
75	L	L	E	C	G	H	I	A	Q	T	0.15	0.674
76	F	L	E	C	G	H	I	T	*	T	0.15	1.200
77	F	F	V	C	G	H	I	T	Q	T	0.15	0.674
78	L	F	V	C	G	D	I	A	Q	A	0.15	0.674
79	L	L	V	C	G	D	I	T	Q	T	0.15	0.674
80	L	F	V	C	A	H	I	T	*	T	0.15	1.200
81	L	L	V	C	A	D	I	T	*	T	0.15	1.200
82	L	L	E	C	G	H	I	A	Q	A	0.15	0.674
83	F	F	E	C	A	H	I	A	Q	A	0.15	0.674
84	L	L	E	C	G	D	I	A	Q	A	0.15	0.674
85	L	L	V	C	G	H	I	T	Q	T	0.15	0.674
86	F	F	V	C	G	H	V	A	Q	T	0.15	0.674
87	F	L	V	C	G	H	V	A	Q	T	0.15	0.674
88	L	L	V	Y	G	H	I	A	Q	T	0.15	0.674
89	F	L	E	C	G	H	V	A	Q	T	0.08	0.674
90	F	L	E	C	A	D	I	T	Q	T	0.08	0.674
91	L	L	V	Y	A	D	I	T	*	A	0.08	1.200
92	F	F	V	C	G	D	I	T	Q	T	0.08	0.674
93	L	F	V	Y	G	D	I	T	*	T	0.08	1.200
94	F	L	E	C	A	D	I	A	Q	A	0.08	0.674
95	L	F	V	C	A	H	I	T	*	A	0.08	1.200
96	F	L	V	C	G	H	I	T	Q	T	0.08	0.674
97	F	L	V	C	G	D	I	T	Q	A	0.08	0.674
98	F	F	V	C	A	D	I	T	*	T	0.08	1.200
99	F	F	E	C	A	D	I	T	*	T	0.08	1.200
100	F	L	E	C	G	H	I	A	Q	A	0.08	0.674
101	L	F	E	C	G	D	I	T	*	T	0.08	1.200
102	L	F	V	C	A	H	I	A	Q	A	0.08	0.674
103	F	L	V	Y	G	D	I	A	Q	T	0.08	0.674
104	L	L	V	C	A	D	I	T	Q	T	0.08	0.674
105	F	F	V	C	A	H	V	A	Q	T	0.08	0.674
106	F	F	E	C	A	H	I	T	Q	T	0.08	0.674
107	F	L	V	Y	G	D	I	A	Q	A	0.08	0.674
108	F	L	V	Y	G	H	I	A	Q	A	0.08	0.674
109	F	L	E	C	G	D	I	T	*	A	0.08	1.200
110	L	F	V	Y	G	H	I	T	*	A	0.08	1.200
111	F	F	V	Y	G	H	I	T	*	T	0.08	1.200
112	L	F	V	C	A	D	I	T	*	T	0.08	1.200
113	L	L	E	C	A	H	I	A	Q	A	0.08	0.674
114	L	L	V	C	G	H	V	A	Q	T	0.08	0.674
115	F	L	V	C	G	D	I	A	*	A	0.08	1.200
116	L	L	V	C	G	D	V	A	Q	T	0.08	0.674
117	F	F	V	C	A	H	I	A	*	A	0.08	1.200
118	L	L	E	C	A	H	I	T	*	A	0.08	1.200
119	L	L	V	Y	G	H	I	T	*	T	0.08	1.200
120	F	L	V	Y	G	H	I	A	Q	T	0.08	0.674
121	F	L	V	C	G	H	I	A	*	A	0.08	1.200
122	F	L	E	C	G	D	I	T	Q	A	0.08	0.674
123	F	F	V	Y	G	D	I	T	*	T	0.08	1.200
124	L	L	E	C	G	H	I	T	*	T	0.08	1.200
125	L	L	E	C	G	D	I	T	*	A	0.08	1.200
126	L	L	V	C	A	D	V	A	Q	T	0.08	0.674
127	F	L	V	C	A	D	V	A	Q	T	0.08	0.674
128	L	F	V	C	A	D	I	A	Q	A	0.08	0.674
129	F	F	E	C	A	H	I	T	*	T	0.08	1.200
130	L	F	V	C	A	H	I	A	Q	T	0.08	0.674

HORDE

Search Olfactory receptors