OR4N4 Olfactory Receptor
| Gene Symbol | OR4N41 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | N |
| Pseudogene | No |
| CORP pseudogene probability score | 1 (pseudogene) |
| Aliases | OR15-5, OR15-1, HsOR15.1.9, ORL3721, ORL3722 |
| External Ids | HGNC: 15375 GeneBank: AB065653, AB065904, BK004406, BK004479, NM_001005241 ORDB: ORL3721, ORL3722 |
| Build #39 labels | OR4N4 |
| Chromosomal location | 15:22,094,522-22,095,469 (+) |
| Cluster | 15@22 |
| Synteny | CLIC#32 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4N1P | 93.95% | 314 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4N2B | 88% | 308 |
| Dog | OR4N2 | 86% | 305 |
| Mouse | Or4n4 | 85% | 308 |
| Rat | Or4n4 | 82% | 308 |
| Rat | Or4n5 | 82% | 308 |
| Cow | OR4N2C | 89% | 306 |
| Cow | OR4N2 | 86% | 306 |
| Orang | OR4N1P | 94% | 309 |
| Horse | OR4N2F | 89% | 308 |
| Horse | OR4N2D | 87% | 306 |
| Horse | OR4N2 | 86% | 305 |
| Chimp | OR4N2 | 87% | 306 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | GD259804 |
| mRNA | DQ786223 |
Sequence information
| Nucleotide sequence |
ATGAAGATAGCAAACAACACAGTAGTGACAGAATTTATCCTCCTTGGTCTGACTCAGTCT CAAGATATTCAGCTCTTGGTCTTTGTGCTGATCTTAATTTTCTACCTTATCATCCTCCCT GGAAATTTTCTCATTATTTTCACCATAAGGTCAGACCCTGGGCTCACAGCCCCCCTCTAT TTATTTCTGGGCAACTTGGCCTTCCTGGATGCATCCTACTCCTTCATTGTGGCTCCCAGG ATGTTGGTGGACTTCCTCTCTGAGAAAAAGGTAATCTCCTACAGAGGCTGCATCACTCAG CTCTTTTTCTTGCACTTCCTTGGAGGAGGGGAGGGATTACTCCTTGTTGTGATGGCCTTT GACCGCTACATCGCCATCTGCCGGCCTCTGCACTGTTCAACTGTCATGAACCCTAGAGCC TGCTATGCAATGATGTTGGCTCTGTGGCTTGGGGGTTTTGTCCACTCCATTATCCAGGTG GTCCTCATCCTCCGCTTGCCTTTTTGTGGCCCAAACCAGCTGGACAACTTCTTCTGTGAT GTCCGACAGGTCATCAAGCTGGCTTGCACCGACATGTTTGTGGTGGAGCTTCTAATGGTC TTCAACAGTGGCCTGATGACACTCCTGTGCTTTCTGGGGCTTCTGGCTTCCTATGCAGTC ATCCTCTGCCATGTTCGTAGGGCAGCTTCTGAAGGGAAGAACAAGGCCATGTCCACGTGC ACCACTCGTGTCATTATTATACTTCTTATGTTTGGACCTGCTATCTTCATCTACATGTGC CCTTTCAGGGCCTTACCAGCTGACAAGATGGTTTCTCTCTTTCACACAGTGATCTTTCCA TTGATGAATCCTATGATTTATACCCTTCGCAACCAGGAAGTGAAAACTTCCATGAAGAGG TTATTGAGTCGACATGTAGTCTGTCAAGTGGATTTTATAATAAGAAAC |
| Conceptual translation |
MKIANNTVVTEFILLGLTQSQDIQLLVFVLILIFYLIILPGNFLIIFTIRSDPGLTAPLY LFLGNLAFLDASYSFIVAPRMLVDFLSEKKVISYRGCITQLFFLHFLGGGEGLLLVVMAF DRYIAICRPLHCSTVMNPRACYAMMLALWLGGFVHSIIQVVLILRLPFCGPNQLDNFFCD VRQVIKLACTDMFVVELLMVFNSGLMTLLCFLGLLASYAVILCHVRRAASEGKNKAMSTC TTRVIIILLMFGPAIFIYMCPFRALPADKMVSLFHTVIFPLMNPMIYTLRNQEVKTSMKR LLSRHVVCQVDFIIRN Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 15 | 100 | -100 | SYN | G/A | T/T | 1000GP (YRI) |
| 15 | 22,095,238 | 22,095,238 | SYN | G/A | T/T | 1000GP (CEU, CHBJPT) |
| 15 | 22,095,298 | 22,095,298 | NS | G/A | M/I | 1000GP (CEU) |
| 15 | 22,382,655 | 22,382,655 | NS | A/C | L/F | rs535034 (DbSNP) |
| 15 | 22,382,704 | 22,382,704 | NS | C/G | P/A | rs62006708 (DbSNP) |
| 15 | 22,382,728 | 22,382,728 | NS | C/T | L/F | rs2808136 (DbSNP) |
| 15 | 22,382,739 | 22,382,739 | SYN | G/A | K/K | rs2671839 (DbSNP) |
| 15 | 22,382,821 | 22,382,821 | NS | C/G | L/V | rs12438969 (DbSNP) |
| 15 | 22,382,828 | 22,382,828 | NS | A/C | D/A | rs62006709 (DbSNP) |
| 15 | 22,382,897 | 22,382,897 | NS | A/G | Y/C | rs62006710 (DbSNP) |
| 15 | 22,383,064 | 22,383,064 | NS | A/C | I/L | rs12441468 (DbSNP) |
| 15 | 22,383,066 | 22,383,066 | SYN | A/G | L/L | rs559754 (DbSNP) |
| 15 | 22,383,066 | 22,383,068 | mnp | CAT/TAG | rs67576397 (DbSNP) | |
| 15 | 22,383,149 | 22,383,149 | NS | A/G | H/R | rs74002754 (DbSNP) |
| 15 | 22,383,188 | 22,383,188 | NS | T/C | M/T | rs475947 (DbSNP) |
| 15 | 22,383,189 | 22,383,189 | SYN | A/G | T/T | rs1820851 (DbSNP) |
| 15 | 22,383,292 | 22,383,292 | NS | T/C | F/L | rs3817271 (DbSNP) |
| 15 | 22,383,405 | 22,383,405 | SYN | C/T | D/D | rs74002755 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 15 | 20,003,725 | 23,814,757 | CopyNumber | Variation_3951 (DGV) |
| 15 | 20,143,651 | 23,690,892 | CopyNumber | Variation_3070 (DGV) |
| 15 | 20,161,372 | 22,449,059 | CopyNumber | Variation_49468 (DGV), Variation_49469 (DGV) |
| 15 | 20,161,372 | 22,755,185 | CopyNumber | Variation_49470 (DGV) |
| 15 | 20,161,372 | 23,226,254 | CopyNumber | Variation_49471 (DGV) |
| 15 | 20,167,086 | 22,588,036 | CopyNumber | Variation_8779 (DGV) |
| 15 | 20,167,086 | 22,862,959 | CopyNumber | Variation_34576 (DGV) |
| 15 | 20,167,086 | 22,869,764 | CopyNumber | Variation_8781 (DGV) |
| 15 | 20,167,086 | 23,222,284 | CopyNumber | Variation_9251 (DGV), Variation_34504 (DGV) |
| 15 | 20,167,086 | 23,854,707 | CopyNumber | Variation_8784 (DGV) |
| 15 | 20,167,089 | 22,588,036 | CopyNumber | Variation_9250 (DGV) |
| 15 | 20,167,089 | 22,869,763 | CopyNumber | Variation_34665 (DGV) |
| 15 | 20,167,089 | 23,222,284 | CopyNumber | Variation_34608 (DGV) |
| 15 | 20,171,787 | 22,646,418 | CopyNumber | Variation_31980 (DGV) |
| 15 | 20,198,198 | 22,591,284 | CopyNumber | Variation_30670 (DGV) |
| 15 | 20,266,957 | 22,674,466 | CopyNumber | Variation_0318 (DGV) |
| 15 | 20,397,403 | 22,698,551 | CopyNumber | Variation_7046 (DGV) |
| 15 | 20,422,586 | 22,588,019 | CopyNumber | Variation_34663 (DGV) |
| 15 | 20,610,110 | 22,575,858 | Inversion | Variation_0443 (DGV) |
| 15 | 20,625,544 | 22,559,977 | Inversion | Variation_0444 (DGV) |
| 15 | 20,851,594 | 22,588,036 | CopyNumber | Variation_34545 (DGV) |
| 15 | 20,852,150 | 23,222,284 | CopyNumber | Variation_8785 (DGV) |
| 15 | 20,879,638 | 22,777,875 | CopyNumber | Variation_9254 (DGV) |
| 15 | 20,935,075 | 22,777,875 | CopyNumber | Variation_8783 (DGV) |
| 15 | 21,012,524 | 23,222,284 | CopyNumber | Variation_9256 (DGV) |
| 15 | 21,054,356 | 22,453,425 | CopyNumber | Variation_76814 (DGV), Variation_87462 (DGV) |
| 15 | 21,072,035 | 22,588,019 | CopyNumber | Variation_34607 (DGV) |
| 15 | 21,097,124 | 22,449,059 | CopyNumber | Variation_9742 (DGV) |
| 15 | 21,200,251 | 22,588,036 | CopyNumber | Variation_8786 (DGV) |
| 15 | 21,276,422 | 22,453,425 | CopyNumber | Variation_87468 (DGV) |
| 15 | 21,362,809 | 22,453,425 | CopyNumber | Variation_76815 (DGV) |
| 15 | 22,262,145 | 22,453,425 | CopyNumber | Variation_76813 (DGV) |
| 15 | 22,262,185 | 22,596,129 | CopyNumber | Variation_72162 (DGV) |
| 15 | 22,265,649 | 22,591,752 | CopyNumber | Variation_37535 (DGV), Variation_37626 (DGV) |
| 15 | 22,286,537 | 22,453,425 | CopyNumber | Variation_87461 (DGV) |
| 15 | 22,287,131 | 22,399,235 | CopyNumber | Variation_59598 (DGV) |
| 15 | 22,302,006 | 22,588,022 | CopyNumber | Variation_38952 (DGV) |
| 15 | 22,304,940 | 22,427,590 | CopyNumber | Variation_72152 (DGV) |
| 15 | 22,307,069 | 22,474,088 | CopyNumber | Variation_2182 (DGV) |
| 15 | 22,320,036 | 22,588,036 | CopyNumber | Variation_8782 (DGV), Variation_34557 (DGV) |
| 15 | 22,320,057 | 22,588,019 | CopyNumber | Variation_9249 (DGV), Variation_34643 (DGV) |
| 15 | 22,320,057 | 22,777,875 | CopyNumber | Variation_9252 (DGV) |
| 15 | 22,348,218 | 22,544,992 | CopyNumber | Variation_4873 (DGV) |
| 15 | 22,351,239 | 22,449,059 | CopyNumber | Variation_9741 (DGV), Variation_10464 (DGV) |
| 15 | 22,370,110 | 22,383,638 | CopyNumber | Variation_72155 (DGV) |
| 15 | 22,372,655 | 22,384,026 | CopyNumber | Variation_23197 (DGV) |
| 15 | 22,372,924 | 22,453,425 | CopyNumber | Variation_87464 (DGV) |
| 15 | 22,382,373 | 22,385,420 | Deletion, CopyNumber | #302 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| A78P | L86F | V117L | A119D | R128W | C132Y | Y142C | L198I | R226H | T239M | M259I | F274L | R304Q | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | A | L | V | A | R | C | Y | L | R | T | M | F | R | 53.23 | 1.000 |
| 2 | P | L | V | A | R | C | C | L | R | T | M | F | R | 14.82 | 1.000 |
| 3 | A | F | L | D | R | C | Y | I | R | T | M | F | R | 9.06 | 1.000 |
| 4 | A | F | L | A | R | C | Y | I | R | T | M | F | R | 5.22 | 1.000 |
| 5 | A | F | L | D | R | C | Y | L | R | T | M | F | R | 3.07 | 1.000 |
| 6 | A | L | V | A | R | C | C | L | R | T | M | F | R | 1.46 | 1.000 |
| 7 | A | L | V | A | R | C | Y | L | R | T | M | L | R | 1.46 | 1.000 |
| 8 | A | F | L | A | R | C | Y | L | R | T | M | F | R | 1.31 | 1.000 |
| 9 | A | L | L | A | R | C | Y | I | R | T | M | F | R | 1.08 | 1.000 |
| 10 | A | L | L | D | R | C | Y | L | R | T | M | F | R | 0.92 | 1.000 |
| 11 | A | F | V | A | R | C | Y | L | R | T | M | F | R | 0.84 | 1.000 |
| 12 | A | L | V | A | W | Y | Y | L | R | T | M | F | R | 0.84 | 0.937 |
| 13 | A | L | V | A | R | C | Y | I | R | T | M | F | R | 0.77 | 1.000 |
| 14 | P | L | V | A | R | C | Y | L | R | T | M | F | R | 0.69 | 1.000 |
| 15 | A | F | V | A | R | C | Y | I | R | T | M | F | R | 0.69 | 1.000 |
| 16 | A | L | V | A | W | Y | Y | L | H | T | M | F | Q | 0.61 | 0.937 |
| 17 | A | L | V | A | R | C | Y | L | R | T | I | F | R | 0.61 | 1.000 |
| 18 | A | L | L | D | R | C | Y | I | R | T | M | F | R | 0.54 | 1.000 |
| 19 | A | L | L | A | R | C | Y | L | R | T | M | F | R | 0.31 | 1.000 |
| 20 | P | L | V | A | R | C | C | L | R | T | I | F | R | 0.15 | 1.000 |
| 21 | A | L | L | A | W | Y | Y | L | R | T | M | F | R | 0.15 | 0.937 |
| 22 | A | L | V | A | W | Y | Y | L | R | M | M | F | R | 0.15 | 0.982 |
| 23 | A | F | V | A | W | Y | Y | L | R | T | M | F | R | 0.15 | 0.937 |
| 24 | A | L | V | A | R | C | Y | L | H | T | M | F | R | 0.15 | 1.000 |
| 25 | A | F | L | D | R | C | C | L | R | T | M | F | R | 0.15 | 1.000 |
| 26 | A | L | V | D | R | C | Y | L | R | T | M | F | R | 0.15 | 1.000 |
| 27 | P | L | V | A | R | C | C | L | R | T | M | L | R | 0.08 | 1.000 |
| 28 | P | L | L | D | R | C | C | L | R | T | M | F | R | 0.08 | 1.000 |
| 29 | A | F | V | A | R | C | Y | L | H | T | M | F | Q | 0.08 | 1.000 |
| 30 | A | F | L | D | W | Y | Y | L | H | T | M | F | Q | 0.08 | 0.957 |
| 31 | A | F | V | A | R | C | Y | L | R | M | M | F | R | 0.08 | 1.000 |
| 32 | A | F | V | A | W | Y | Y | I | R | T | M | F | R | 0.08 | 0.937 |
| 33 | A | F | V | A | R | C | Y | L | H | T | M | F | R | 0.08 | 1.000 |
| 34 | A | F | V | A | W | Y | Y | L | H | T | M | F | Q | 0.08 | 0.937 |
| 35 | A | L | V | A | R | C | C | L | R | T | M | L | R | 0.08 | 1.000 |
| 36 | A | F | L | A | R | C | Y | L | R | M | M | F | R | 0.08 | 1.000 |
| 37 | P | F | L | A | R | C | Y | I | R | T | M | F | R | 0.08 | 1.000 |
| 38 | A | F | V | A | W | Y | Y | L | R | M | M | F | R | 0.08 | 0.982 |
| 39 | A | F | L | A | R | C | C | L | R | T | M | F | R | 0.08 | 1.000 |
| 40 | A | L | V | A | W | Y | Y | L | R | T | M | F | Q | 0.08 | 0.937 |
| 41 | A | F | L | D | R | C | Y | I | H | T | M | F | R | 0.08 | 1.000 |
| 42 | A | F | L | D | R | C | Y | I | R | T | M | L | R | 0.08 | 1.000 |
| 43 | P | L | V | A | W | Y | C | L | R | T | M | F | R | 0.08 | 0.937 |
| 44 | P | L | V | A | W | Y | C | L | H | T | M | F | Q | 0.08 | 0.937 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4Q1PandOR4M2andOR4N4.aApr07 | exon_5UTR | chr15 | 22,015,234 | 22,015,331 | + | |
| exon_5UTR | chr15 | 22,030,926 | 22,031,020 | + | ||
| exon_5UTR | chr15 | 22,044,437 | 22,044,825 | + | ||
| exon_5UTR | chr15 | 22,058,721 | 22,058,816 | + | ||
| exon_5UTR | chr15 | 22,059,321 | 22,059,409 | + | ||
| exon_5UTR | chr15 | 22,059,632 | 22,059,835 | + | ||
| main_exon | 5UTR | chr15 | 22,094,513 | 22,094,522 | + | |
| CDS | chr15 | 22,094,522 | 22,095,469 | + | ||
| 3UTR | chr15 | 22,095,469 | 22,095,864 | + | ||