OR51B2 Olfactory Receptor
| Gene Symbol | OR51B21 (View this gene in GeneCards) |
| Family | 51 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | AF149710, HsOR11.3.57, ORL481 |
| External Ids | HGNC: 14703 GeneBank: AF399503 ORDB: ORL481 |
| Build #39 labels | OR51B2, OR51B1P |
| Chromosomal location | 11:5,323,362-5,324,297 (-) |
| Cluster | 11@5 |
| Synteny | CLIC#23 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs7952293) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR51B4 | 66.01% | 306 |
| OR51B5 | 67.43% | 304 |
| OR51B6 | 69.97% | 303 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR51B18 | 79% | 309 |
| Mouse | Or51b17 | 76% | 306 |
| Rat | Or51b17 | 76% | 305 |
| Cow | OR51B19P | 60% | 297 |
| Orang | OR51B6 | 70% | 303 |
| Horse | OR51B6 | 72% | 306 |
| Chimp | OR51B6 | 69% | 303 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC117461 |
Sequence information
| Nucleotide sequence |
ATGTGGCCCAATATTACTGCAGCCCCTTTTTTGCTGACTGGCTTTCCAGGGCTGGAGGCA GCTCATCACTGGATCTCCATCCCCTTCTTTGCTGTTTATGTGTGCATCCTTCTGGGCAAT GGCATGCTCCTCTACCTCATCAAGCATGACCACAGTCTTCATGAGCCCATGTACTACTTC CTCACCATGCTGGCAGGCACAGACCTCATGGTGACATTGACCACGATGCCTACTGTAATG GGCATCCTATGGGTGAATCACAGGGAGATTAGCAGTGTGGGCTGCTTCCTACAGGCTTAC TTTATTCACTCCCTTTCTGTTGTGGAATCAGGTTCCCTCCTGGCAATGGCATATGATTGT TTCATTGCCATCCGCAATCCTTTGAGATATGCTTCCATTCTCACCAATACTAGAGTCATA GCGTTAGGAGTGGGAGTGTTTCTAAGGGGTTTTGTATCCATCCTGCCTGTAATTTTGCGT CTTTTTTCATTTTCATATTGCAAATCTCATGTTATCACACGTGCTTTCTGCCTCCACCAA GAAATCATGAGACTGGCTTGTGCTGACATAACTTTCAATAGACTTTACCCTGTAATTTTG ATCTCTTTAACAATCTTCCTAGACTGTCTGATCATCCTCTTCTCCTATATTCTAATTCTT AATACTGTCATAGGCATTGCTTCTGGTGAAGAGAGAGCCAAAGCCCTCAATACCTGTATC TCCCACATTAGTTGTGTTCTTATCTTCTATGTTACAGTGATGGGTTTGACATTCATTTAC AGATTTGGGAAGAATGTGCCAGAGGTTGTCCACATTATCATGAGTTACATCTACTTCCTC TTTCCTCCTTTAATGAACCCTGTCATCTACAGCATCAAAACCAAGCAAATACAATATGGC ATTATCCGCCTTTTATCTAAACATAGGTTTAGTAGT |
| Conceptual translation |
MWPNITAAPFLLTGFPGLEAAHHWISIPFFAVYVCILLGNGMLLYLIKHDHSLHEPMYYF LTMLAGTDLMVTLTTMPTVMGILWVNHREISSVGCFLQAYFIHSLSVVESGSLLAMAYDC FIAIRNPLRYASILTNTRVIALGVGVFLRGFVSILPVILRLFSFSYCKSHVITRAFCLHQ EIMRLACADITFNRLYPVILISLTIFLDCLIILFSYILILNTVIGIASGEERAKALNTCI SHISCVLIFYVTVMGLTFIYRFGKNVPEVVHIIMSYIYFLFPPLMNPVIYSIKTKQIQYG IIRLLSKHRFSS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 5,345,094 | 5,345,093 | Ins(1) | -/C | rs34329019 (DbSNP) | |
| 11 | 5,345,170 | 5,345,170 | NS | A/G | C/R | rs7952293 (DbSNP) |
| 11 | 5,345,128 | 5,345,128 | NS | A/G | F/L | rs10837814 (DbSNP) |
| 11 | 5,344,681 | 5,344,681 | NS | A/G | S/P | rs11036815 (DbSNP) |
| 11 | 5,344,902 | 5,344,902 | NS | C/G | C/S | rs7937237 (DbSNP) |
| 11 | 5,345,486 | 5,345,486 | SYN | A/G | G/G | rs4910750 (DbSNP) |
| 11 | 5,344,847 | 5,344,847 | SYN | A/G | A/A | rs10768793 (DbSNP) |
| 11 | 5,344,772 | 5,344,772 | SYN | C/T | T/T | rs10742622 (DbSNP) |
| 11 | 5,323,617 | 5,323,617 | SYN | A/G | A/A | 1000GP (CEU, CHBJPT) |
| 11 | 5,323,898 | 5,323,898 | NS | G/A | L/F | 1000GP (CEU, CHBJPT) |
| 11 | 5,324,256 | 5,324,256 | SYN | G/A | G/G | 1000GP (CEU, CHBJPT) |
| 11 | 5,323,940 | 5,323,940 | NS | A/G | C/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,323,362 | 5,323,362 | NS | A/C | S/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,323,672 | 5,323,672 | NS | C/G | C/S | 1000GP (CEU, CHBJPT) |
| 11 | 5,323,451 | 5,323,451 | NS | G/A | P/S | 1000GP (CEU, CHBJPT) |
| 11 | 5,323,542 | 5,323,542 | SYN | T/C | T/T | 1000GP (CEU, CHBJPT) |
| 11 | 5,323,738 | 5,323,738 | NS | C/A | C/F | 1000GP (CHBJPT) |
| 11 | 100 | -100 | NS | G/A | P/S | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | T/C | T/T | 1000GP (YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,343,554 | 5,344,613 | CopyNumber | Variation_58522 (DGV) |
| 11 | 5,342,592 | 5,345,627 | CopyNumber | #60 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| S312R | S291N | P283S | C209S | L134F | C120R | W2G | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | S | S | P | S | F | R | W | 30.88 | 0.315 |
| 2 | S | S | S | S | L | R | W | 27.11 | 0.379 |
| 3 | S | S | P | C | L | C | W | 25.73 | 0.853 |
| 4 | R | S | P | S | F | R | W | 11.37 | 0.315 |
| 5 | S | S | P | S | L | R | W | 3.99 | 0.245 |
| 6 | S | S | P | S | F | R | G | 0.54 | 0.315 |
| 7 | S | S | S | S | L | C | W | 0.15 | 0.916 |
| 8 | S | N | P | S | L | R | W | 0.15 | 0.245 |
| 9 | S | S | S | C | L | R | W | 0.08 | 0.379 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR51B2.aApr07-unspliced | main_exon | 3UTR | chr11 | 5,323,298 | 5,323,362 | - |
| CDS | chr11 | 5,323,362 | 5,324,297 | - | ||
| 5UTR | chr11 | 5,324,297 | 5,324,352 | - | ||