OR4K5 Olfactory Receptor
| Gene Symbol | OR4K51 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | K |
| Pseudogene | No |
| CORP pseudogene probability score | 0.12 (functional) |
| Aliases | OR14-16, HsOR14.1.12, ORL3684 |
| External Ids | HGNC: 14745 GeneBank: AB065882, BK004355, NM_001005483 ORDB: ORL3684 |
| Build #39 labels | OR4K5 |
| Chromosomal location | 14:19,920,607-19,921,575 (+) |
| Cluster | 14@20b |
| Synteny | CLIC#32 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4K11P | 65.52% | 319 |
| OR4K15 | 68.65% | 319 |
| OR4K8P | 64.89% | 319 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4K5B | 86% | 323 |
| Mouse | Or4k5 | 82% | 323 |
| Rat | Or4k5 | 82% | 319 |
| Cow | OR4K15 | 69% | 311 |
| Orang | OR4K5C | 92% | 324 |
| Orang | OR4K5P | 94% | 312 |
| Orang | OR4K5D | 94% | 287 |
| Horse | OR4K15 | 68% | 320 |
| Chimp | OR4K5P | 95% | 319 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC140947 |
Sequence information
| Nucleotide sequence |
ATGGATAAGTCCAATTCTTCAGTGGTGTCTGAATTTGTACTGTTGGGACTCTGTAGTTCT CAAAAACTCCAGCTTTTCTATTTTTGTTTCTTCTCTGTGTTGTATACAGTCATTGTGCTG GGAAATCTTCTCATTATCCTCACAGTGACTTCTGATACCAGCCTGCACTCCCCTATGTAC TTTCTCTTGGGAAACCTTTCCTTTGTTGACATTTGTCAGGCTTCTTTTGCTACCCCTAAA ATGATTGCAGATTTTCTGAGTGCACACGAGACCATATCTTTCAGTGGCTGCATAGCCCAA ATTTTCTTTATTCACCTTTTTACTGGAGGGGAGATGGTGCTACTTGTTTCGATGGCCTAT GACAGGTATGTAGCCATATGCAAACCCTTATACTATGTGGTCATCATGAGCCGAAGGACA TGCACTGTCTTGGTAATGATCTCCTGGGCTGTGAGCTTGGTGCACACATTAAGCCAGTTA TCATTTACTGTGAACCTGCCTTTTTGTGGACCTAATGTAGTAGACAGCTTTTTTTGTGAT CTTCCTCGAGTCACCAAACTTGCCTGCCTGGACTCTTACATCATTGAAATACTAATTGTG GTCAATAGTGGAATTCTTTCCCTAAGCACTTTCTCTCTCTTGGTCAGCTCCTACATCATT ATTCTTGTTACAGTTTGGCTCAAGTCTTCAGCTGCAATGGCAAAGGCATTTTCTACGCTG GCTTCCCATATTGCAGTAGTAATATTATTCTTTGGACCTTGCATCTTCATCTATGTGTGG CCCTTTACCATCTCTCCTTTGGATAAATTTCTTGCCATATTTTACACTGTTTTCACCCCC GTCCTAAACCCCATTATTTATACACTAAGGAATAGGGATATGAAGGCTGCCGTAAGGAAA ATTGTGAACCATTACCTGAGGCCAAGGAGAATTTCTGAAATGTCACTAGTAGTGAGAACT TCCTTTCAT |
| Conceptual translation |
MDKSNSSVVSEFVLLGLCSSQKLQLFYFCFFSVLYTVIVLGNLLIILTVTSDTSLHSPMY FLLGNLSFVDICQASFATPKMIADFLSAHETISFSGCIAQIFFIHLFTGGEMVLLVSMAY DRYVAICKPLYYVVIMSRRTCTVLVMISWAVSLVHTLSQLSFTVNLPFCGPNVVDSFFCD LPRVTKLACLDSYIIEILIVVNSGILSLSTFSLLVSSYIIILVTVWLKSSAAMAKAFSTL ASHIAVVILFFGPCIFIYVWPFTISPLDKFLAIFYTVFTPVLNPIIYTLRNRDMKAAVRK IVNHYLRPRRISEMSLVVRTSFH Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 14 | 20,389,721 | 20,389,721 | NS | A/G | K/R | rs17242341 (DbSNP) |
| 14 | 19,921,562 | 19,921,562 | NS | G/A | R/K | 1000GP (CEU, CHBJPT) |
| 14 | 19,920,906 | 19,920,906 | SYN | A/G | Q/Q | 1000GP (CHBJPT) |
| 14 | 19,921,447 | 19,921,447 | NS | G/A | V/I | 1000GP (CHBJPT) |
| 14 | 100 | -100 | NS | C/A | N/K | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 14 | 20,197,616 | 20,399,048 | CopyNumber | Variation_0316 (DGV) |
| 14 | 20,371,142 | 20,505,020 | CopyNumber | Variation_2175 (DGV) |
| 14 | 20,203,125 | 20,539,108 | CopyNumber | Variation_3036 (DGV) |
| 14 | 19,662,531 | 20,556,187 | CopyNumber | Variation_3929 (DGV) |
| 14 | 20,219,649 | 20,415,445 | CopyNumber | Variation_4826 (DGV) |
| 14 | 20,362,952 | 20,525,999 | CopyNumber | Variation_4827 (DGV) |
| 14 | 19,117,183 | 20,424,605 | CopyNumber | Variation_7028 (DGV) |
| 14 | 20,203,125 | 20,483,660 | CopyNumber | Variation_8762 (DGV) |
| 14 | 20,203,125 | 20,626,160 | CopyNumber | Variation_8763 (DGV) |
| 14 | 20,239,479 | 20,422,583 | CopyNumber | Variation_8764 (DGV) |
| 14 | 20,203,125 | 20,716,841 | CopyNumber | Variation_8765 (DGV) |
| 14 | 20,203,125 | 20,433,044 | CopyNumber | Variation_9234 (DGV) |
| 14 | 20,239,479 | 20,511,107 | CopyNumber | Variation_9235 (DGV) |
| 14 | 20,177,234 | 20,424,604 | CopyNumber | Variation_30648 (DGV) |
| 14 | 19,360,239 | 20,424,604 | CopyNumber | Variation_31953 (DGV) |
| 14 | 20,203,125 | 20,525,833 | CopyNumber | Variation_34547 (DGV) |
| 14 | 20,267,014 | 20,433,060 | CopyNumber | Variation_34563 (DGV) |
| 14 | 20,203,125 | 20,456,434 | CopyNumber | Variation_34575 (DGV) |
| 14 | 20,203,125 | 20,655,466 | CopyNumber | Variation_34656 (DGV) |
| 14 | 20,239,246 | 20,432,988 | CopyNumber | Variation_34659 (DGV) |
| 14 | 20,203,125 | 20,550,348 | CopyNumber | Variation_34660 (DGV) |
| 14 | 20,203,125 | 20,455,307 | CopyNumber | Variation_34664 (DGV) |
| 14 | 20,200,183 | 20,423,372 | CopyNumber | Variation_38951 (DGV) |
| 14 | 20,305,431 | 20,404,091 | CopyNumber | Variation_49301 (DGV) |
| 14 | 20,305,431 | 20,425,051 | CopyNumber | Variation_49302 (DGV), Variation_49303 (DGV) |
| 14 | 20,305,431 | 20,432,664 | CopyNumber | Variation_49304 (DGV) |
| 14 | 19,349,922 | 20,424,856 | CopyNumber | Variation_58655 (DGV) |
| 14 | 20,177,210 | 20,424,753 | CopyNumber | Variation_66584 (DGV) |
| 14 | 19,781,170 | 20,424,776 | CopyNumber | Variation_71833 (DGV) |
| 14 | 20,289,680 | 20,425,312 | CopyNumber | Variation_71860 (DGV) |
| 14 | 20,152,622 | 20,419,574 | CopyNumber | Variation_76554 (DGV), Variation_87112 (DGV) |
| 14 | 20,326,958 | 20,419,574 | CopyNumber | Variation_76555 (DGV) |
| 14 | 20,283,374 | 20,419,574 | CopyNumber | Variation_76556 (DGV) |
| 14 | 20,386,907 | 20,419,574 | CopyNumber | Variation_76559 (DGV) |
| 14 | 20,299,695 | 20,419,574 | CopyNumber | Variation_87113 (DGV) |
| 14 | 20,348,406 | 20,398,665 | CopyNumber | Variation_101887 (DGV) |
| 14 | 20,388,666 | 20,391,734 | CopyNumber | #164 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| N65K | D70Y | A77V | I92V | H105P | S117L | V259A | W260R | V281I | T288I | R319K | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | N | D | A | I | H | S | V | W | V | T | R | 75.35 | 0.257 |
| 2 | N | D | A | I | H | S | V | W | I | T | K | 15.36 | 0.257 |
| 3 | N | D | A | V | H | S | V | W | V | T | R | 3.07 | 0.365 |
| 4 | N | D | A | I | H | L | V | W | V | T | R | 1.38 | 0.257 |
| 5 | K | D | A | I | H | S | V | R | V | T | R | 1.23 | 0.257 |
| 6 | N | D | A | I | H | S | A | W | V | T | R | 1.08 | 0.257 |
| 7 | N | D | A | I | H | S | V | W | I | T | R | 0.61 | 0.257 |
| 8 | N | Y | A | I | H | S | V | W | V | T | R | 0.38 | 0.752 |
| 9 | N | D | A | I | P | S | V | W | V | T | R | 0.23 | 0.257 |
| 10 | N | D | V | I | H | S | A | W | V | T | R | 0.23 | 0.257 |
| 11 | N | D | A | I | H | S | V | W | V | I | R | 0.23 | 0.257 |
| 12 | N | D | A | V | H | S | V | W | I | T | R | 0.15 | 0.365 |
| 13 | K | D | A | I | H | S | V | W | V | T | R | 0.15 | 0.257 |
| 14 | N | D | A | V | H | L | V | W | V | T | R | 0.08 | 0.365 |
| 15 | N | D | A | I | H | S | V | W | V | T | K | 0.08 | 0.257 |
| 16 | N | D | A | I | H | S | A | W | I | T | K | 0.08 | 0.257 |
| 17 | N | D | A | I | H | S | V | W | I | I | K | 0.08 | 0.257 |
| 18 | N | D | A | I | H | S | V | W | I | I | R | 0.08 | 0.257 |
| 19 | N | Y | A | I | H | S | V | W | I | T | K | 0.08 | 0.752 |
| 20 | N | D | A | I | P | S | A | W | V | T | R | 0.08 | 0.257 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4K5.aApr07-unspliced | main_exon | CDS | chr14 | 19,920,607 | 19,921,575 | + |
| 3UTR | chr14 | 19,921,575 | 19,921,578 | + | ||