OR4Q3 Olfactory Receptor
| Gene Symbol | OR4Q31 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | Q |
| Pseudogene | No |
| CORP pseudogene probability score | 0.17 (functional) |
| Aliases | OR14-3, HsOR14.1.3, ORL3814 |
| External Ids | HGNC: 15426 GeneBank: AB065609, AF179768, BK004488, NM_172194 ORDB: ORL3814 |
| Build #39 labels | OR4Q3, OR4Q4 |
| Chromosomal location | 14:19,747,428-19,748,366 (+) |
| Cluster | 14@20b |
| Synteny | CLIC#32 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4Q1P | 93.59% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4Q3B | 86% | 305 |
| Mouse | Or4q3 | 82% | 304 |
| Rat | Or4q3-ps | 79% | 304 |
| Cow | OR4K14 | 58% | 305 |
| Orang | OR4Q3P | 96% | 311 |
| Orang | OR4Q3BP | 95% | 309 |
| Orang | OR4Q3CP | 94% | 283 |
| Horse | OR4Q12P | 80% | 304 |
| Chimp | OR4Q2 | 59% | 305 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | AB463966 |
| GNF Atlas2 | gnf1h02183_at |
Sequence information
| Nucleotide sequence |
ATGAAAAAAGAACAAGATTCTAATGTGACAGAATTTGTTCTTCTGGGCCTATCATCTTCT TGGGAGCTGCAGCTATTTCTCTTCTTACTATTTTTGTTTTTTTACATTGCTATTGTCCTG GGAAACCTCTTGATAGTGGTAACAGTGCAAGCCCATGCTCACCTGCTCCAATCTCCTATG TATTATTTTTTAGGTCATCTCTCTTTCATTGACCTATGCCTGAGCTGTGTTACTGTGCCA AAGATGTTAGGGGATTTCCTACAGCAGGGCAAGAGCATCTCTTTTTCAGGATGCCTGGCC CAGATCTACTTCCTCCACTTTCTAGGAGCCAGTGAGATGTTTTTGCTGACAGTCATGGCC TATGACAGGTATGTTGCCATCTGTAACCCTTTGCGCTACCTTACAGTCATGAACCCCCAG CTATGCCTTTGGTTGGTTCTTGCCTGCTGGTGTGGGGGTTTTATCCACTCTATCATGCAG GTCATACTAGTCATCCAGCTGCCTTTCTGTGGGCCCAATGAACTGGACAACTTCTACTGT GATGTCCCACAAGTCATCAAGCTGGCCTGCATGGACACCTATGTGGTAGAGGTGCTGGTG ATAGCCAACAGTGGTCTGCTGTCTCTTGTCTGCTTCTTGGTCTTACTATTCTCTTATGCT ATCATCCTGATCACCCTGAGAACACACTTCTGCCAGGGCCAGAACAAGGTCTTCTCTACC TGTGCTTCTCACCTGACAGTGGTCAGCCTGATCTTCGTGCCATGCGTATTCATCTATTTG AGGCCTTTCTGCAGCTTCTCTGTGGATAAGATATTCTCCTTGTTTTACACAGTGATTACA CCTATGTTGAACCCCCTCATCTACACACTCAGAAATACTGATATGAAGACAGCTATGAAG AAGCTGAGGATAAAACCATGTGGCATTCCATTGCCTTGT |
| Conceptual translation |
MKKEQDSNVTEFVLLGLSSSWELQLFLFLLFLFFYIAIVLGNLLIVVTVQAHAHLLQSPM YYFLGHLSFIDLCLSCVTVPKMLGDFLQQGKSISFSGCLAQIYFLHFLGASEMFLLTVMA YDRYVAICNPLRYLTVMNPQLCLWLVLACWCGGFIHSIMQVILVIQLPFCGPNELDNFYC DVPQVIKLACMDTYVVEVLVIANSGLLSLVCFLVLLFSYAIILITLRTHFCQGQNKVFST CASHLTVVSLIFVPCVFIYLRPFCSFSVDKIFSLFYTVITPMLNPLIYTLRNTDMKTAMK KLRIKPCGIPLPC Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 14 | 20,215,674 | 20,215,674 | NS | A/C | I/L | rs4494468 (DbSNP) |
| 14 | 20,215,989 | 20,215,989 | NS | A/G | T/A | rs17210864 (DbSNP) |
| 14 | 20,215,779 | 20,215,779 | NS | A/G | S/G | rs4412904 (DbSNP) |
| 14 | 20,216,298 | 20,216,298 | NS | C/T | L/F | rs12896533 (DbSNP) |
| 14 | 20,216,404 | 20,216,404 | NS | C/T | S/F | rs45516108 (DbSNP) |
| 14 | 20,215,637 | 20,215,637 | SYN | A/G | L/L | rs28652816 (DbSNP) |
| 14 | 19,747,830 | 19,747,830 | NS | A/G | T/A | 1000GP (CEU, CHBJPT) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 14 | 20,197,616 | 20,399,048 | CopyNumber | Variation_0316 (DGV) |
| 14 | 20,203,125 | 20,539,108 | CopyNumber | Variation_3036 (DGV) |
| 14 | 19,662,531 | 20,556,187 | CopyNumber | Variation_3929 (DGV) |
| 14 | 20,080,166 | 20,271,356 | CopyNumber | Variation_4824 (DGV) |
| 14 | 20,095,109 | 20,231,601 | CopyNumber | Variation_4825 (DGV) |
| 14 | 19,117,183 | 20,424,605 | CopyNumber | Variation_7028 (DGV) |
| 14 | 20,203,125 | 20,483,660 | CopyNumber | Variation_8762 (DGV) |
| 14 | 20,203,125 | 20,626,160 | CopyNumber | Variation_8763 (DGV) |
| 14 | 20,203,125 | 20,716,841 | CopyNumber | Variation_8765 (DGV) |
| 14 | 20,203,125 | 20,433,044 | CopyNumber | Variation_9234 (DGV) |
| 14 | 20,177,234 | 20,424,604 | CopyNumber | Variation_30648 (DGV) |
| 14 | 19,360,239 | 20,424,604 | CopyNumber | Variation_31953 (DGV) |
| 14 | 20,203,125 | 20,525,833 | CopyNumber | Variation_34547 (DGV) |
| 14 | 20,203,125 | 20,456,434 | CopyNumber | Variation_34575 (DGV) |
| 14 | 20,203,125 | 20,655,466 | CopyNumber | Variation_34656 (DGV) |
| 14 | 20,203,125 | 20,550,348 | CopyNumber | Variation_34660 (DGV) |
| 14 | 20,203,125 | 20,455,307 | CopyNumber | Variation_34664 (DGV) |
| 14 | 19,670,757 | 20,331,117 | CopyNumber | Variation_37621 (DGV) |
| 14 | 20,200,183 | 20,423,372 | CopyNumber | Variation_38951 (DGV) |
| 14 | 19,349,922 | 20,424,856 | CopyNumber | Variation_58655 (DGV) |
| 14 | 20,177,210 | 20,424,753 | CopyNumber | Variation_66584 (DGV) |
| 14 | 20,194,500 | 20,255,301 | CopyNumber | Variation_71832 (DGV) |
| 14 | 19,781,170 | 20,424,776 | CopyNumber | Variation_71833 (DGV) |
| 14 | 20,198,061 | 20,307,453 | CopyNumber | Variation_71859 (DGV) |
| 14 | 20,152,622 | 20,419,574 | CopyNumber | Variation_76554 (DGV), Variation_87112 (DGV) |
| 14 | 20,185,336 | 20,310,638 | CopyNumber | Variation_76557 (DGV) |
| 14 | 20,179,862 | 20,261,582 | CopyNumber | Variation_87116 (DGV) |
| 14 | 20,196,206 | 20,245,238 | CopyNumber | Variation_87117 (DGV) |
| 14 | 20,201,654 | 20,343,302 | CopyNumber | Variation_87118 (DGV) |
| CopyNumber | 118 (Hasin) | |||
| 14 | 20,215,487 | 20,218,525 | CopyNumber | #159 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| T135A | Q184H | F238L | V256I | Y259C | % Freq | CORP | |
|---|---|---|---|---|---|---|---|
| 1 | T | Q | L | V | Y | 62.44 | 0.342 |
| 2 | T | Q | F | V | Y | 30.11 | 0.342 |
| 3 | A | Q | L | V | Y | 6.30 | 0.342 |
| 4 | A | Q | F | V | Y | 0.84 | 0.342 |
| 5 | T | Q | L | I | Y | 0.15 | 0.342 |
| 6 | T | Q | F | V | C | 0.08 | 0.342 |
| 7 | T | H | F | V | Y | 0.08 | 0.342 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4Q3.aApr07-unspliced | main_exon | CDS | chr14 | 19,747,428 | 19,748,366 | + |
| 3UTR | chr14 | 19,748,366 | 19,748,369 | + | ||