OR4S1 Olfactory Receptor
| Gene Symbol | OR4S11 (View this gene in GeneCards) |
| Family | 4 |
| Subfamily | S |
| Pseudogene | No |
| CORP pseudogene probability score | 0.08 (functional) |
| Aliases | OR11-100, HsOR11.8.5, ORL3737 |
| External Ids | HGNC: 14705 GeneBank: AB065908, BK004348, NM_001004725 ORDB: ORL3737 |
| Build #39 labels | OR4S1 |
| Chromosomal location | 11:48,306,223-48,307,149 (+) |
| Cluster | 11@48 |
| Synteny | CLIC#26 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR4C10P | 55.02% | 309 |
| OR4C3 | 55.67% | 300 |
| OR4S2 | 60.47% | 296 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR4S1B | 86% | 309 |
| Mouse | Or4s2 | 60% | 305 |
| Rat | Or4s2 | 59% | 305 |
| Cow | OR4X2 | 57% | 309 |
| Orang | OR4S1P | 93% | 309 |
| Horse | OR4S1P | 86% | 297 |
| Chimp | OR4S2 | 60% | 300 |
Expression evidences
| Source | Accession |
|---|---|
| GNF Atlas2 | gnf1h02091_at |
Sequence information
| Nucleotide sequence |
ATGGGTGCCAAGAACAATGTGACTGAGTTTGTTTTATTTGGCCTTTTTGAGAGCAGAGAG ATGCAGCATACATGCTTTGTGGTATTCTTCCTCTTTCATGTGCTCACTGTCCTGGGGAAC CTTCTGGTCATCATCACCATCAATGCTAGAAAGACCCTGAAGTCTCCCATGTATTTCTTC CTGAGCCAGTTGTCTTTTGCTGACATATGTTATCCATCCACTACCATACCCAAGATGATT GCTGACACTTTTGTGGAGCATAAGATCATCTCCTTCAATGGCTGCATGACCCAGCTCTTT TCTGCCCACTTCTTTGGTGGCACTGAGATCTTCCTCCTTACAGCCATGGCCTATGACCGC TATGTGGCCATCTGTAGGCCCCTGCACTACACAGCCATCATGGATTGCCGGAAGTGTGGC CTGCTAGCGGGGGCCTCCTGGTTAGCTGGCTTCCTGCATTCCATCCTGCAGACCCTCCTC ACGGTTCAGCTGCCTTTTTGTGGGCCCAATGAGATAGACAACTTCTTCTGTGATGTTCAT CCCCTGCTCAAGTTGGCCTGTGCAGACACCTACATGGTAGGTCTCATCGTGGTGGCCAAC AGCGGTATGATTTCTTTAGCATCCTTTTTTATCCTTATCATTTCCTATGTTATCATCTTA CTGAACCTAAGAAGCCAGTCATCTGAGGACCGGCGTAAGGCTGTCTCCACATGTGGCTCA CACGTAATCACTGTCCTTTTGGTTCTCATGCCCCCCATGTTCATGTACATTCGTCCCTCC ACCACCCTGGCTGCTGACAAACTTATCATCCTCTTTAACATTGTGATGCCACCTTTGCTG AACCCTTTGATCTATACACTAAGGAACAACGATGTGAAAAATGCCATGAGGAAGCTGTTT AGGGTCAAGAGGAGCTTAGGGGAGAAG |
| Conceptual translation |
MGAKNNVTEFVLFGLFESREMQHTCFVVFFLFHVLTVLGNLLVIITINARKTLKSPMYFF LSQLSFADICYPSTTIPKMIADTFVEHKIISFNGCMTQLFSAHFFGGTEIFLLTAMAYDR YVAICRPLHYTAIMDCRKCGLLAGASWLAGFLHSILQTLLTVQLPFCGPNEIDNFFCDVH PLLKLACADTYMVGLIVVANSGMISLASFFILIISYVIILLNLRSQSSEDRRKAVSTCGS HVITVLLVLMPPMFMYIRPSTTLAADKLIILFNIVMPPLLNPLIYTLRNNDVKNAMRKLF RVKRSLGEK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 48,327,947 | 48,327,947 | NS | A/G | Y/C | rs11601697 (DbSNP) |
| 11 | 48,328,184 | 48,328,184 | NS | A/G | Q/R | rs61749289 (DbSNP) |
| 11 | 48,328,639 | 48,328,639 | NS | A/G | N/D | rs61730866 (DbSNP) |
| 11 | 48,328,193 | 48,328,193 | NS | C/G | A/G | rs61749290 (DbSNP) |
| 11 | 48,328,121 | 48,328,121 | NS | C/T | T/M | rs35930119 (DbSNP) |
| 11 | 48,327,841 | 48,327,841 | NS | C/T | H/Y | rs61745904 (DbSNP) |
| 11 | 48,327,834 | 48,327,834 | NS | G/T | E/D | rs61745901 (DbSNP) |
| 11 | 48,328,644 | 48,328,644 | SYN | C/T | N/N | rs753095 (DbSNP) |
| 11 | 48,307,092 | 48,307,092 | SYN | C/T | N/N | 1000GP (CEU, CHBJPT) |
| 11 | 48,306,569 | 48,306,569 | NS | T/C | M/T | 1000GP (CEU) |
| 11 | 48,306,546 | 48,306,546 | SYN | T/C | T/T | 1000GP (CEU) |
| 11 | 100 | -100 | NS | G/T | V/L | 1000GP (YRI) |
| 11 | 100 | -100 | SYN | C/T | N/N | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 48,303,671 | 48,863,606 | CopyNumber | Variation_3848 (DGV) |
| 11 | 48,327,709 | 48,328,760 | CopyNumber | Variation_30549 (DGV) |
| 11 | 48,327,960 | 48,328,962 | CopyNumber | Variation_85759 (DGV) |
| 11 | 48,327,710 | 48,327,997 | InDel | Variation_11051 (DGV) |
| 11 | 48,327,528 | 48,328,240 | InDel | Variation_58520 (DGV) |
| 11 | 48,327,672 | 48,328,178 | InDel | Variation_65938 (DGV) |
| 11 | 48,328,162 | 48,328,262 | InDel | Variation_75635 (DGV) |
| 11 | 48,328,182 | 48,328,342 | InDel | Variation_75636 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| E20D | M116T | R137Q | N289D | % Freq | CORP | |
|---|---|---|---|---|---|---|
| 1 | E | M | R | N | 97.77 | 0.119 |
| 2 | E | T | R | N | 1.08 | 0.352 |
| 3 | E | M | R | D | 0.54 | 0.119 |
| 4 | D | M | R | N | 0.31 | 0.119 |
| 5 | E | M | Q | N | 0.31 | 0.119 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR4S1.aApr07-unspliced | main_exon | CDS | chr11 | 48,306,223 | 48,307,149 | + |
| 3UTR | chr11 | 48,307,149 | 48,307,152 | + | ||