OR4E2 Olfactory Receptor
| Gene Symbol | OR4E21 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | E |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR14-42, AE000658-A, HsOR14.2.5, ORL3698 |
| External Ids | HGNC: 8297 GeneBank: AB065895, AF399581, AY726598, BK004526, NM_001001912 ORDB: ORL3698 |
| Build #39 labels | OR4E2 |
| Chromosomal location | 14:21,665,083-21,666,021 (+) |
| Cluster | 14@22b |
| Synteny | CLIC#35 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs2874103) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4E1P | 63.16% | 304 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4E1 | 64% | 304 |
| Mouse | Or4e2 | 86% | 306 |
| Rat | Or4e2 | 86% | 306 |
| Cow | OR4E1 | 64% | 302 |
| Orang | OR4E1 | 62% | 303 |
| Horse | OR4E1 | 63% | 301 |
| Chimp | OR4E1 | 63% | 303 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | AB463964 |
| GNF Atlas2 | gnf1h02184_at |
Sequence information
| Nucleotide sequence |
ATGGACAGTCTAAACCAAACAAGAGTGACTGAATTTGTCTTCTTGGGACTCACTGATAAC CGGGTGCTGGAAATGCTGTTTTTCATGGCATTCTCAGCCATTTATATGCTAACGCTTTCA GGGAACATTCTCATCATCATTGCCACAGTCTTTACTCCAAGTCTCCATACCCCCATGTAT TTCTTCCTGAGCAATCTGTCCTTTATTGACATCTGCCACTCATCTGTCACTGTGCCTAAG ATGTTGGAGGGTTTGCTTTTAGAAAGAAAGACCATTTCCTTTGACAACTGCATCACACAG CTCTTCTTCCTACATCTCTTTGCCTGTGCCGAGATCTTTCTGCTGATCATTGTGGCGTAT GATCGTTACGTGGCTATCTGCACTCCACTCCACTACCCCAATGTGATGAACATGAGAGTC TGTATACAGCTTGTCTTTGCTCTCTGGTTGGGGGGTACTGTTCACTCACTAGGGCAGACC TTCTTGACTATTCGTCTACCTTACTGTGGCCCCAACATTATTGACAGCTACTTCTGTGAT GTGCCTCTTGTTATCAAGCTGGCCTGCACAGATACATACCTCACAGGAATACTGATTGTG ACCAATAGTGGAACCATCTCCCTCTCCTGTTTCTTGGCCGTGGTCACCTCCTATATGGTC ATCCTGGTTTCTCTTCGAAAACACTCAGCTGAAGGGCGCCAGAAAGCCCTGTCTACCTGC TCGGCCCACTTCATGGTGGTTGCCCTCTTCTTTGGGCCATGTATCTTCATCTATACTCGG CCAGACACCAGCTTCTCCATTGACAAGGTGGTGTCTGTCTTCTACACAGTGGTCACCCCT TTGCTGAATCCCTTCATTTACACCTTGAGGAATGAGGAGGTAAAAAGTGCCATGAAGCAG CTCAGGCAGAGACAAGTTTTTTTCACGAAATCATATACA |
| Conceptual translation |
MDSLNQTRVTEFVFLGLTDNRVLEMLFFMAFSAIYMLTLSGNILIIIATVFTPSLHTPMY FFLSNLSFIDICHSSVTVPKMLEGLLLERKTISFDNCITQLFFLHLFACAEIFLLIIVAY DRYVAICTPLHYPNVMNMRVCIQLVFALWLGGTVHSLGQTFLTIRLPYCGPNIIDSYFCD VPLVIKLACTDTYLTGILIVTNSGTISLSCFLAVVTSYMVILVSLRKHSAEGRQKALSTC SAHFMVVALFFGPCIFIYTRPDTSFSIDKVVSVFYTVVTPLLNPFIYTLRNEEVKSAMKQ LRQRQVFFTKSYT Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 14 | 100 | -100 | NS | G/A | V/M | 1000GP (YRI, YRI, YRI, YRI) |
| 14 | 100 | -100 | SYN | A/G | S/S | 1000GP (YRI) |
| 14 | 21,665,202 | 21,665,202 | SYN | A/G | S/S | 1000GP (CEU, CHBJPT) |
| 14 | 21,665,412 | 21,665,412 | SYN | C/T | A/A | 1000GP (CEU) |
| 14 | 21,665,434 | 21,665,434 | NS | G/A | V/M | 1000GP (CEU, CHBJPT) |
| 14 | 21,665,685 | 21,665,685 | SYN | C/G | T/T | 1000GP (CEU) |
| 14 | 21,665,783 | 21,665,783 | NS | A/G | Q/R | 1000GP (CEU, CHBJPT) |
| 14 | 21,665,804 | 21,665,804 | NS | C/T | S/L | 1000GP (CEU) |
| 14 | 22,133,416 | 22,133,416 | SYN | A/G | S/S | rs12717305 (DbSNP) |
| 14 | 22,133,648 | 22,133,648 | NS | A/G | M/V | rs2874103 (DbSNP) |
| 14 | 22,133,849 | 22,133,849 | NS | A/G | I/V | rs72686096 (DbSNP) |
| 14 | 22,133,997 | 22,133,997 | NS | A/G | Q/R | rs970382 (DbSNP) |
| 14 | 22,134,018 | 22,134,018 | NS | C/T | S/L | rs61732411 (DbSNP) |
| 14 | 22,134,092 | 22,134,092 | NS | C/T | P/S | rs61732410 (DbSNP) |
| 14 | 22,134,104 | 22,134,104 | NS | G/T | V/L | rs61732409 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 14 | 21,931,624 | 22,169,502 | CopyNumber | Variation_5318 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| F12L | N42H | V118M | R165H | Q234R | L237V | S241L | V270L | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | N | M | R | R | L | S | V | 58.91 | 0.137 |
| 2 | F | N | V | R | Q | L | S | V | 25.12 | 0.388 |
| 3 | F | N | M | R | R | L | L | V | 14.52 | 0.137 |
| 4 | L | N | M | R | R | L | S | V | 0.46 | 0.137 |
| 5 | F | N | M | R | R | L | S | L | 0.46 | 0.137 |
| 6 | F | N | M | R | Q | L | S | V | 0.15 | 0.137 |
| 7 | F | N | V | R | R | L | S | V | 0.15 | 0.388 |
| 8 | F | N | M | R | R | V | L | V | 0.08 | 0.224 |
| 9 | F | N | M | H | R | L | S | V | 0.08 | 0.137 |
| 10 | F | H | M | R | R | L | S | V | 0.08 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4E2.aApr07-unspliced | main_exon | CDS | chr14 | 21,665,083 | 21,666,021 | + |
| 3UTR | chr14 | 21,666,021 | 21,666,024 | + | ||